trazodone and brupropion combo are a suggested combo for low female libido disorder, HSDD. https://en.wikipedia.org/wiki/Bupropion ... ysfunction

"This notably includes the Pet-1 transcription factor that plays a critical role in the speciation, development and regulation of the serotonergic system (Hendricks et al., 1999; Goridis and Rohrer, 2002). A Pet-1 binding site is located upstream of the SERT encoding gene and Pet-1 binding was ...

The question is how do you increase WNT signalling and suppress mir-16? Dont you mean an upregulation of mir-16? in the locus ceruleus Most importantly you want to inhibit mir-16 in the dorsal raphe. Coincidentally, the dorsal raphe is part of the brain where 5ht1a pre-synaptic receptors are most a...

https://www.hindawi.com/journals/neuros ... 13/201909/
Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

Theoretically, it depends on the receptor. 5ht1a antagonists upregulate receptors over time but 5ht2a antagonists don't. However, pssd I believe is caused by permeant sert loss, so 5ht1a antagonism wouldn't upregulate receptors, but instead exacerbate the issue by blocking the little 5ht1a receptor...

I know blocking/antagonizing dopamine receptors causes upregulatation. And agonizing dopamine receptors causes down regulation -What does agonizing Serotonin receptors do long term to Serotonin receptors? -What does antagonizing Serotonin receptors do to the Serotonin receptors long term? Please ha...

sertraline is a sigma antagonist, i assume that's how he got cured. I tried half a pill a short time ago and I was feeling closer to normal and my cognition got better. Although, I didn't continue taking it because i was scared of the strange feeling i felt on my finger. Why do you think that a sig...

I know blocking/antagonizing dopamine receptors causes upregulatation. And agonizing dopamine receptors causes down regulation -What does agonizing Serotonin receptors do long term to Serotonin receptors? -What does antagonizing Serotonin receptors do to the Serotonin receptors long term? Please hav...

JakeLawe wrote: ↑Mon Dec 27, 2021 10:50 pm It still doesn't explain why the immune system would keep fighting something long gone.

because its not gone...lots of infections hide out in the intestine, bone barrow, cartilage, brain...places tough for the immune system to get to, just like with lyme disease

Just going to point out that buspirone/Buspar is a dopamine antagonist at the d2,d3, d4 receptors. So blocking dopamine receptors, upregulates them (more pro sexual dopamine), after you stop the Buspar. Buspar is also a "potent" 5ht1a receptor agonist, and people on the forums here claim h...