Masturbation can be playing with levels of arousal and stimulation to feel more pleasure, but there are men who are less libidinous or less sensitive by nature for whom masturbation is more trivially aimed at unloading the testicles by releasing tension with a pleasure that is intense only at the m...

Thanks, that's interesting! It gives us hope! That said, PIEZO2 might not be involved in the pleasure of sensations : In clinical evaluations and surveys, three men and two women with PIEZO2-deficiency syndrome reported severe hyposensitivity in genital sensation. Despite their marked mechanosensor...

The Form and Function of PIEZO2 (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794004/ "Given that PIEZO2 has several physiological roles, even if selective agonists and/or antagonists are identified, systemic drug delivery methods may not safely treat a single function in isolation. Inco...

from a previous article: "PIEZO2 function is needed for triggering a touch-evoked erection reflex and successful mating in both male and female mice. Humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration" ...

Patients with PSSD show on average high rates of genital fibrosis, or scar tissue, which can cause or worsen symptoms of erectile dysfunction and genital numbness. Clinical studies on patients with PSSD about it: - Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J. Penile anesthesia in Pos...

Dr Kenneth M Peters, urologist at Beaumont Hospital, Royal Oak, Michigan, on 23 February 2024 anticipates the results of a forthcoming study on Twitter https://twitter.com/KennethMPeters1/status/1761131131376681245 NM094 | POST-RETINOID, POST-FINASTERIDE AND POST-SSRI SYNDROMES: PATIENT EVALUATION A...

Frontiers in Neuroendocrinology Available online 21 November 2023, 101114 POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Roberto Cosimo Melcangi Dipartimento di Scienze Farmacologic...

Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US AUTHORS Yassie Pirani Jorge Andres Delgado-Ron Pedro Marino Dr. Amit Gupta Emily Gray Sarah Watt Kinnon R MacKin...

I contacted an author of the latest study on piezo2 and sexual function; he has not yet responded, however, I passed the study to Melcangi and he replied that PIEZO2 is already under their attention and they are getting data for both finasteride and SSRI :!: These are long analyses and it takes time...