I have done some more single doses. But it's always flippin back.
No further permanent gains. I suspect some 5-ht1a agonist-like mechanism.

Depletion of PIP2 is also desensitizing TRPV1 channels.

https://en.wikipedia.org/wiki/TRPV1

This explains some more things.

If you are on brintellix, how can you even say that the effects are still from syrian rue and not caused by 5-ht1a agonist mechanism of brintellix?

Syrian Rue Seeds should be fine.

Hi gurkhin,

how are you doing? Have you done some more doses?

Is there tyramine diet needed when taking syrian rue?

Thank you

http://www.pssdforum.com/viewtopic.php?f=21&t=278
http://www.pssdforum.com/viewtopic.php?f=10&t=573
http://www.pssdforum.com/viewtopic.php?f=10&t=569
http://www.pssdforum.com/viewtopic.php?f=10&t=583

+alot of intros

Come on, please use the search function.

Here comes a quick update. I got permanent improvement from this experiment like +20% to baseline. I also found out now that such a single dose of 2.5mg is enough to induce an huge 4 days window of feeling normal - emotional and sexual. On the day of intake i get little worse and feeling of serotoni...

Welcome gurkhin and thanks for posting. I'm not sure if get this rigth, are you talking about permanent effects? And strangely enough I found evidence in a study done on chronic users of Ayahuasca in Brazil. It was found that they had a significantly higher amount of 5HT-receptors in their blood pla...

HalfPerson wrote: PS: and what is 'serotonin face'? I know I seem to get 'serotonin bad back'. But 'serotonin face'?

red face is about histamine, if i'm right.