id be very careful. levonorgestrel gave me immediate shrinkage, low libido and cortisol responds (or at least an energy surge). took me a small week to recover. i took 1/6 of a pill Do you think low dose progesterone cream would be more appropriate to achieving this goal? Any way to downregulate pr...

So, I'm currently trialing Donepezil with some success for PSSD. But I've been suspecting something for a while: ever since I developed PSSD, I lost my response to nicotine and smoking, quite abruptly too. I read that Venlafaxine (my poison) upregulates 3-HSD expression. This results in higher proge...

3rd day on Donepezil @ 2.5 mg. All my symptoms keep on improving: - Flattened affect: I'm noticing an increase in sociability. I reached out to a couple of friends and had a chat. I notice a mild increase in empathy and caring. But my emotions are still largely blunted, but at least they are not fl...

A bit of history is in order, I guess: I tried a plethora of drugs to combat blunted affect (whilst on and off Venlafaxine), RBD, anhedonia, and sleep disorder both on my own and with the help of my psychiatrist: Methylphenidate, Buspirione, Amisulpride, Baclofen, Memantine, Pramipexole, Piribedil, ...

I took 2.5 mg Donepezil yesterday. An hour later, I regained some emotional reactivity to the point of eyes tearing up when I remembered my late best friend. This is the first time in a year or more that I feel an emotion other than anger. The derealization I've been experiencing post-Venlafaxine ha...

The Bethanechol thread encouraged me to try Donepezil. My PSSD is the result of Clomipramine (Anafranil) + Venlafaxine (Effexor). I was on these drugs for depression and to block RBD dysphoric dreams and morning headaches. I've been suffering from REM sleep behavioral disorder (RBD) prior to any SRI...