Search found 281 matches
- Sat Dec 23, 2023 1:45 am
- Forum: Treatments and experimentation
- Topic: Spyros 100% cured by Estrogen + TRT
- Replies: 52
- Views: 67696
Re: Spyros 100% cured by Estrogen + TRT
I'm not cured, but I improved the worst symptoms of PSSD by taking Clomid. I no longer have insomnia or that extreme tiredness that didn't allow me to get out of bed. Instead of total anorgasmia, I can have weak orgasms now. I'm going to flood my body with massive doses of HCG. 1000 IU 3 times a we...
- Sun Dec 17, 2023 2:23 am
- Forum: Treatments and experimentation
- Topic: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
- Replies: 6
- Views: 12949
Re: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
Strange I have severe pssd with high folate blood levels and I'm super sensitive to b vitamins. I've tried inositol and niacin. Both worsen my extreme insomnia and tinnitus. Research also shows SSRIs methylate the serotonin transporter. Overmethylation symptoms are similar to PSSD symptoms too.
- Thu Nov 30, 2023 11:06 pm
- Forum: General
- Topic: I can probably help you improve your symptoms
- Replies: 22
- Views: 8145
Re: I can probably help you improve your symptoms
There seems to be some interaction with 5ht1a receptors so I'd be cautious.heymartinn wrote: ↑Thu Nov 30, 2023 9:19 amIs it though? All I can find is antagonism against several 5HT subtypes but no mention of 5HT1A agonism
https://pubmed.ncbi.nlm.nih.gov/29859012/
- Thu Nov 30, 2023 12:46 am
- Forum: General
- Topic: I can probably help you improve your symptoms
- Replies: 22
- Views: 8145
Re: I can probably help you improve your symptoms
I can’t remember for sure, but I’m almost positive I have. Of course you can try it without the naltrexone, but if it doesn’t give you significant improvements, you can always try the naltrexone. This is the only thing that worked for me in any permanent way, and it worked very quickly too. You cla...
- Wed Nov 29, 2023 9:49 pm
- Forum: General
- Topic: I can probably help you improve your symptoms
- Replies: 22
- Views: 8145
Re: I can probably help you improve your symptoms
Op have you tried the hoppy beer without Naltrexone? I'm very skeptical that Naltrexone can help pssd from the research I've done. Alcohol on the other hand can possibly reverse some of the structural epigenetic changes caused by SSRIs.
- Sun Oct 22, 2023 6:15 pm
- Forum: PSSD related research
- Topic: An Excellent Explaination of How SSRI's Inhibit Sert
- Replies: 85
- Views: 87412
Re: An Excellent Explaination of How SSRI's Inhibit Sert
"Individuals receiving citalopram only showed an increase in the expression of mir-16 while administration of sertraline led to a significant increase in the expression of mir-16 and a decrease in mir-124 and mir-132 (P<0.05)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311976/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311976/
- Mon Oct 09, 2023 6:18 am
- Forum: PSSD related research
- Topic: An Excellent Explaination of How SSRI's Inhibit Sert
- Replies: 85
- Views: 87412
Re: An Excellent Explaination of How SSRI's Inhibit Sert
"Fluoxetine suppressed a LiCl-induced increase of total β-catenin and a LiCl-induced decrease of phosphorylated β-catenin in a dose-dependent manner" "fluoxetine enhanced binding of β-catenin with Axin1, which is a scaffold protein forming the degradation complex for β-catenin." ...
- Tue Aug 29, 2023 6:43 am
- Forum: General
- Topic: Do you also suffer from hypersomnia?
- Replies: 4
- Views: 5984
Re: Do you also suffer from hypersomnia?
Sertraline gave me extreme insomnia too I have no tired sensation anymore and wake up not feeling rested
- Sat Aug 26, 2023 5:31 pm
- Forum: General
- Topic: Please AVOID doing weed/cannabis/THC
- Replies: 16
- Views: 16540
Re: Please AVOID doing weed/cannabis/THC
Weed will only make condition worse with chronic use because it increases serotonin and agonizes 5ht1a receptors. 5ht1a agonism along with elevated serotonin desensitizes receptors which causes pssd symptoms to worsen.
- Sat Jul 22, 2023 11:50 pm
- Forum: PSSD related research
- Topic: An Excellent Explaination of How SSRI's Inhibit Sert
- Replies: 85
- Views: 87412
Re: An Excellent Explaination of How SSRI's Inhibit Sert
The up-regulation of miR-16 and the down-regulation of pre/pri–miR-16 triggered by fluoxetine in raphe were both eliminated by either Wnt3a, LiCl, or SB-216763
https://www.science.org/doi/10.1126/science.1193692
https://www.science.org/doi/10.1126/science.1193692