This is probably 5ht2a and not 5ht1a. If it increases 5ht2a, it behaves similar to mianserin. I have very fond memories of metergoline, but for u it worked less like clomipramine after a long time of taking it. The acute dose of metergoline mimicked my chronic CMI intake. This 5ht2a antagonism is re...

In its current state, metergoline turns away my 2 basic problems in no time. But this is an ad hoc method.

I think I can work on PSSD again now. Crossing your fingers that he won't catch covid anymore. I am fully vaccinated and today I received the results that I got immunity. Fortunately, my PSSD seems to be reversible! And it may be due to changes in receptors. I believe he suffers from PSSD and DAWS a...

I had the same crash. Identical like you!

I also felt severe anxiety on reboxetine (I had taken it before PSSD) but it didn't seem to come from the adrenergic system. It resembled mild PSSD / 5ht2 activation symptoms, so I thought nicotinic antagonist or girk blockade had this effect.) The other NRIs did not have such a noticeable anxiogeni...

I have a tragic reaction to lithium, it made me permanently worsen my PSSD (like the mianserin or escitalopram that triggered my PSSD). I felt similar on the withdrawal of tryptophan depletion (exinstential tortures).

I wouldn't say norepinephrine is anxiety. In my case, the alpha 1 adrenergic stimulation causes an effect similar to carbamazepine- anti depressant and anti OCD + better memory and focus. Perfect for people with mild attention deficit. I think reboxetine is a nice drug, just take it with the alpha 2...

Escitalopram has some interaction with the endocannabinoid system, possibly escitalopram-induced PSSD includes CB1 desensitization. Because the CB1 antagonist seems to reverse the process, but I don't know if you could handle it. 5ht1a and CB1 receptors most strongly inhibit existential terror in th...

I found that they are needed to perceive that life has "meaning" their activation (alpha1 also) immediately removes the feeling of "robotrippy anhedonia" and causes "strong emotion and creativity". I am an artist and AMPAkines was a storm of ideas for me. Probably anhed...

Alpha 1 adrenergic receptors are also strong release IP3 and AMPA glutamate receptor activation appear activate both group: alpha1 adrenergic+5ht2 recptors in medial prefrontal cortex. I tryed AMPAkines and alpha 1 agonist and I noticed a familiar effect similar to carbamazepine ( reduction carbamaz...