Search found 694 matches
- Tue Mar 26, 2024 10:03 am
- Forum: PSSD related research
- Topic: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
- Replies: 4
- Views: 289
Re: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
Thanks, that's interesting! It gives us hope! That said, PIEZO2 might not be involved in the pleasure of sensations : In clinical evaluations and surveys, three men and two women with PIEZO2-deficiency syndrome reported severe hyposensitivity in genital sensation. Despite their marked mechanosensor...
- Tue Mar 26, 2024 5:36 am
- Forum: PSSD related research
- Topic: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
- Replies: 4
- Views: 289
Re: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
The Form and Function of PIEZO2 (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794004/ "Given that PIEZO2 has several physiological roles, even if selective agonists and/or antagonists are identified, systemic drug delivery methods may not safely treat a single function in isolation. Inco...
- Tue Mar 26, 2024 4:39 am
- Forum: PSSD related research
- Topic: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
- Replies: 4
- Views: 289
Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
from a previous article: "PIEZO2 function is needed for triggering a touch-evoked erection reflex and successful mating in both male and female mice. Humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration" ...
- Mon Mar 11, 2024 10:29 am
- Forum: PSSD related research
- Topic: Neuropathy and genital fibrosis, hypothesis and speculation on PSSD
- Replies: 0
- Views: 246
Neuropathy and genital fibrosis, hypothesis and speculation on PSSD
Patients with PSSD show on average high rates of genital fibrosis, or scar tissue, which can cause or worsen symptoms of erectile dysfunction and genital numbness. Clinical studies on patients with PSSD about it: - Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J. Penile anesthesia in Pos...
- Thu Feb 29, 2024 5:01 am
- Forum: PSSD related research
- Topic: Results of a new study on genital/peripheral nerve treatment of patients with PSSD, PFS and PAS
- Replies: 2
- Views: 1098
Results of a new study on genital/peripheral nerve treatment of patients with PSSD, PFS and PAS
Dr Kenneth M Peters, urologist at Beaumont Hospital, Royal Oak, Michigan, on 23 February 2024 anticipates the results of a forthcoming study on Twitter https://twitter.com/KennethMPeters1/status/1761131131376681245 NM094 | POST-RETINOID, POST-FINASTERIDE AND POST-SSRI SYNDROMES: PATIENT EVALUATION A...
- Thu Nov 23, 2023 12:50 pm
- Forum: General
- Topic: POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE
- Replies: 0
- Views: 18388
POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE
Frontiers in Neuroendocrinology Available online 21 November 2023, 101114 POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Roberto Cosimo Melcangi Dipartimento di Scienze Farmacologic...
- Fri Nov 10, 2023 2:40 am
- Forum: General
- Topic: Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-se....
- Replies: 0
- Views: 16280
Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-se....
Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US AUTHORS Yassie Pirani Jorge Andres Delgado-Ron Pedro Marino Dr. Amit Gupta Emily Gray Sarah Watt Kinnon R MacKin...
- Fri Nov 10, 2023 2:35 am
- Forum: General
- Topic: New York Times: After Antidepressants, a Loss of Sexuality. Nov 9, 2023
- Replies: 0
- Views: 16486
- Wed Sep 27, 2023 5:09 am
- Forum: PSSD related research
- Topic: Sexual touch - (PIEZO2)
- Replies: 3
- Views: 5806
Re: Sexual touch - (PIEZO2)
I contacted an author of the latest study on piezo2 and sexual function; he has not yet responded, however, I passed the study to Melcangi and he replied that PIEZO2 is already under their attention and they are getting data for both finasteride and SSRI :!: These are long analyses and it takes time...
- Sun Sep 24, 2023 3:20 am
- Forum: PSSD related research
- Topic: Sexual touch - (PIEZO2)
- Replies: 3
- Views: 5806
Re: Sexual touch - (PIEZO2)
Good vibrations The role of a mechanosensitive ion channel in sexual behavior is unveiled ARLENE J. GEORGE AND VICTORIA E. ABRAIRA https://www.science.org/doi/full/10.1126/science.adj8674 Lam et al. (1) reveal the necessity of PIEZO2 for sexual touch and copulation in mice and humans. Their results ...