I emailed the authors of the ABCB1 paper to see if they can provide it open access for us.

Regarding lithium, this study shows it interacts with GR and HPA axis:

https://journals.plos.org/plosone/artic ... ne.0027613

Also, I have two minor alleles in the NR3C1 gene, which encodes GR. The SNPs are rs7701443 and rs12521436. I havent done a 24h cortisol test, but on a morning fasted blood test I showed low cortisol. I tend to take a while to feel fully awake in the mornings, so I suspect I have a weak cortisol awak...

If you want to try directly agonizing or antagonizing cortisol receptors (which could cause a feedback loop to change cortisol levels), you can try mifepristone (antagonist) or dexamethasone (agonist).

We know androgen receptors (AR) are of importance to sexual function. For instance, Androgen Deprivation Therapy used to treat prostate cancer in young men can cause sexual dysfunction similar in many ways to PSSD [1]. Additionally, finasteride has been shown to upregulate AR [2,3]. But what about g...

Bunny, did you make any dietary changes during your healing period, or have you maintained a mostly similar diet this whole time?

Very exciting, we are all appreciative of your efforts. This is some excellent citizen science work. This is the kind of stuff that could one day end up as a front page story in the NY Times.

Thanks for trying something. Please let us know how it goes, good luck!

Guys, there is no point in being negative. You are only making your life worse than it already is. The best thing to do, is to simply believe we WILL find a cure SOON, as long as YOU (the reader) help the community. No one knows for certain whether a cure will be found. But rather than wallow in the...

Different forums have different moderation styles, I like the diversity. As long as everyone in the community shares information between forums, it's fine. For instance HackStasis tends to be somewhat chaotic and fast-moving, while this forum is slower but with less low-quality posts.