Psychedelics work by activating the 5HT2A-mGluR2 heterocomplex, leading to inhibition of mGluR2. Since it's an autoreceptor, this causes increased phasic glutamate firing, activating glutamate receptors. Antidepressant can downregulate 5HT2A receptor and the excitatory tone of the brain. Thank you....

The depression should slowly lift. My first year with PSSD was miserable. It's been uphill since. Just take it a day at a time. Days start adding up quickly before you know it. Sometimes in life the goal is simply surviving and that is enough. We're evolved as humans to survive at all costs. I have...

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I noticed I can not take naps anymore and I dont feel "tired" anymore.

Dryed wrote:GABA downregulation

Why do you think this is it? Also can you reverse it?

I was able to trip from the same batch before Venlaflaxine. To be 100% sure, I will be dosing again in a few weeks, this time with another batch.

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