Search found 287 matches

by kpavel
Wed Jun 02, 2021 4:12 pm
Forum: General
Topic: Alkohol withdrawal
Replies: 6
Views: 340

Re: Alkohol withdrawal

dzidektancerz wrote: Wed Jun 02, 2021 9:02 am I just feel great next day after alkohol consumption. Any idea what giving similar effect without drinking every day ?
Perhaps sleeping 5 hours instead of 7-9 acutely gives a bit of similar sensation change for me.
by kpavel
Sat May 08, 2021 3:32 am
Forum: Polls
Topic: Orgasms' pleasure intensity (while on SRIs)
Replies: 12
Views: 1005

Re: Orgasms' pleasure intensity (while on SRIs)

I had a small period of highly increased orgasm intensity a few months into pssd (from 5htp).

About oxytocin, some rumor appeared on reddit about L.Reuteri.
by kpavel
Wed May 05, 2021 4:22 am
Forum: General
Topic: Reading comprehension issues
Replies: 4
Views: 381

Re: Reading comprehension issues

It's serotonin 5-ht2b receptors that probably harm proper prefrontal cortex work (I assume this is the problem). And another drug which you can get not only from Russia is Metadoxine. Basically it's pyroglutamic acid (which is key and you can buy separately, it's natural compound close to piracetam)...
by kpavel
Fri Apr 23, 2021 2:37 pm
Forum: Speculations and hypotheses
Topic: Melasma in PFS and raised DNMT1 in melasma, possible restoration of SERT with SIRT1
Replies: 5
Views: 811

Re: Melasma in PFS and raised DNMT1 in melasma, possible restoration of SERT with SIRT1

Interesting, thanks for the good research. Ssri's inhibit sert function by reduction of sert binding sites. A reduction in sert mrna gene expression doesn't reduce sert binding sites induced by ssri. An increase in sert mrna expression, however, may possibly upregulate sert binding density. Chronic...
by kpavel
Fri Apr 23, 2021 1:47 pm
Forum: Speculations and hypotheses
Topic: Melasma in PFS and raised DNMT1 in melasma, possible restoration of SERT with SIRT1
Replies: 5
Views: 811

Re: Melasma in PFS and raised DNMT1 in melasma, possible restoration of SERT with SIRT1

These guys say regular nicotinamide inhibits sirt1, but nicotinamide riboside and nicotinamide mononucleotide raise it? Not sure what to make of it... What do you think the best form to take would be? https://www.longecity.org/forum/topic/101100-nicotinamide-raises-nad-and-is-much-cheaper-so-why-bo...
by kpavel
Wed Apr 07, 2021 9:21 am
Forum: PSSD related research
Topic: The true nature of an autoimmune disease 2021. Herpesviridae infection
Replies: 9
Views: 812

Re: The true nature of an autoimmune disease 2021. Herpesviridae infection

Interestingly enough GH protects elders from infection Aging and immune function: a possible role for growth hormone https://pubmed.ncbi.nlm.nih.gov/8742118/ Elderly individuals have four to five times the case rate of cancer, tuberculosis and herpes zoster and six to seven times the fatality rate f...
by kpavel
Wed Apr 07, 2021 8:38 am
Forum: PSSD related research
Topic: The true nature of an autoimmune disease 2021. Herpesviridae infection
Replies: 9
Views: 812

Re: The true nature of an autoimmune disease 2021. Herpesviridae infection

Polyamines have a promising and interesting place in solving autoimmune diseases. Viruses as well as bacterias can consume and produce them. Their production also needs s-adenosylmethionine. They counteract cell apoptosis and stimulate cel autophagy. Hormones such as testosterone, estrogen, growth h...
by kpavel
Wed Mar 31, 2021 10:28 am
Forum: Treatments and experimentation
Topic: Getting great results from my multivitamins for mood, brain fog and libido, but I’m not sure what does the trick.
Replies: 9
Views: 1071

Re: Getting great results from my multivitamins for mood, brain fog and libido, but I’m not sure what does the trick.

In my exprerience I associate 'true' increases in sensation with pyridoxal phosphate (sublinqual) and selenium (200-400 mcg), alpha lipoic acid is interesting. Well, its is possible to use B6 vitamin to lower prolactin levels. However, after reading about Vitamin B6 poisoning I'm now rather cautiou...
by kpavel
Wed Mar 31, 2021 2:26 am
Forum: Treatments and experimentation
Topic: Getting great results from my multivitamins for mood, brain fog and libido, but I’m not sure what does the trick.
Replies: 9
Views: 1071

Re: Getting great results from my multivitamins for mood, brain fog and libido, but I’m not sure what does the trick.

Well, its is possible to use B6 vitamin to lower prolactin levels. However, after reading about Vitamin B6 poisoning I'm now rather cautious with that. There are dreadful tries on Reddit of people who got that from supplements; apparently as low as 20mg per day. But p5p appears safer. https://en.wi...
by kpavel
Mon Mar 29, 2021 10:34 pm
Forum: Treatments and experimentation
Topic: Getting great results from my multivitamins for mood, brain fog and libido, but I’m not sure what does the trick.
Replies: 9
Views: 1071

Re: Getting great results from my multivitamins for mood, brain fog and libido, but I’m not sure what does the trick.

Currently taking Life Extension two-per-day, and actually taking only once capsule every two day, so ¼ of the dose, and I’m feeling much better. Better libido, erection quality, genital sensation, less brain fog, better mood and drive. https://www.amazon.com/Life-Extension-Potency-Multi-Vitamin-Sup...