PSSD MEDICAL LITERATURE

[anacleta]

1) Persistent Sexual Side Effects after SSRI Discontinuation, Antonei B. Csoka, Stuart Shipko, 2006
http://www.ncbi.nlm.nih.gov/pubmed/16636635
http://www.karger.com/Article/FullText/91777

2) Genital anaesthesia persisting six years after sertraline discontinuation, Bolton JM, Sareen J, Reiss JP, 2006
http://www.ncbi.nlm.nih.gov/pubmed/16709553
http://www.tandfonline.com/doi/full/10. ... CwQwBbWZbU

3) Post SSRI Sexual Dysfunction, Audrey Bahrick, 2006
http://www.researchgate.net/publication ... ysfunction

4) Prolonged Post-Treatment Genital Anesthesia and Sexual Dysfunction Following Discontinuation of Citalopram and the Atypical Antidepressant Nefazodone, Robert P. Kauffman, Amanda Murdock, 2007
http://www.benthamscience.com/open/towh ... 1TOWHJ.pdf
http://benthamopen.com/towhj/articles/V001/1TOWHJ.pdf

5) Persistent Sexual Dysfunction after Discontinuation of Selective Serotonin Reuptake Inhibitors, Antonei Csoka, Audrey Bahrick, Olli-Pekka Mehtonen, 2008
http://www.ncbi.nlm.nih.gov/pubmed/18173768
http://www.researchgate.net/publication ... inhibitors
http://psychrights.org/Research/Digest/ ... 007%29.pdf

6) Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence, Audrey S. Bahrick, 2008
http://www.researchgate.net/publication ... g_evidence
http://psychrights.org/research/Digest/ ... ffects.pdf

7) Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap, Audrey S. Bahrick, Mark M. Harris, 2008 https://link.springer.com/article/10.10 ... 008-9094-0

8) Persistent Genital Arousal Disorder in Women: Case Reports of Association with Anti-Depressant Usage and Withdrawal, Sandra R. Leibluma & David Goldmeierb, 2008
http://www.ncbi.nlm.nih.gov/pubmed/18224549
http://www.tandfonline.com/doi/full/10. ... 0701636205

9) Persistent sexual dysfunction in genitourinary medicine clinic attendees induced by selective serotonin reuptake inhibitors, Farnsworth KD, Dinsmore WW, 2009
http://www.ncbi.nlm.nih.gov/pubmed/19103903
http://www.mediafire.com/view/2ing236fw ... sworth.pdf

10) Does sexual dysfunction persist upon discontinuation of selective serotonin reuptake inhibitors?, G.C. Ekhart, E.P. van Puijenbroek, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24838589
http://www.lareb.nl/LarebCorporateWebsi ... 3_SSRI.pdf

11) One hundred and twenty cases of enduring sexual dysfunction following treatment, Hogan C, Le Noury J, Healy D, Mangin D, 2014
http://www.ncbi.nlm.nih.gov/pubmed/24902508
http://davidhealy.org/wp-content/upload ... d-PSSD.pdf

12) Penile anesthesia in post SSRI sexual dysfunction (PSSD) responds to low-power laser irradiation: A case study and hypothesis about the role of transient receptor potential (TRP) ion channels, Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J, 2014
http://www.ncbi.nlm.nih.gov/pubmed/25483212
http://www.sciencedirect.com/science/ar ... 9914008462

13) Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship. Ben-Sheetrit J, Aizenberg D, Csoka AB, Weizman A, Hermesh H., 2015
http://www.ncbi.nlm.nih.gov/pubmed/25815755

14) Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies. Simonsen AL, Danborg PB, Gøtzsche PC. 2016
https://www.ncbi.nlm.nih.gov/pubmed/27176752

15) Sexual Consequences of Post-SSRI Syndrome. Reisman Y1, 2017
https://www.ncbi.nlm.nih.gov/pubmed/28642048

16) Post-serotonine selective reuptake inhibitors persistent sexual dysfunction after serotonine selective reuptake inhibitors treatment: A case report after stopping paroxetine. Omar Walid Muquebil Ali Al Shaban Rodrígueza, Enrique Álvarez de Morales Gómez-Morenob, Jennifer Fernández Fernándeza, Carmen Fresno Garcíac, María del Mar Fernández Fernández, 2017
https://www.researchgate.net/publicatio ... paroxetina

17) Post-SSRI Sexual Dysfunction: A Literature Review. Bala A, Tue Nguyen HM, Hellstrom WJG, 2017
https://www.ncbi.nlm.nih.gov/pubmed/28778697

18) Post-SSRI Sexual Dysfunction: Preclinical to Clinical. Is It Fact or Fiction? E. R. Coskuner, M. G. Culha, B. Ozkan, E. O. Kaleagasi, 2018
https://www.ncbi.nlm.nih.gov/pubmed/29463440

19) Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin? Giatti S, Diviccaro S, Panzica G, Melcangi RC, 2018
https://www.ncbi.nlm.nih.gov/pubmed/29675596

20) Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases. Healy D, Le Noury J, Mangin D, 2018
https://www.ncbi.nlm.nih.gov/pubmed/29733030

21) Citizen petition: Sexual side effects of SSRIs and SNRIs. Healy D, 2018
https://www.ncbi.nlm.nih.gov/pubmed/29733031

22) The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells. Kanherkar RR, Getachew B, Ben-Sheetrit J, Varma S, Heinbockel T, Tizabi Y, Csoka AB, 2018
https://www.ncbi.nlm.nih.gov/pubmed/30148158

23) Towards improving post-SSRI sexual dysfunction by using nutriceuticals: Lessons from a case study. Salvatore Calabrò R, De Luca R, Manuli A, Portaro S, Naro A, Quattrini F, 2019
https://www.ncbi.nlm.nih.gov/pubmed/30640584

24) Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals. Healy D, Le Noury J, Mangin D, 2019
https://www.ncbi.nlm.nih.gov/pubmed/31450514
https://rxisk.org/wp-content/uploads/20 ... script.pdf

25) Persistent adverse effects of antidepressants. Moncrieff J, 2019
https://www.ncbi.nlm.nih.gov/pubmed/31543093

26) Post-SSRI sexual dysfunction & other enduring sexual dysfunctions. Healy D, 2019
https://www.ncbi.nlm.nih.gov/pubmed/31543091

27) Clinical judgments, not algorithms, are key to patient safety—an essay by David Healy and Dee Mangin. Healy D, Dee Mangin, 2019
https://www.bmj.com/content/367/bmj.l5777

[PZS1234]

Is this the ultimate/complete list we should be bringing to our doctors?

Thank you,

PZS

[Micromegas]

Great job collecting these into one list.

[north4]

very good

[Wozzi7]

Thanks for collecting these. For those who need to convince a doctor that PSSD is indeed a real problem, literature helps.

[anacleta]

new study !!!!

http://www.ncbi.nlm.nih.gov/pubmed/25815755

J Clin Psychopharmacol. 2015 Mar 26. [Epub ahead of print]

Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship.

Ben-Sheetrit J, Aizenberg D, Csoka AB, Weizman A, Hermesh H.

Abstract

Emerging evidence suggests that sexual dysfunction emerging during treatment with selective serotonin reuptake inhibitors (SSRIs) and/or serotonin-norepinephrine reuptake inhibitors (SNRIs) persists in some patients beyond drug discontinuation (post-SSRI sexual dysfunction [PSSD]). We sought to identify and characterize a series of such cases and explore possible explanatory factors and exposure-response relationship. Subjects who responded to an invitation in a forum dedicated to PSSD filled out a survey via online software. Case probability was defined according to the following 3 categories of increasing presumed likelihood of PSSD. Noncases did not meet the criteria for possible cases. Possible cases were subjects with normal pretreatment sexual function who first experienced sexual disturbances while using a single SSRI/SNRI, which did not resolve upon drug discontinuation for 1 month or longer as indicated by Arizona Sexual Experience Scale scores. High-probability cases were also younger than 50-year-olds; did not have confounding medical conditions, medications, or drug use; and had normal scores on the Hospital Anxiety and Depression Scale. Five hundred thirty-two (532) subjects completed the survey, among which 183 possible cases were identified, including 23 high-probability cases. Female sex, genital anesthesia, and depression predicted current sexual dysfunction severity, but dose/defined daily dose ratio and anxiety did not. Genital anesthesia did not correlate with depression or anxiety, but pleasureless orgasm was an independent predictor of both depression and case probability. Limitations of the study include retrospective design and selection and report biases that do not allow generalization or estimation of incidence. However, our findings add to previous reports and support the existence of PSSD, which may not be fully explained by alternative nonpharmacological factors related to sexual dysfunction, including depression and anxiety.

[Maldoror]

This one is great! It's the second study now that specifically mentions the acronym "PSSD". which is great for awareness.

[future-recovery]

Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap, Bahrick A, Harris MM, 2009
https://www.researchgate.net/publicatio ... bility_Gap

Psychiatric disorders and sexual dysfunction. Waldinger MD, 2015
Abstract (full text contains more text about PSSD and SSRI-induced PGAD)
http://www.ncbi.nlm.nih.gov/pubmed/26003261

[future-recovery]

*Waldinger MD
Pharmacotherapy for premature ejaculation. (2015)
Abstract (only the full text contains information about PSSD and SSRI-induced PGAD):
http://www.ncbi.nlm.nih.gov/pubmed/26579971


*Rxisk
Post-SSRI Sexual Dysfunction (PSSD) (2016)

2016 Medically reviewed by RxISK’s Medical Team.

http://rxisk.org/post-ssri-sexual-dysfunction-pssd/

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Just for completeness some medical books (at least I assume these are medical books or psychotherapy textbooks) that have written only 1-2 sentences about PSSD (basically they just mention the existence of case reports or that the sexual dysfunction can persist):

(a dictionary of medicine lists the term Post-SSRI Sexual Dysfunction)
*Harris P, Nagy S, Vardaxis N
Mosby's Dictionary of Medicine, Nursing and Health Professions (2014)
page 1386
https://books.google.com/books?id=_itVC ... kQ6AEIJTAB

A book for dentists mentions PSSD:
James W Little et al.
Dental Management of the Medically Compromised Patient 2012, chapter Psychiatric Disorders, page 552
https://www.elsevier.com/books/little-a ... 23-08028-6

Joseph Goldberg, Carrie Ernst
Managing the Side Effects of Psychotropic Medications 2012
Page 229
https://www.appi.org/managing_the_side_ ... edications

Jill Littrell
Neuroscience for Psychologists and Other Mental Health Professionals 2015
Page 158
http://www.springerpub.com/neuroscience ... onals.html

Marc Goldstein, Peter N. Schlegel
Surgical and Medical Management of Male Infertility 2013
Page 213
http://www.cambridge.org/catalogue/cata ... 0521881098

Aniyizhai Annamalai
Medical Management of Psychotropic Side Effects (2017)
Page 130
http://www.springer.com/gp/book/9783319510248

Zoe D. Peterson
The Wiley-Blackwell Handbook of Sex Therapy (2017)
Page 205
http://eu.wiley.com/WileyCDA/WileyTitle ... 10372.html

Kathleen Tusaie, Joyce Fitzpatrick
Advanced Practice Psychiatric Nursing, Second Edition: Integrating Psychotherapy, Psychopharmacology, and Complementary and Alternative Approaches Across the Life Span (2016)
Page 65
http://www.springerpub.com/advanced-pra ... ition.html

[future-recovery]

Waldinger's PSSD article is now in the "Textbook of Clinical Sexual Medicine" (2017) from Waguih William Ishak.

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Premature ejaculation case report from 2003:
https://www.researchgate.net/publicatio ... Withdrawal

Polish premature ejaculation case report from 2011
https://www.researchgate.net/publicatio ... ase_report