Search found 21 matches

by Calm Amygdala
Thu May 27, 2021 4:29 pm
Forum: Treatments and experimentation
Topic: Reports of use of mirtazapine
Replies: 14
Views: 3980

Re: Reports of use of mirtazapine

My hope is i can get good improvements in depression/pssd from mirtazapine without anxiety. Its noradrenergic activity can cause anxiety in me, as it has in the past. but ive never tried low dose. Looking to capitalize on its activty at 5ht1a, 2a, and 2c for depression/pssd
by Calm Amygdala
Thu May 27, 2021 3:33 pm
Forum: Treatments and experimentation
Topic: Reports of use of mirtazapine
Replies: 14
Views: 3980

Re: Reports of use of mirtazapine

really, that is fascinating. i am undergoing ketamine treatment right now and am noticing a worsening of symptoms. Does your ketamine doc give you ondansetron before sessions? I have found 5ht3 antagonists worsen my symptoms substantially and i think the worsening of symptoms may be due to the ondan...
by Calm Amygdala
Tue May 25, 2021 2:27 pm
Forum: Treatments and experimentation
Topic: Reports of use of mirtazapine
Replies: 14
Views: 3980

Re: Reports of use of mirtazapine

What benefits did you experience in regards to both depression and pssd? I'm consideringtrying 7.5 mg for help with depression/pssd

Also, have you experienced any rebound depression/pssd since coming off? Did you switch to something else or just stop mirtazapine?
by Calm Amygdala
Mon May 24, 2021 10:48 pm
Forum: Treatments and experimentation
Topic: Reports of use of mirtazapine
Replies: 14
Views: 3980

Re: Reports of use of mirtazapine

sovietxrobot wrote: Wed Mar 03, 2021 11:19 am Its an antagonist of 5ht2a and 2c so it sounds reasonable for treatment of PSSD. In practice it wasn't as good as I had hoped. It gave me some symptom relief that faded quickly. I'm quitting now because the weight gain is intolerable.
how much weight gain did it cause and what dosage were you on?
by Calm Amygdala
Mon May 24, 2021 10:24 pm
Forum: General
Topic: Kava Kava
Replies: 1
Views: 996

Re: Kava Kava

does zero for pssd. maybe even makes it worse
by Calm Amygdala
Mon May 24, 2021 7:23 pm
Forum: Treatments and experimentation
Topic: Experience with Kratom?
Replies: 5
Views: 1933

Re: Experience with Kratom?

kratom crashes me hard
by Calm Amygdala
Sat May 22, 2021 10:20 pm
Forum: Treatments and experimentation
Topic: My theory
Replies: 26
Views: 6878

Re: My theory

So if it’s more about signaling and not amount available how do we correct that? If you guys are right, what is to be done, what do we try? I think several of us would be willing to test this theory if we knew what to try. I would have to monitor your results individually, after making a few sugges...
by Calm Amygdala
Fri May 21, 2021 1:36 am
Forum: Speculations and hypotheses
Topic: Very very soft penis
Replies: 7
Views: 2847

Re: Very very soft penis

how to treat it?
by Calm Amygdala
Fri May 21, 2021 1:22 am
Forum: Speculations and hypotheses
Topic: Postsynaptic AMPA receptor upregulation?
Replies: 12
Views: 5059

Re: Postsynaptic AMPA receptor upregulation?

Any updates on this? Fascinating thread. Meso, are you saying that metformin would block the antidepressant effects of ketamine?
by Calm Amygdala
Fri May 07, 2021 8:42 pm
Forum: Treatments and experimentation
Topic: Thoughts on 5HT1A antagonists?
Replies: 52
Views: 12592

Re: Thoughts on 5HT1A antagonists?

5ht1a antagonists will probably not sensitize the receptor because there is a large concentration of serotonin in our synapses from sert down regulation. Antagonists will just increase 5ht firing, by blocking 5ht1a receptors, which will worsen symptoms. We need to focus on finding ways to upregulat...