Any updates or new trials?

https://en.wikipedia.org/wiki/Cyclothiazide "a positive allosteric modulator of the AMPA " (more glutamate) "eliminating rapid desensitization of the (AMPA) receptor" receptor more sensitive "GABAA receptor negative allosteric modulator" = more non contact erections htt...

Berberine and evodiamine are supposed to upregulate SERT mrna, with SERT downregulation an actually documented effect of serotonin related anti depressants. https://pubmed.ncbi.nlm.nih.gov/21647174/ I personally cant stand that "gut theory" of pssd. Max cringe and so forced. Total distract...

dosp35 wrote: ↑Mon Aug 30, 2021 12:20 am I’m waiting for my Inositol supplement to arrive. If it works for PSSD, I’ll update you.

so update us

https://pubmed.ncbi.nlm.nih.gov/8131066/ Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization Have you tried lithium, sjw or inositol? If so what did you experience? -Myo-Inositol 2 grams increased erections and libido a bit 30-35%, one day after takin...

Any update on the results of Fenclonine? Plz dm about a possible source.

Have you tried TRT to get your testosterone levels up? its irresponsible to suggest this without mentioning that your nuts shrink on TRT alone, over time. Please try to be less destructive in your advice. You'll want to try a mix of HCG and TRT to keep your natural Testosterone production from cras...

We want to try to activate wnt in the brain, particularly in the dorsal raphe, but can't find anything that does yet. I'm going to microdose simovastin when it arrives which will probably be sometime later this month or February. It activates wnt in the hippocampus in mice so it might activate in t...

https://pubmed.ncbi.nlm.nih.gov/8131066/
Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization

@Tree This says simvastatin inhibits wnt: https://www.mdpi.com/1420-3049/24/9/1782/htm "Simvastatin was found to attenuate H2O2-induced human umbilical vein endothelial cells (HUVECs) dysfunction and inhibit the Wnt/β-catenin pathway" This says simvastain activates wnt: https://app.dimensi...