Ketamine (Ketalar)

[Dryed]

Sure but what in reality i would to say is that beyond psychological commorbilities some of the neurological and physical issues are worse of what "simple" sexual dysfunction are... In my case (but not only in my case) after paroxetine i've got not only pssd but also chronic and extreme fatigue,prostatitis,balance issues,i've lost pheriperical vision from sx eye,can't sleep,can't rest,can't concentrate,nausea all days... And many more and even all of this i'm not depressed and neither i will be... What is really important to remember is to not minimalize in any way PSSD or PFS/PAS because they can be extreme and life altering conditions and nothing more.

[jjr81]

I agree dryed. There are levels to this. I've been hit with the worst of it. I have no emotions, no love, no empathy, no happiness, no sadness, no libido, no hunger, no imagination, no erections, completely numb genitals, shrinkage, severe insomnia, dry skin, dry eyes, etc. I'm a complete fucking zombie. Can't and won't get used to this. I can try to give it some time with Goldstein but that's all I can commit to.

[Ghost]

There's only a handful of people who have spent as much time on PSSD as myself. I've gone over it again and again in my head, trying to make sense of it.

In fact, denying the existence of PSSD is one of the rules of the forum. I mention that because of what I'm going to say next.

Everything is chemical. I've noted that since the beginning. Anything can change your gene expression, and at the end of the day dopamine is dopamine. What I'm trying to say here is that it doesn't matter if you were depressed before the SSRI or if it's worse, or if it feels different etc, what matters is that you try to treat symptoms. This is important because MOST of the symptoms noted above coincide with depression. Note that depression doesn't always mean that you are sad. For me, it often presents as anhedonia, concentration issues, restlessness, insecurities and fatigue.

Raven notes the twitches and body tension. This is something very personal to me I feel this way often. It's probably the most prominent manifestation of my OCD and anxiety. Obsessing about how I can't relax or concentrate or sleep - etc. My OCD is very physical, and that leads to risk of pelvic dysfunction.

I don't necessarily think that there is ONE PSSD, instead there might be many flavors or variants of PSSD. The way I currently see PSSD (and it's always changing) is as collection of disorders that come after taking an SSRI.

Some people develop hormone changes after SSRI (these changes can be in the brain or in the spina cord, or in the penis), and therefore respond well to Testosterone or similar therapies. This can be a very complex problem to solve Others do not respond to these treatments, or have normal blood

There is research that viruses or infections can cause nerve problems or muscular problems in the pelvis/penis. These people would respond well to treatments that cure these diseases. We've seen a few of these patients as well. These are the people that respond well to treating their guts.

There are people who I think have muscle problems from clenching or being anxious. I'm not sure how SSRIs made them worse, maybe physical damage to a muscle or maybe the person is always clenching to overcome the sexual sides of the SSRI. They might present with similar symptoms as HF or other pelvic floor disorders. Often they will pick up worsened secondary depression around their conditions. This can lead to worsening of an already fragile mental state. This is also noted in the HF community.

Then there are a group of people that I think are (quite bluntly) just too depressed or anxious to have good sex lives. Most of them take SSRIs, and correlate the worsening of their mental illness with the time that they took SRRIs. It's hard to prove this right or wrong because SSRIs and serotonin drugs that worsen sexual function are the very drugs that are often used for their depression.

And the group we've all been waiting for: People with a neurological change after SSRI.This would include serotonin/dopamine changes or something similar. Of course, we need to note that Depression or other conditions could also affect these neurotransmitters from functioning. This is where most of my work has been done up until this point. However, I have tapped into the other areas as well, and am now growing in confidence with this theory enough to pitch it to the forum at large. Obviously, it's still in its infancy, but people have suggested similar things before.

The moral of the story is that I think many people with Anhedonia can at least improve their anhedonia with depression drugs such as ketamine. This is similar to depressed people using it to treat anhedonia. Anhedonia is a chemical state in the brain, treating anhedonia is treating anhedonia - regardless of the root cause.

Then try treating the physical symptoms at the same time - viagra / pelvic therapy etc.

[Ghost]

There's only a handful of people who have spent as much time on PSSD as myself. I've gone over it again and again in my head, trying to make sense of it.

In fact, denying the existence of PSSD is one of the rules of the forum. I mention that because of what I'm going to say next.

Everything is chemical. I've noted that since the beginning. Anything can change your gene expression, and at the end of the day dopamine is dopamine. What I'm trying to say here is that it doesn't matter if you were depressed before the SSRI or if it's worse, or if it feels different etc, what matters is that you try to treat symptoms. This is important because MOST of the symptoms noted above coincide with depression. Note that depression doesn't always mean that you are sad. For me, it often presents as anhedonia, concentration issues, restlessness, insecurities and fatigue.

Raven notes the twitches and body tension. This is something very personal to me I feel this way often. It's probably the most prominent manifestation of my OCD and anxiety. Obsessing about how I can't relax or concentrate or sleep - etc. My OCD is very physical, and that leads to risk of pelvic dysfunction.

I don't necessarily think that there is ONE PSSD, instead there might be many flavors or variants of PSSD. The way I currently see PSSD (and it's always changing) is as collection of disorders that come after taking an SSRI.

Some people develop hormone changes after SSRI (these changes can be in the brain or in the spina cord, or in the penis), and therefore respond well to Testosterone or similar therapies. This can be a very complex problem to solve Others do not respond to these treatments, or have normal blood

There is research that viruses or infections can cause nerve problems or muscular problems in the pelvis/penis. These people would respond well to treatments that cure these diseases. We've seen a few of these patients as well. These are the people that respond well to treating their guts.

There are people who I think have muscle problems from clenching or being anxious. I'm not sure how SSRIs made them worse, maybe physical damage to a muscle or maybe the person is always clenching to overcome the sexual sides of the SSRI. They might present with similar symptoms as HF or other pelvic floor disorders. Often they will pick up worsened secondary depression around their conditions. This can lead to worsening of an already fragile mental state. This is also noted in the HF community.

Then there are a group of people that I think are (quite bluntly) just too depressed or anxious to have good sex lives. Most of them take SSRIs, and correlate the worsening of their mental illness with the time that they took SRRIs. It's hard to prove this right or wrong because SSRIs and serotonin drugs that worsen sexual function are the very drugs that are often used for their depression.

And the group we've all been waiting for: People with a neurological change after SSRI.This would include serotonin/dopamine changes or something similar. Of course, we need to note that Depression or other conditions could also affect these neurotransmitters from functioning. This is where most of my work has been done up until this point. However, I have tapped into the other areas as well, and am now growing in confidence with this theory enough to pitch it to the forum at large. Obviously, it's still in its infancy, but people have suggested similar things before.

The moral of the story is that I think many people with Anhedonia can at least improve their anhedonia with depression drugs such as ketamine. This is similar to depressed people using it to treat anhedonia. Anhedonia is a chemical state in the brain, treating anhedonia is treating anhedonia - regardless of the root cause.

Then try treating the physical symptoms at the same time - viagra / pelvic therapy etc.

[raven100]

agree 100%

[jjr81]

I agree for the most part Ghost. I am concerned by the fact that I don't respond to drugs and alcohol. I'm afraid that means I'm untreatable.