Water restriction probably increases metabolism and thyroid hormones.

A selenium supplement could be important.

Maybe osmolytes (inositol belong to this family by the way) could help you as they are used by the body to counter osmotic stress.

https://open.substack.com/pub/leadtheway/p/osmolytes

Seems like as good a lead as any! I've recently been trying to exercise more, I'll work in some other things to try and increase my BDNF however I can. Do you have any recommendations? Disclaimer: I might be biased on this one. Sometimes I wonder whether exercise benefits aren't mostly coming from ...

Hi, My symptoms tend to come and go but if I have to give the most important ones: - anhedonia; - fatigue/low energy; - brain fog at times; - rather low libido but not always; - something akin to metabolic syndrome (obesity, hair loss). I've tried to treat myself with a collection of supplements: B ...

Hi, I've just read on BDNF (Brain-Derived Neurotrophic Factor) and it could play a role in dopamine circuits and could also be acted upon by antidepressants. Maybe a good topic to research. Also, inositol is an osmolyte (a molecule that helps counter osmotic stress) and I believe it's on this basis ...

I'm not sure whether OP is still active on this forum but I think his idea has merit. The homeostasis of water seems to be linked to energy (for example, vasopressin and oxytocin are linked to thyroid and thermogenesis), detoxification pathways (the glymphatic system, detoxification enzymes), neurot...

Hi, I've not taken any antidepressant in my life but had a prescription of finasteride years ago and had to stop because of the pain. I do not consider myself a severe case of PFS at all but am interested in this constellation of diseases (and Chronic Fatigue Syndrome as well). I would like to parti...