Search found 279 matches

by Tree
Sun Apr 14, 2024 6:12 am
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 78
Views: 79486

Re: An Excellent Explaination of How SSRI's Inhibit Sert

How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ? I don't have access to the full study. Maybe someone on this forum can access the full study for us. https://www.sciencedirect.com/science/article/abs/pii/S0378874120334899?via%3Dihub I think that’s...
by Tree
Sun Apr 14, 2024 5:58 am
Forum: Treatments and experimentation
Topic: Some weird method found on twitter
Replies: 2
Views: 278

Re: Some weird method found on twitter

Don't eat ginger it's a 5ht1a agonist it will desensitize your serotonin receptors which may cause you to crash
by Tree
Wed Apr 10, 2024 4:07 am
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 78
Views: 79486

Re: An Excellent Explaination of How SSRI's Inhibit Sert

mhugh wrote: Mon Mar 25, 2024 5:45 pm How can we aquire Desoxo-narchinol A and what would be the optimal dosage to restore SERT function ?
I don't have access to the full study. Maybe someone on this forum can access the full study for us.
by Tree
Wed Feb 21, 2024 6:06 am
Forum: Treatments and experimentation
Topic: Hypertonic Sodium Salts/Sodium Bicarb as a treatment for genital numbness
Replies: 4
Views: 1253

Re: Hypertonic Sodium Salts/Sodium Bicarb as a treatment for genital numbness

I started drinking carbonated water and I noticed an increase sensation in my genitals but after a few days it seems to have worn off followed by increased cognitive symptoms. There seems to be some support for your findings "Sertraline may inhibit 5-HTT by inhibiting Na+ channels, increasing t...
by Tree
Mon Feb 12, 2024 1:59 am
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 78
Views: 79486

Re: An Excellent Explaination of How SSRI's Inhibit Sert

desoxo-narchinol A extracted from Nardostachys jatamansi DC upregulates sert and reverses the sert inhibition of SSRIs. "Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT pot...
by Tree
Fri Feb 09, 2024 4:52 am
Forum: Treatments and experimentation
Topic: Severe PSSD Remission/Management with Ketogenic Diet and Low-Dose Lithium
Replies: 19
Views: 3665

Re: Severe PSSD Recovery with Ketogenic Diet and Low-Dose Lithium

Hello all, it’s been a while since I’ve given an update on my situation and I figured I would check back in. In the past few years I’ve been through some very low lows after a crash from memantine. After my crash, I believed that there was truly no hope left for me and that I was better off dead. A...
by Tree
Mon Jan 29, 2024 4:25 am
Forum: Treatments and experimentation
Topic: Severe PSSD Remission/Management with Ketogenic Diet and Low-Dose Lithium
Replies: 19
Views: 3665

Re: Severe PSSD Recovery with Ketogenic Diet and Low-Dose Lithium

Hello all, it’s been a while since I’ve given an update on my situation and I figured I would check back in. In the past few years I’ve been through some very low lows after a crash from memantine. After my crash, I believed that there was truly no hope left for me and that I was better off dead. A...
by Tree
Sat Jan 27, 2024 4:03 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18827

Re: Final theory of PSSD etiology. Get in here!

I do not think that taking reboxetine is the way to go. There are two ways of how desensitization works. There is heterologous desensitization where ligand no longer exert cellular response in the receptor. After this happens receptor becomes internalized. This is what i think is happening in PSSD....
by Tree
Sat Dec 23, 2023 1:45 am
Forum: Treatments and experimentation
Topic: Spyros 100% cured by Estrogen + TRT
Replies: 51
Views: 62826

Re: Spyros 100% cured by Estrogen + TRT

I'm not cured, but I improved the worst symptoms of PSSD by taking Clomid. I no longer have insomnia or that extreme tiredness that didn't allow me to get out of bed. Instead of total anorgasmia, I can have weak orgasms now. I'm going to flood my body with massive doses of HCG. 1000 IU 3 times a we...
by Tree
Sun Dec 17, 2023 2:23 am
Forum: Treatments and experimentation
Topic: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
Replies: 6
Views: 11457

Re: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes

Strange I have severe pssd with high folate blood levels and I'm super sensitive to b vitamins. I've tried inositol and niacin. Both worsen my extreme insomnia and tinnitus. Research also shows SSRIs methylate the serotonin transporter. Overmethylation symptoms are similar to PSSD symptoms too.