Search found 421 matches

by magnilo
Mon Apr 17, 2023 1:51 am
Forum: Treatments and experimentation
Topic: PSSD-SSRI-Depression-Anhedonia = my idea of cause and cure.
Replies: 56
Views: 40762

Re: PSSD-SSRI-Depression-Anhedonia = my idea of cause and cure.

I take isotretinoin, about 10mg every three days, half a year on half a year off l, I've also had almost tel years where I didn't take it and to be honest there is no tangible difference on sexual function. I'm aware of all the associated risks, but I trialled it and the benefits are too big, consid...
by magnilo
Tue Jan 10, 2023 6:49 am
Forum: General
Topic: What are your thoughts on vortioxetine/Trintellix/Brintellix?
Replies: 6
Views: 1279

Re: What are your thoughts on vortioxetine/Trintellix/Brintellix?

But yeah you bring up a good point, in the study they mention that vortioxetine shifts the serotonin dopamine balance, but nowhere is explained the mechanism of action of said activity. What I know from other sources is that vortioxetine has no effect on d receptors but indirectly raised dopamine vi...
by magnilo
Tue Jan 10, 2023 6:45 am
Forum: General
Topic: What are your thoughts on vortioxetine/Trintellix/Brintellix?
Replies: 6
Views: 1279

Re: What are your thoughts on vortioxetine/Trintellix/Brintellix?

I think we must accept that what we call pssd is in fact originated from many very different molecules, medications or not. Someone took something that caused "pssd", and it may be improved by taking certain medications. It's very likely that there isn't an antidote, but many different med...
by magnilo
Tue Jan 10, 2023 2:27 am
Forum: General
Topic: What are your thoughts on vortioxetine/Trintellix/Brintellix?
Replies: 6
Views: 1279

Re: What are your thoughts on vortioxetine/Trintellix/Brintellix?

There's a recent paper titled 'Cutting the first turf to heal post ssri sexual dysfunction: a male retrospective cohort study' by Rosario De Luca, Mirjam Bonanno et al. This paper seems to suggest that vorteoxetine lead to more improvements in the participants than some more commonly tried drugs su...
by magnilo
Thu Sep 08, 2022 5:16 am
Forum: Treatments and experimentation
Topic: Trazodone
Replies: 30
Views: 5444

Re: Trazodone

First week of 25mg trazodone in the evening and 150mg bupoprion xr at lunch: feeling subtly different perception wise but nothing I can describe accurately or particularly tangible. As of now it has no effect on any sexual parameters. On the other hand the side effects of the two meds do cancel each...
by magnilo
Fri Sep 02, 2022 2:07 pm
Forum: Treatments and experimentation
Topic: Trazodone
Replies: 30
Views: 5444

Re: Trazodone

Trazodone may be effective in the treatment of sexual dysfunction, for instance female sexual dysfunction and erectile dysfunction. A 2003 systematic review and meta-analysis found some indication that trazodone may be useful in the treatment of erectile dysfunction. Besides trazodone alone, a comb...
by magnilo
Fri Sep 02, 2022 11:21 am
Forum: Treatments and experimentation
Topic: Trazodone
Replies: 30
Views: 5444

Re: Trazodone

What i meant is that trazodone and bupoprion are the only antidepressants that are reported to increase libido and erectyle function: so on top of the list of the things to try when one's already screwed anyway :) Vortioxetine can also be seen as a weird ssri, but has basically no side effects on se...
by magnilo
Fri Sep 02, 2022 5:59 am
Forum: Treatments and experimentation
Topic: Trazodone
Replies: 30
Views: 5444

Re: Trazodone

i wouldnt say trazodone is on top of the risky things list: of course one can try all the "holistic adaptogenic" supps that do little to nothing, but when it comes to patented molecules i think trazodone and bupropion are literally in top of the "try-this-first" list... on the ot...
by magnilo
Tue Aug 30, 2022 3:03 pm
Forum: Treatments and experimentation
Topic: Trazodone
Replies: 30
Views: 5444

Re: Trazodone

very interested in the trazodone bupoprion combo, has anyone tried it? in theory it would be very convenient and could synergize very well
by magnilo
Wed Jul 20, 2022 11:25 am
Forum: Treatments and experimentation
Topic: Low doses amisulpride/flupentixolum/sulpiride
Replies: 11
Views: 4848

Re: Low doses amisulpride/flupentixolum/sulpiride

I think I'd like to try this jn low doses, so I'm bumping this thread: has anyone more experiences to share?