Search found 276 matches
- Wed Feb 21, 2024 6:06 am
- Forum: Treatments and experimentation
- Topic: Hypertonic Sodium Salts/Sodium Bicarb as a treatment for genital numbness
- Replies: 4
- Views: 1216
Re: Hypertonic Sodium Salts/Sodium Bicarb as a treatment for genital numbness
I started drinking carbonated water and I noticed an increase sensation in my genitals but after a few days it seems to have worn off followed by increased cognitive symptoms. There seems to be some support for your findings "Sertraline may inhibit 5-HTT by inhibiting Na+ channels, increasing t...
- Mon Feb 12, 2024 1:59 am
- Forum: PSSD related research
- Topic: An Excellent Explaination of How SSRI's Inhibit Sert
- Replies: 74
- Views: 78103
Re: An Excellent Explaination of How SSRI's Inhibit Sert
desoxo-narchinol A extracted from Nardostachys jatamansi DC upregulates sert and reverses the sert inhibition of SSRIs. "Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT pot...
- Fri Feb 09, 2024 4:52 am
- Forum: Treatments and experimentation
- Topic: Severe PSSD Remission/Management with Ketogenic Diet and Low-Dose Lithium
- Replies: 19
- Views: 3525
Re: Severe PSSD Recovery with Ketogenic Diet and Low-Dose Lithium
Hello all, it’s been a while since I’ve given an update on my situation and I figured I would check back in. In the past few years I’ve been through some very low lows after a crash from memantine. After my crash, I believed that there was truly no hope left for me and that I was better off dead. A...
- Mon Jan 29, 2024 4:25 am
- Forum: Treatments and experimentation
- Topic: Severe PSSD Remission/Management with Ketogenic Diet and Low-Dose Lithium
- Replies: 19
- Views: 3525
Re: Severe PSSD Recovery with Ketogenic Diet and Low-Dose Lithium
Hello all, it’s been a while since I’ve given an update on my situation and I figured I would check back in. In the past few years I’ve been through some very low lows after a crash from memantine. After my crash, I believed that there was truly no hope left for me and that I was better off dead. A...
- Sat Jan 27, 2024 4:03 am
- Forum: PSSD related research
- Topic: Final theory of PSSD etiology. Get in here!
- Replies: 85
- Views: 18667
Re: Final theory of PSSD etiology. Get in here!
I do not think that taking reboxetine is the way to go. There are two ways of how desensitization works. There is heterologous desensitization where ligand no longer exert cellular response in the receptor. After this happens receptor becomes internalized. This is what i think is happening in PSSD....
- Sat Dec 23, 2023 1:45 am
- Forum: Treatments and experimentation
- Topic: Spyros 100% cured by Estrogen + TRT
- Replies: 51
- Views: 62269
Re: Spyros 100% cured by Estrogen + TRT
I'm not cured, but I improved the worst symptoms of PSSD by taking Clomid. I no longer have insomnia or that extreme tiredness that didn't allow me to get out of bed. Instead of total anorgasmia, I can have weak orgasms now. I'm going to flood my body with massive doses of HCG. 1000 IU 3 times a we...
- Sun Dec 17, 2023 2:23 am
- Forum: Treatments and experimentation
- Topic: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
- Replies: 6
- Views: 11425
Re: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
Strange I have severe pssd with high folate blood levels and I'm super sensitive to b vitamins. I've tried inositol and niacin. Both worsen my extreme insomnia and tinnitus. Research also shows SSRIs methylate the serotonin transporter. Overmethylation symptoms are similar to PSSD symptoms too.
- Thu Nov 30, 2023 11:06 pm
- Forum: General
- Topic: I can probably help you improve your symptoms
- Replies: 22
- Views: 7400
Re: I can probably help you improve your symptoms
There seems to be some interaction with 5ht1a receptors so I'd be cautious.heymartinn wrote: ↑Thu Nov 30, 2023 9:19 amIs it though? All I can find is antagonism against several 5HT subtypes but no mention of 5HT1A agonism
https://pubmed.ncbi.nlm.nih.gov/29859012/
- Thu Nov 30, 2023 12:46 am
- Forum: General
- Topic: I can probably help you improve your symptoms
- Replies: 22
- Views: 7400
Re: I can probably help you improve your symptoms
I can’t remember for sure, but I’m almost positive I have. Of course you can try it without the naltrexone, but if it doesn’t give you significant improvements, you can always try the naltrexone. This is the only thing that worked for me in any permanent way, and it worked very quickly too. You cla...
- Wed Nov 29, 2023 9:49 pm
- Forum: General
- Topic: I can probably help you improve your symptoms
- Replies: 22
- Views: 7400
Re: I can probably help you improve your symptoms
Op have you tried the hoppy beer without Naltrexone? I'm very skeptical that Naltrexone can help pssd from the research I've done. Alcohol on the other hand can possibly reverse some of the structural epigenetic changes caused by SSRIs.