Sleep deprivation and PSSD Symptoms - az89 OP

[Ghost]

Post az89 on Fri May 09, 2014 5:12 pm

I've posted about it before, sleep deprivation >95% of time completely cures all of my symptoms (I's 9:11am right now, havn't slept and i can experience again), and also makes me feel how i used too before anti depressants (I only realise how bad my normal state of lack of excitement anhedonia is while in this sleep deprived state). Look into what happens to the receptors during sleep deprivation and you can find the mechanism for why we are the way we are now. Which then means you can target it with specific agonists/antagonists.

forgive me for the horrible punctuation and coherence but i really cbf reading thru it as my concentration is severely lacking right now.


nvm okiy gaiz it's really simple, i turn into geniouz mode with no sleeperinos

5ht (serotonin levels) is increased in the brain stem (Dorsal raphe nuclei) from sleep deprivation. This is where the 5ht1a autoreceptors are. Binding/Activating these particular receptors inhibits 5ht release in the other parts of the brain (WE WANT THIS). SSRI's also increase 5ht levels in the brain stem dramatically, so high that they eventually desensitise our 5ht1a autoreceptors... (This is what is considered the "therapeutic benefit" and why there is some weeks delay before it happens when you first start taking them, AKA this fucking HELL we are IN!!!!). For some reason our 5ht1a autoreceptors are permanently desensitized/down regulated through an unknown mechanism, after all this is what SSRI's target, and i have no idea why because there is a dramatic increase in happyness and emotion as soon as the complete opposite occurs!!! - Fuck their retarded studies!!! I think this receptor determines whether or not we are happy OR sad, because i can basically feel both now, depends what is bothering me... IT JUST MEANS YOUR NORMAL. For depressed people with horrible things going on in their lives, it makes sense to drain out this receptor, and make it non responsive, they basically become numb to the pain. I was never depressed before SSRI's so i don't care if this receptor returns to normal function, it means i'll be normal again. Perhaps this is why they target this receptor desensitization, BUT I'D LIKE TO POINT OUT TO THE STUDIES THAT being numb and forgetting about your pain IS NOT THE SAME THING as not being depressed.

Points to consider:
-If SSRI's can increase 5ht in the brain stem, would a realllly low dosage of them be able to help??? Remember high serotonin levels in the brain are bad - but in the brain stem it is good. 5ht1a autoreceptor activation inhibits serotonin release in most of the brain! - Probably won't work because they will still activate all the serotonin in the brain
-Can anyone successfully obtain a 5ht1a autoreceptor agonist??
-If the outcome of 5ht1a autoreceptor activation means serotonin inhibition in most of the brain, then a heavily carb restricted diet can help as it basically makes it so you have really low serotonin levels.
-Carbs bloat the shit out of me, i feel more normal without them... ever since SSRI's i bloat and have a lot of gas, there are a lot of serotonin receptors in the gut, would make sense that i have high serotonin levels

Disclaimer : Could be wrong Smile

Only 5ht1a autoreceptor agonist i could find was Idazoxan - http://www.sciencedirect.com/science/ar ... 4096131323
Also that drug has been studied for desire/sexual dysfunction and found to be of help at least in rat studies. http://onlinelibrary.wiley.com/doi/10.1 ... 5367.x/pdf


Sources: http://www.readcube.com/articles/10.101 ... 97)00025-0
and me.

[gianno121]

Everytime i dont sleep more than 3 or 4 hours my libido seems to get a way higher than it used to be on normal PSSD. Erecrtions are also easier to get and harder than usual. I masurbate like 3 or 4 times a day when im sleepless.
Btw there are no drugs or medicals in this relationship.

Does anybody have similar experiences? I remember time ago someone told me that when you are sleepless your dopamin system works different or something.

[kamikaz3]

Yes, exactly the same here

[gianno121]

So could less sleep Maybe be a treatment? Maybe i should try it for some days.

[Marksanchez397]

Everytime i dont sleep more than 3 or 4 hours my libido seems to get a way higher than it used to be on normal PSSD. Erecrtions are also easier to get and harder than usual. I masurbate like 3 or 4 times a day when im sleepless.
Btw there are no drugs or medicals in this relationship.

Does anybody have similar experiences? I remember time ago someone told me that when you are sleepless your dopamin system works different or something.

So when you don't sleep more than 3 or 4 hours do you masturbate with a flaccid penis or are your erections harder?
Besides i would like to ask you any other questions please:
-Can you get erected at anytime only from visual stimuly (porn) or do you need always need phisical stimulation?
-when you ejaculate your erection becomes flaccid during ejaculation or immediately after ejaculation or can be kept erect for some time (seconds / minutes)?
Thank you

[gianno121]

Everytime i dont sleep more than 3 or 4 hours my libido seems to get a way higher than it used to be on normal PSSD. Erecrtions are also easier to get and harder than usual. I masurbate like 3 or 4 times a day when im sleepless.
Btw there are no drugs or medicals in this relationship.

Does anybody have similar experiences? I remember time ago someone told me that when you are sleepless your dopamin system works different or something.

So when you don't sleep more than 3 or 4 hours do you masturbate with a flaccid penis or are your erections harder?
Besides i would like to ask you any other questions please:
-Can you get erected at anytime only from visual stimuly (porn) or do you need always need phisical stimulation?
-when you ejaculate your erection becomes flaccid during ejaculation or immediately after ejaculation or can be kept erect for some time (seconds / minutes)?
Thank you

If i sleep only 3-4 hours my erections are a way harder!
-I cant get erected just from visual stimuly, its impossible. With phisical stimulations like touching or jerking it works. With normal PSSD state i get like 60% erections with soft glans. Penis is very thin not as it used to be. With insomnia erections get 70-80%.
-In my normal PSSD state erections become completely flaccid after 1 seccond of ejaculation. With insomnia (or for me amphetamine) erections stay seconds or maybe 1-2 minutes after ejaculation.
But also my numbness improves by having less sleep and orgasm feels better and its more intensive.

The question is if everybody with PSSD expierences improvement by having less sleep. I think everybody should try it and post it here.

[Numbed]

Would like to add that I also notice huge improvement snd the desire to have sex and masturbate during both sleep deprivation and during hangovers from huge amount of alcohol

REM sleep deprivation induces dopaminergic supersensitivity
https://www.ncbi.nlm.nih.gov/pubmed/201949l.

Sleepdeprivation amplifies brain reward networks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086142/

Alcohol withdrawal/hangover:

Chronic voluntary alcohol intake hypersensitivity of 5ht1a autoreceptor
http://onlinelibrary.wiley.com/doi/10.1 ... 733.x/full

Alcohol upregulates SERT and MAO-A
https://www.ncbi.nlm.nih.gov/pubmed/19572987

Ive said this before on reddit and will say it again here, roughly 8-16hours after a drinking binge I feel 100% cured from pssd, often the morning I wake up after the binge I wake up with an incredibly sensitive erection, im talking where the slightest breeze of air gets you rock hard and about to burst.

Forgot to add: alcohol induced cyp2d6 in the brain, ginkgo also induces cyp2d6, ginkgo is well known to sensitize the brain to dopamine and increase non contact erections.

Cyp2d6 induction also offers another pathway of creating dopamine by metabolizing p-tyramine into dopamine without the conversion to l-dopa.

Pretty much all SSRI's are cyp2d6 inhibitors which makes me wonder if our pssd also involves very low cyp2d6 activity in the brain and if there is a way to create a new baseline with more cyp2d6 activity than we currently have.
This might involve long term use of a low dose of ginkgo.

[lost_soul]

Is there any way you could change the amount you sleep to induce permanent changes? Like sleeping X hours per night for Y nights, or going without sleep totally for Z nights.

[Numbed]

Well it takes about 2-4 weeks of SSRI use for the autoreceptors to downregulate (which is desired effect for major depressive disorder), im pretty sure the reversal/cure of our autoreceptors would involve none stop bombarding with a chemical for 2-4 weeks aswell.

It might sound insane but I have considered to pretty much 24/7 become intoxicated for 4 weeks straight, meaning also having an intoxicated level of alcohol in my while being asleep.

Another thing to consider is the use of chronic low dose melatonin maybe?
Melatonin is what tells the brain to go sleep and im pretty sure there will be a melatonin spillover during sleep depr.

[Numbed]

Btw lost soul with regards to your succes with beta estradiol, Im sure that you also are aware that alcohol increases E2 levels and without a doubt reaches the brain.

How do you respond to hangovers and sleep depr.?