Inositol Powder

Post any data on Treatments and experimentation.
Moloch
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Inositol Powder

Unread post by Moloch »

PharmD on Fri Jan 28, 2011 3:12 pm

First of all, a big thank you to the creator of this forum. I applaud your efforts in sharing your experiments with others in hopes for finding a solution to PSSD.

I have found inositol to be an effective agent in treating my social anxiety disorder (SAD) (if only I had discovered it before Paxil damaged my body pale ). This stuff is amazing! I have been keeping a log for the past 6 days, and I am happy to report that I have had consistant relief from SAD on every single one of those days. Trials show a benefit by week 4 but I can definately say that I am getting immediate relief from this stuff. Inositol has also been found to treat depression and OCD with comparable efficacy to SSRIs with a MUCH better side effect profile, so keep this in mind if you suffer from PSSD, dropped the SSRIs, and are still looking for a viable alternative to treat your depression, OCD, anxiety etc. Dose is in the 6 gram - 18 gram range daily (can be in divided doses as well).

I thought I might contribute to this board as I am self experimenting with the effects of Inositol on my PSSD.

Method of Action: Most conventional psychotropics in use today act at receptors on the cell membrane. Inositol, which acts at the second-messenger intracellular level, is a truly novel psychotropic agent. Chronic inositol administration has been found to induce a significant increase in striatal dopamine2 receptor density (Bmax), but not affinity, with a slight increase in 5HT2 receptor density, but not affinity. The changes observed in striatal D1-D2 balance will result in marked changes in activity in the cortical-striatal-thalamic circuit - and in the modultation of thalamic activation of the cortex and striatum. Inositol's effect on mGlu-1 receptors may modulate dopaminergic function indirectly and resent with biochemical and behavioral consequences of DA hyperactivity. (It is possible that Inositol and Serotonin Reuptake Inhibitors (SSRIs) converge to a common final, perhaps genetic, destination. It is also possible that Inositol actives a cascade of events (as do other antidepressants), but at a later point or a different cascade that eventually interacts of converges with the events related to other antidepressant drugs.) Inositol is a key intermediate of the phosphatidyl-inositol (PI) cycle - a second messenger system used by several noradrenergic alpha, several types of serotonergic and cholinergic nerve receptors and is a rate-limiting step in the synthesis of PI - considered a saturated system. No changes in mono-aminergic systems follow acute or chronic Inositol administration. Inositol is responsible for the production of second messengers Inositol triphospahte3 (IP3) and DAG and regulation of phospholipase C. Inositol functions as cell growth factor by stimulating fat used to construct myelinated nerve materials. In animal models, chronic dietary inositol significantly elevates cellular Inositol levels in the cortex (36%) and hippocampus (27%) but not in the striatum or cerebellum. Regional differences in inositol uptake by the brain may shed light on the mechanism of action of lithium in different brain regions. Cerebellar granule cells in culture, which do not accumulate high levels of inositol, are also less susceptible to inositol-induced reversal of the biochemical effects of lithium. (Introcerebroventricular replenishment of lithium-induced depletion of inositol reverses lithium's effects on behavior.) Inositol also reverses desensitization of serotonin receptors.

(FYI my PSSD is manifests as genital numbness and premature ejaculation (<--Successfully treated with Tramadol, numerous times))

My Log: (Dose is 6 grams twice daily)
Jan 24-27/11: No significant effect on my PSSD
Jan 28/11: I feel able to get aroused much easier when thinking about erotica. (Before I could be watching porn and struggle to get a hard-on).
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Thu Feb 03, 2011 6:58 am

That's interesting. I wouldn't think that genital numbness and premature ejaculation would manifest together. Just goes to show how strange PSSD is.

I'll have to try inositol powder. I have SAD and OCD too. Finding treatments for them is actually a side goal of mine.

I get a small amount of relief from N-acetyl Cysteine. It's not much, but it's noticeable and it's a cheap supplement. It's at least as good as memantine and way cheaper. I'll definitely give the inositol powder a try. My OCD symptoms in particular are quite bothersome.
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Thu Feb 03, 2011 8:08 am

I ordered some. I should have it by Monday at the latest.
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

PharmD on Fri Feb 04, 2011 1:59 am

Update:
Increased dose to 18 grams at bedtime on Feb 1/2011 (Solely due to convienience of once daily dosing)
Jan 29-Feb 3/2011: I am still finding that it helps with arousal; it takes much less physical stimulation/erotic images to get an erection. Premature ejaculation is unfortunately unchanged. Side effects are just like they said it would be: gas and diarrhea (although yesterday and today wasn't bad at all).

Sonny wrote:
That's interesting. I wouldn't think that genital numbness and premature ejaculation would manifest together. Just goes to show how strange PSSD is.


Ya, I wouldn't have thought it myself, but it's the reality unfortunately.

Sonny wrote:
.

I'll have to try inositol powder. I have SAD and OCD too. Finding treatments for them is actually a side goal of mine.

I get a small amount of relief from N-acetyl Cysteine. It's not much, but it's noticeable and it's a cheap supplement. It's at least as good as memantine and way cheaper. I'll definitely give the inositol powder a try. My OCD symptoms in particular are quite bothersome.



Great! Let us all know how it works for you!

Here is the study for reference:

Am J Psychiatry. 1996 Sep;153(9):1219-21.
Inositol treatment of obsessive-compulsive disorder.
Fux M, Levine J, Aviv A, Belmaker RH.
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
OBJECTIVE: Earlier studies reported that inositol, a simple polyol second messenger precursor, was effective in controlled trials for patients with depression and panic. In this study its effectiveness in obsessive-compulsive disorder was investigated. METHOD: Thirteen patients with obsessive-compulsive disorder completed a double-blind, controlled crossover trial of 18 g/day of inositol or placebo for 6 weeks each. RESULTS: The subjects had significantly lower scores on the Yale-Brown Obsessive Compulsive Scale when taking inositol than when taking placebo. CONCLUSIONS: The authors conclude that inositol is effective in depression, panic, and obsessive-compulsive disorder, a spectrum of disorders responsive to selective serotonin reuptake inhibitors.

What I've been doing is dissolving the powder in a water bottle, adding some Crystal Light and chugging it down (the powder itself has a sweet taste, but its much more palatable with Crystal Light). Side effects like I said are diarrhea and gas, but they seem to get better with continued use (I actually didn't have any of either today). Apparently caffeine consumption lowers inositol levels in the body.

Here is a good reference about inositol use in OCD http://www.ocdrecoverycenters.com/about ... sitol.html

Good luck!
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Fri Feb 04, 2011 8:34 am

Crystal light sounds like a good idea. I drink some stuff with caffeine, so that may mean taking a higher dose. I hope it doesn't aggravate my ADD. It did to some people but not others. It was mostly the type 1 (hyperactive) kind though. I did see one with the spacey kind that said she had a problem. That's the type I mainly have. We'll see how it goes. I'll start with a low dose and work my way up.
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

PharmD on Mon Feb 07, 2011 4:02 am

Update:
Feb 4-5/2011: Erections unchanged from last time, premature ejaculation unchanged.
Feb 6/2011: I accidentaly bought an Inositol Powder bottle with another supplement called Choline added to it. It is the same color bottle and I didn't even notice it until I got home. Anyway, I got home and took my regular dose in the evening. An hour later I can say that my erections have been phenomenal. I can get it up within seconds of physical or visual stimulation, just like the old days. After doing a bit of reading, choline is a precursor to acetylcholine which is apparently a key player in male erections:


http://ajpheart.physiology.org/content/ ... 8.abstract
Cholinergic neurotransmission in human corpus cavernosum.
Department of Urology, Boston University Medical Center, Massachusetts02118.
Abstract
Physiological and histochemical evidence indicates that cholinergic nerves may participate in mediating penile erection. Acetylcholine synthesis and release was studied in isolated human corporal tissue. Human corpus cavernosum incubated with [3H )choline accumulated [3H]choline and synthesized [3H]acetylcholine in a concentration-dependent manner. [3H]Acetylcholine accumulation by the tissue was inhibited by hemicholinium-3, a specific antagonist of the high-affinity choline transport in cholinergic nerves. Transmural electrical field stimulation caused release of [3H]acetylcholine which was significantly diminished by inhibiting neurotransmission with calcium-free physiological salt solution or tetrodotoxin. These observations provide biochemical and physiological evidence for the existence of cholinergic innervation in human corpus cavernosum.

Not only that; I felt really relaxed and comfortable when I went out with some buddies from work for dinner. With my social anxiety disorder, I would always sit there and feel like people are looking at me and judging me, but I amazingly felt no anxiety this time around. This is a feeling that I have never felt before. I know this could all be a placebo effect. I'm really tempted to continue my experiment using the inositol/choline combo, but I won't, for the sake of evaluating inositol by itself. For reference, the dose of choline that I took was 1500 mg.
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Wed Feb 09, 2011 8:27 am

I got the inositol power yesterday. I took 3 grams right before lunch. That made me a little drowsy, so I waited until bedtime and took another 5 grams. Tonight I am going to take 10 grams before bed. I think the convenience of a single dose is helpful. I also think I won't have to worry about drowsiness or a possible worsening of my ADD symptoms. All that will happen while I am asleep. With a big dose, I should be able to get the benefits without much in the way of side effects. No gas or anything like that. I have built up a tolerance to sugar free candy, so I may be immune to that side effect.
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Fri Feb 11, 2011 11:06 am

I continued with 10 grams. No effect on PSSD, small improvement in OCD and anxiety. No sides, I'm not drowsy, my ADD hasn't worsened and I don't have any digestive issues. So I just took 15 grams. I'll stick with that for a while unless I have problems with side effects.
Moloch
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Sat Feb 12, 2011 6:43 am

My ADD was VERY bad today. I had a lot of problems. I might have to stop taking this stuff. I haven't decided what I am going to do tonight yet. I could take 15 again, or go back to 10, or something in between the 2. Or I might not take it anymore. I couldn't hardly think at work. I don't know if I want to risk being in that situation tomorrow.
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Re: Experiment: Inositol Powder - PharmD OP

Unread post by Moloch »

Sonny on Sat Feb 12, 2011 11:16 am

I have to make a correction to Thursday. My wife did notice me having problems with being more spacey and distracted. I hadn't realized until we talked about it, but she is right. She pointed out some things I had forgotten about. Then of course with today being a catastrophe, and having little improvement in symptoms, I have decided to stop taking this. It did say it was contraindicated with ADD. So I knew this might be a problem. My last dose was over 24 hours ago. I will report on how I feel in the days after coming off of it. Then I will be back to looking for something else to try.

If anyone wants most of a 16 ounce container of this. http://www.amazon.com/gp/product/B000GF ... cx_subs_dp
I'll ship you what I have left (more than 400 grams), for $20, including shipping.
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