Search found 6 matches

by LeaveMeAlone
Tue Sep 27, 2022 5:55 am
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 85
Views: 88101

Re: An Excellent Explaination of How SSRI's Inhibit Sert

fluvoxamine increases Akt-phosphorylation through sigma1-receptors [180,181], while sertraline decreases it [182]. Sertraline inhibition of Akt leads to more gsk3b expression which causes less canonical wnt activation and decrease sert expression through changes in microrna. It probably explains wh...
by LeaveMeAlone
Mon Oct 12, 2020 5:44 am
Forum: Treatments and experimentation
Topic: Success report of someone using St. John's Wort Ze 117 (0.2% hyperforin)
Replies: 3
Views: 1131

Re: Success report of someone using St. John's Wort Ze 117 (0.2% hyperforin)

the benefits were temporary and didn't cure him
he got pssd from ashwagandha which alters 5ht1a
by LeaveMeAlone
Thu May 07, 2020 12:59 pm
Forum: Treatments and experimentation
Topic: Inositol or SJW ?
Replies: 2
Views: 1051

Inositol or SJW ?

I took Maprotiline 10 mg( micro dose) for 5 days 6 months ago which is a 5HT2A antagonist, so I don't think I have 5HT1A desensitization because i took a really small dose for a short time. my symptoms are emotional numbness, fatigue, severe brain fog and sexual dysfunction( thick semen, lower libid...
by LeaveMeAlone
Wed Jan 15, 2020 1:08 pm
Forum: Treatments and experimentation
Topic: should I take or stay away from Testosterone Injections ?
Replies: 11
Views: 3241

Re: should I take or stay away from Testosterone Injections ?

will it shut down sperm production 3 times in 9 weeks ? (for short-term use only)
by LeaveMeAlone
Tue Jan 14, 2020 11:50 pm
Forum: Treatments and experimentation
Topic: should I take or stay away from Testosterone Injections ?
Replies: 11
Views: 3241

Re: should I take or stay away from Testosterone Injections ?

I was on ludiomil (TCA) 10mg for 5 days then stopped takning it and I got pssd and anhedonia since then. one month later I took Escitalopra 5mg for 3 days and stopped taking it too because it made me nervous. it has been 3 months I have't taken anything. my erection and genital numbness improved but...
by LeaveMeAlone
Tue Jan 14, 2020 4:01 pm
Forum: Treatments and experimentation
Topic: should I take or stay away from Testosterone Injections ?
Replies: 11
Views: 3241

should I take or stay away from Testosterone Injections ?

I am 21M shbg : 24.81 nmol/l Free Testosterone : 0.901 nmol/l Total Testosterone : 22.36 nmol/l Vitamin D3 : 38.58 ng/ml Vitamin B12: 172.4 pg/ml My symptoms : Low sex drive anhedonia and Emotional blunting/ numbness ( cant feel fear, love, hate, happiness, sadness) back muscle pain. low energy weak...