Here we see the chronic effects on the brain's serotonin system where the feedback 5-HT1A is internalized/desensitized and damaged by uncoupling from it's g-protein and losing part of it's function. But these recover after discontinuation, only the transporter SERT is actually degraded over time and...

Any experiences with vitamin A besides op? I'm curious to try because I believe sert dysfunction causes pssd. I experienced worsening symptoms from taking inositol. "13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitr...

Anyone else try lithium?

Just want to add that St. John's Wort made me extremely depressed and anxious and ruined my one vacation I'd had in years with my mom. It also made me crash some. Just warning that if you try it and feel bad at all, stop taking it immediately. It's kinda subtle and I thought I was just depressed be...

There is strong clinical evidence that R-citalopram inhibits the antidepressant effect of escitalopram (Kennedy et al. 2006; Lepola et al. 2004; Llorca et al. 2005). We here show that R-citalopram does not appear to directly affect the 5-HTExt-enhancing action of escitalopram at the hSERT, a key fin...

Interesting if you can reverse sert inhibition somehow I do believe people will get some relief

It has already been established that people who are on or near the autism spectrum are more vulnerable to getting PSSD, and, if afflicted by it, are less likely to be cured from it. I theorize that the suffering reaction that is caused by high acceleration is an autism-associated trait, that is pre...

Yes made symptoms worse

I'd stay clear of Naltrexone seems to decrease 5ht1a expression in several parts of the brain. Naltrexone desensitizes serotonin receptors to curb alcohol intake. This is also why most people with pssd no longer get effects from drugs or alcohol. Our receptors are desensitized from decreased sert ex...

They call it " inappropriate or excessive sexual urges " LOL ! So this is our problem : " By increasing levels of serotonin in the CNS, the SSRIs may tighten the brain’s built-in controls on erection " Now how to reset the serotonin levels in our CNS ? Any ideas ? Normalize sert...