Search found 281 matches

by Tree
Sat Dec 23, 2023 1:45 am
Forum: Treatments and experimentation
Topic: Spyros 100% cured by Estrogen + TRT
Replies: 52
Views: 67696

Re: Spyros 100% cured by Estrogen + TRT

I'm not cured, but I improved the worst symptoms of PSSD by taking Clomid. I no longer have insomnia or that extreme tiredness that didn't allow me to get out of bed. Instead of total anorgasmia, I can have weak orgasms now. I'm going to flood my body with massive doses of HCG. 1000 IU 3 times a we...
by Tree
Sun Dec 17, 2023 2:23 am
Forum: Treatments and experimentation
Topic: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
Replies: 6
Views: 12949

Re: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes

Strange I have severe pssd with high folate blood levels and I'm super sensitive to b vitamins. I've tried inositol and niacin. Both worsen my extreme insomnia and tinnitus. Research also shows SSRIs methylate the serotonin transporter. Overmethylation symptoms are similar to PSSD symptoms too.
by Tree
Thu Nov 30, 2023 11:06 pm
Forum: General
Topic: I can probably help you improve your symptoms
Replies: 22
Views: 8145

Re: I can probably help you improve your symptoms

heymartinn wrote: Thu Nov 30, 2023 9:19 am
Tree wrote: Thu Nov 30, 2023 12:46 am Naltrexone is a 5-HT1A agonist
Is it though? All I can find is antagonism against several 5HT subtypes but no mention of 5HT1A agonism
There seems to be some interaction with 5ht1a receptors so I'd be cautious.

https://pubmed.ncbi.nlm.nih.gov/29859012/
by Tree
Thu Nov 30, 2023 12:46 am
Forum: General
Topic: I can probably help you improve your symptoms
Replies: 22
Views: 8145

Re: I can probably help you improve your symptoms

I can’t remember for sure, but I’m almost positive I have. Of course you can try it without the naltrexone, but if it doesn’t give you significant improvements, you can always try the naltrexone. This is the only thing that worked for me in any permanent way, and it worked very quickly too. You cla...
by Tree
Wed Nov 29, 2023 9:49 pm
Forum: General
Topic: I can probably help you improve your symptoms
Replies: 22
Views: 8145

Re: I can probably help you improve your symptoms

Op have you tried the hoppy beer without Naltrexone? I'm very skeptical that Naltrexone can help pssd from the research I've done. Alcohol on the other hand can possibly reverse some of the structural epigenetic changes caused by SSRIs.
by Tree
Sun Oct 22, 2023 6:15 pm
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 85
Views: 87412

Re: An Excellent Explaination of How SSRI's Inhibit Sert

"Individuals receiving citalopram only showed an increase in the expression of mir-16 while administration of sertraline led to a significant increase in the expression of mir-16 and a decrease in mir-124 and mir-132 (P<0.05)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311976/
by Tree
Mon Oct 09, 2023 6:18 am
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 85
Views: 87412

Re: An Excellent Explaination of How SSRI's Inhibit Sert

"Fluoxetine suppressed a LiCl-induced increase of total β-catenin and a LiCl-induced decrease of phosphorylated β-catenin in a dose-dependent manner" "fluoxetine enhanced binding of β-catenin with Axin1, which is a scaffold protein forming the degradation complex for β-catenin." ...
by Tree
Tue Aug 29, 2023 6:43 am
Forum: General
Topic: Do you also suffer from hypersomnia?
Replies: 4
Views: 5984

Re: Do you also suffer from hypersomnia?

Sertraline gave me extreme insomnia too I have no tired sensation anymore and wake up not feeling rested
by Tree
Sat Aug 26, 2023 5:31 pm
Forum: General
Topic: Please AVOID doing weed/cannabis/THC
Replies: 16
Views: 16540

Re: Please AVOID doing weed/cannabis/THC

Weed will only make condition worse with chronic use because it increases serotonin and agonizes 5ht1a receptors. 5ht1a agonism along with elevated serotonin desensitizes receptors which causes pssd symptoms to worsen.
by Tree
Sat Jul 22, 2023 11:50 pm
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 85
Views: 87412

Re: An Excellent Explaination of How SSRI's Inhibit Sert

The up-regulation of miR-16 and the down-regulation of pre/pri–miR-16 triggered by fluoxetine in raphe were both eliminated by either Wnt3a, LiCl, or SB-216763

https://www.science.org/doi/10.1126/science.1193692