I really liked Agomelatine. It consistently gave me a warm and pleasant feeling every night I took it. For several years. I only took it 5 days a week, maybe that stopped tolerance. Definitely helped with anhedonia but not emotional numbness I think. This was just acute effects after taking the pill...

16- Pitolisant: H3 receptor inverse agonist. This increases monoamine transmission by quite a bit. 17- Etifoxine: Multi-acting as a GABA-A positive allosteric modulator + increases natural production of neurosteroids + possible translocator protein (TSPO) agonist (helpful for chronic fatigue syndro...

Has anybody tried Chaihu-jia-Longgu-Muli or Yueju pill? Sounds promising for depression. I feel like I have to mention that they both have significant, perhaps strong CYP3a4 inhibition. At least in vitro. That means alot of drug interactions. I want to try it soon, I just have to change my regimen s...

@meso Let’s say someone got primarily emotional blunting, moderate anhedonia and some cognitive impairment, but also decreased libido and inability to feel love + low/no response to drugs like alcohol and cannabis. That person have also gotten windows from low dose metergoline. Would semax and lithi...

Hello Meso

I read you say that lithium could potentially reverse epigenetic changes done by weed. Could this be changes done 10 years ago in late adolescence like social and cognitive impairment and social anhedonia?

You must take the BCAA with either l-tyrosine or l-phenylalanine, otherwise you will deplete dopamine along with serotonin which might cause a depressed mood and fatigue. If you go with l-tyrosine, studies show that it only gets converted to dopamine if your retina is exposed to direct sunlight. It ...