Search found 170 matches

by guacamo
Thu Feb 09, 2023 4:18 pm
Forum: General
Topic: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy
Replies: 18
Views: 15449

Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Can anyone make tl;dr of his PDF? I have problems with the download. I do admit that i did not look into PDF itself and I am largery sceptical to the simplified etiology outlined in the post, while recognizing that what it provides is only limited summarization of the whole concept. It doesn't mean ...
by guacamo
Tue Feb 07, 2023 3:33 am
Forum: Speculations and hypotheses
Topic: Does the post-SSRI syndrome affect previous psychological disorders?
Replies: 6
Views: 9236

Re: Does the post-SSRI syndrome affect previous psychological disorders?

There is circumstancial evidence that PSSD affect ion channel functions in a way that there is something wrong with extracellular/intracellular ions like magnesium, potassium, calcium. Perhaps increased oxidation also. Since work of every cell is hugely dependent on these ions, it is fair to assume ...
by guacamo
Sat Jan 21, 2023 2:05 am
Forum: Treatments and experimentation
Topic: Blood Results Show Elevated Liver Enzymes and TSH
Replies: 4
Views: 976

Re: Blood Results Show Elevated Liver Enzymes and TSH

Every single person suffers some form of health issue, if you check your health then you may find that there are some things not working properly. High TSH=hypothyroidism, which is very prevalent issue, it is estimated that around 10%~ of population has underactive thyroid. One of the reasons of you...
by guacamo
Fri Jan 20, 2023 8:51 am
Forum: Treatments and experimentation
Topic: Everything we knew about PSSD is wrong. Check out why.
Replies: 45
Views: 13642

Re: Everything we knew about PSSD is wrong. Check out why.

I do not threaten anyone, don't know where u got this assumption, I am just burned out and need a break. Thought that i will make faster progress on certain topics but it did not happen unfortunately. I understand your confusion on my post, but try to research those topics yourself which i basicall...
by guacamo
Fri Jan 20, 2023 8:05 am
Forum: General
Topic: can receptor desentization be seen in brain scan
Replies: 2
Views: 784

Re: can receptor desentization be seen in brain scan

It is possible but less selective than when taking sample, anyway if you mean checking out 5-ht1a receptor desensitization then there is much more things that influence certain receptor function than it's expression in the brain. There are studies that show reduction of 5-HT1A expression in midbrain...
by guacamo
Fri Jan 20, 2023 7:27 am
Forum: Treatments and experimentation
Topic: 5a-reductase inhibitor - good or bad?
Replies: 2
Views: 554

Re: 5a-reductase inhibitor - good or bad?

One of 5-a-reductase inhibitors named finasteride induces iatrogenic sexual dysfunction akin to PSSD, it's called "post-finasteride syndrome". Curcumin has complicated pharmacokinetics and pharmacology, i do not thing there is really analogy to finasteride when it comes to curcumin, but it...
by guacamo
Mon Jan 16, 2023 6:29 pm
Forum: General
Topic: PSSD Symptoms (Official Thread)
Replies: 453
Views: 169118

Re: PSSD Symptoms (Official Thread)

I do not know what he exactly mean but i assume something like this: After you take alcohol or benzodiazepines, which works on inhibitory neurotransmitter receptors called GABA (this induces relaxation from benzo and alcohol), after some time you experience withdrawals due to GABA levels and GABA re...
by guacamo
Mon Jan 16, 2023 5:57 pm
Forum: Treatments and experimentation
Topic: Everything we knew about PSSD is wrong. Check out why.
Replies: 45
Views: 13642

Re: Everything we knew about PSSD is wrong. Check out why.

I do not threaten anyone, don't know where u got this assumption, I am just burned out and need a break. Thought that i will make faster progress on certain topics but it did not happen unfortunately. I understand your confusion on my post, but try to research those topics yourself which i basically...
by guacamo
Mon Jan 16, 2023 2:17 pm
Forum: Treatments and experimentation
Topic: Everything we knew about PSSD is wrong. Check out why.
Replies: 45
Views: 13642

Re: Everything we knew about PSSD is wrong. Check out why.

I haven't figured things out to give any meaningful advice to the general population here still, will take a break from forum, do not plan to quit or anything but need refresh or change of scenery for a while. I can write to you general mechanics of PSSD of how i see this in huge TL:DR. In my opinio...
by guacamo
Wed Dec 28, 2022 1:26 pm
Forum: Treatments and experimentation
Topic: Everything we knew about PSSD is wrong. Check out why.
Replies: 45
Views: 13642

Re: Everything we knew about PSSD is wrong. Check out why.

Quick update from me. I had no free time available for a while and i also underestimated the necessary time for a proper research necessary for the update, but I am still going to do the update, just not yet, don't want to give exact date but perhaps middle to end of january. I know my methods work,...