I'm not sure but there's been a ton of reports of people crashing from benadryl

Hey yall, I got pssd from escitalopram and i tried to reverse it with trazodone, I had maybe 4 windows where it worked for like half an hour or so but then it didnt work anymore and i tapered off. Now i am two weeks on bupropion 150mg xl and i had very intensive windows already, much better than wi...

Any update on this? @Tree It's too early to tell. The only noticeable symptom is increased insomnia to the point I can't sleep at all. I'm extremely sensitive to anything that raises serotonin even at small doses. My approach with Curcumin is small doses a couple times a week to see if over time sy...

Niacin, inositol, and b6 all caused worsening symptoms for me. It's all serotonin related.

What do we suspect is the main mechanism behind Ginger crashing us? Is it the 5-HT1A Partial agonism? Loss of sert expression via epigenetic changes from ssri is what makes us susceptible to crashes by 5ht1a agonists. How can we remedy this? Look at the recent posts on my most active topic

Both Curcumin and Valproic acid increase wnt3a expression in the brain. I'm going to microdose Curcumin extract and see what happens. "In the hippocampus, curcumin enhanced the expression of Wnt3a, Dvl, FZD1 and LRP5/6, and the Wnt target genes Ngn2 and NeuroD1" "Here, we determined t...

"The authors found that fluoxetine infusion into the raphe increased the rate of miR-16 maturation from its precursor, which was blocked by WNT3A." https://www.nature.com/articles/nrn2941 This suggests WNT3A might block the mir16 directed effects on SERT. The only thing I have found to in...

fluvoxamine increases Akt-phosphorylation through sigma1-receptors [180,181], while sertraline decreases it [182]. Sertraline inhibition of Akt leads to more gsk3b expression which causes less canonical wnt activation and decrease sert expression through changes in microrna. It probably explains wh...

"Our findings indicate that GSK3B expression was upregulated by the continuous treatment with sertraline" "However, after 12 months of treatment we found a significant increase in the expression of total GSK3B" Lithium is used in many studies to mitigate induced gsk3b expression ...

"sigma is very overlooked in pssd fluoxetine and other SBSSs can directly alter serotonergic systems through Sigma receptors Sigma-1 controls SERT and 5HT2C Yet nobody mentions this receptor this is unbelievable Neurosteroids and Progesterone bind to sigma All PSSD patients have high Progester...