heymartinn wrote: ↑Thu Nov 30, 2023 9:19 am

Tree wrote: ↑Thu Nov 30, 2023 12:46 am Naltrexone is a 5-HT1A agonist

Is it though? All I can find is antagonism against several 5HT subtypes but no mention of 5HT1A agonism

There seems to be some interaction with 5ht1a receptors so I'd be cautious.

https://pubmed.ncbi.nlm.nih.gov/29859012/

I can’t remember for sure, but I’m almost positive I have. Of course you can try it without the naltrexone, but if it doesn’t give you significant improvements, you can always try the naltrexone. This is the only thing that worked for me in any permanent way, and it worked very quickly too. You cla...

Op have you tried the hoppy beer without Naltrexone? I'm very skeptical that Naltrexone can help pssd from the research I've done. Alcohol on the other hand can possibly reverse some of the structural epigenetic changes caused by SSRIs.

"Individuals receiving citalopram only showed an increase in the expression of mir-16 while administration of sertraline led to a significant increase in the expression of mir-16 and a decrease in mir-124 and mir-132 (P<0.05)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311976/

"Fluoxetine suppressed a LiCl-induced increase of total β-catenin and a LiCl-induced decrease of phosphorylated β-catenin in a dose-dependent manner" "fluoxetine enhanced binding of β-catenin with Axin1, which is a scaffold protein forming the degradation complex for β-catenin." ...

Sertraline gave me extreme insomnia too I have no tired sensation anymore and wake up not feeling rested

Weed will only make condition worse with chronic use because it increases serotonin and agonizes 5ht1a receptors. 5ht1a agonism along with elevated serotonin desensitizes receptors which causes pssd symptoms to worsen.

The up-regulation of miR-16 and the down-regulation of pre/pri–miR-16 triggered by fluoxetine in raphe were both eliminated by either Wnt3a, LiCl, or SB-216763

https://www.science.org/doi/10.1126/science.1193692

Here we see the chronic effects on the brain's serotonin system where the feedback 5-HT1A is internalized/desensitized and damaged by uncoupling from it's g-protein and losing part of it's function. But these recover after discontinuation, only the transporter SERT is actually degraded over time and...

Any experiences with vitamin A besides op? I'm curious to try because I believe sert dysfunction causes pssd. I experienced worsening symptoms from taking inositol. "13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitr...