desensitization 5ht1a

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guacamo
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Re: desensitization 5ht1a

Unread post by guacamo »

https://imgur.com/oTnp0s6
Here is the distribution of 5-HT1A receptor in the human brain. This receptor is both pro sexual and antisexual depending on where you activate it, since drugs are mostly non-selective in what pathway they do stimulate, it is hard to predict both short-term and long-term effects of the supplementation.
highman
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Re: desensitization 5ht1a

Unread post by highman »

Berberine 5ht1a inhibition is reversible?
Tree
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Re: desensitization 5ht1a

Unread post by Tree »

highman wrote: Sat Jul 24, 2021 5:18 pm Berberine 5ht1a inhibition is reversible?
Possibly, depends how severe the crash was.
Thomas
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Re: desensitization 5ht1a

Unread post by Thomas »

I am not a big fan neither of "simple" theories such as "it's all due to this receptor" nor of animal studies, but I am surprised nobody mentioned ginkgo biloba here, although there are lots of animal studies showing its potential for 5HT1a resensitization.
For instance:
https://pubmed.ncbi.nlm.nih.gov/7628830/
https://pubmed.ncbi.nlm.nih.gov/8051617/
https://www.sciencedirect.com/science/a ... 8418311089
https://link.springer.com/article/10.10 ... 21-02281-5

For those who are convinced it's 5ht1a desensitization, GBe could be an good trial.

I had a good (everything was back) but short (one week) window on ginkgo. I stopped after the window but improvements on my sleep have remained, so I guess this wasn't only placebo.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | anhedonia | insomnia
Janie
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Re: desensitization 5ht1a

Unread post by Janie »

Could you link which brand was used and which dosage?
Thomas
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Re: desensitization 5ht1a

Unread post by Thomas »

It was a French brand, Nutrisanté, 200mg/day of GBe
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | anhedonia | insomnia
Impermanence
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Re: desensitization 5ht1a

Unread post by Impermanence »

Thomas wrote: Fri Aug 06, 2021 4:48 am I am not a big fan neither of "simple" theories such as "it's all due to this receptor" nor of animal studies, but I am surprised nobody mentioned ginkgo biloba here, although there are lots of animal studies showing its potential for 5HT1a resensitization.
For instance:
https://pubmed.ncbi.nlm.nih.gov/7628830/
https://pubmed.ncbi.nlm.nih.gov/8051617/
https://www.sciencedirect.com/science/a ... 8418311089
https://link.springer.com/article/10.10 ... 21-02281-5

For those who are convinced it's 5ht1a desensitization, GBe could be an good trial.

I had a good (everything was back) but short (one week) window on ginkgo. I stopped after the window but improvements on my sleep have remained, so I guess this wasn't only placebo.
I used many times GB with little effect but after I read your post I read again the bibliography about GB and that true I took 120mg extract 50:1 and in most study they used 240 to 360 a day. I still have some at home, will try higher doses, doesn't seem very harmful.
Thomas
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Re: desensitization 5ht1a

Unread post by Thomas »

Impermanence wrote: Sat Aug 07, 2021 5:02 am I still have some at home, will try higher doses, doesn't seem very harmful.
Ginkgo biloba has been listed here as harmful: https://www.pssdforum.org/viewtopic.php?p=39245#p39245
I would avoid 5ar-inhibitor but I haven't found anything proving that GBe is one - and this post lists so many things (vitamin D!?) without any reference...
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | anhedonia | insomnia
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