I am not a big fan neither of "simple" theories such as "it's all due to this receptor" nor of animal studies, but I am surprised nobody mentioned ginkgo biloba here, although there are lots of animal studies showing its potential for 5HT1a resensitization. For instance: https:/...

We all have fluctuation of our level of energy and of our symptoms of PSSD and I think sometimes for no reason it's worst for fews weeks sometimes there's a nocebo effect and then we attribue the worsening to a crash from the currently substance. I think this is why almost all substances have been '...

Berberine is also 5a-inhibitor...
But I also think I crashed from Rodhiola Rosea and worsened. I was like 4 months after the beginning of PSSD so hard to say if it was the desease by itself or the Rodhiola...

1) I'm from France! 2)I couldn't recommend you advice but for me o would start with little dose of mushroom first (like 1g) wait for the effect and maybe try MDMA after 45min when the effect of mushroom is there. I think it's better to start like this because in my experience mushrooms are more unpr...

To be more clear what i wanted to say (sorry i'm not a good english speaker) the 5HTR2A are maybe more a 'side effect' of the mushrooms than the cure itself (that could be other thing) and maybe that's why severals people didn't benefit anything from psylo alone or from MDMA alone but one guy did fr...

Actually i was thinking trying Psylo and MDMA like a guy did and recovered from it. Psylocibin upregulate 5HT2A but only 24 or 48h hours later, before there's internalysation of the receptor. Psylo also work with 5HTRA1 and probably with many other stuff like methylation, AMPA and so. The thing is t...

Curcumin is hypomethylator as ECGC but unfortunately they don't really the major part of us... I'm still thinking of demethylator I will try soon astaxanthine which have hypomethylator properties but also 5AInh so maybe mix it with creatine or Cistanche. I'll let you know...

Hi guys, ‏I've posted a post that did not receive any comments. I'm suferring from PSSD for abaout 7 years. saw any doctor possible in my country, no one know this disorder or believe that it's even exist. the last doctor suggested this treatment- zinc supplement, testosterone injection (my levels ...

Hi everyone.
I also have the feeling I get a push a libido when i take spirulina but unfortunately it doesn't last... Like works a little week then back to baseline.

Don't worry things are gonna improve slowly but for sure. Try to keep in mind you're not alone and you can keep hope there's lot a research in progress