"Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

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anacleta
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"Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

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https://www.liebertpub.com/doi/abs/10.1 ... lCode=bioe

Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?

David Healy, Joshua LaPalme, and Michael Levin

Published Online:12 Dec 2019 https://doi.org/10.1089/bioe.2019.0010

Abstract
Selective serotonin reuptake inhibitor (SSRI) drugs, targeting serotonin transport, are widely used. A puzzling and biomedically important phenomenon concerns the persistent sexual dysfunction following SSRI use seen in some patients. What could be the mechanism of a persistent physiological state brought on by a transient exposure to serotonin transport blockers? In this study, we briefly review the clinical facts concerning this side effect of serotonin reuptake inhibitors and suggest a possible mechanism. Bioelectric circuits (among neural or non-neural cells) could persistently maintain alterations of bioelectric cell properties (resting potential), resulting in long-term changes in electrophysiology and signaling. We present new data revealing this phenomenon in planarian flatworms, in which brief SSRI exposures induce long-lasting changes in resting potential profile. We also briefly review recent data linking neurotransmitter signaling to developmental bioelectrics. Further study of tissue bioelectric memory could enable the design of ionoceutical interventions to counteract side effects of SSRIs and similar drugs
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Re: "Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

Unread post by squirtleSquirtle »

Thank's for posting! Somehow this didn't come up on google scholar in my review of the literature this weekend. Could be because it's hot off the press.

Look's like a good paper.
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anacleta
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Re: "Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

Unread post by anacleta »

translated from Italian page: https://it.wikipedia.org/wiki/Segnale_bioelettrico
The bioelectric signal is the signal that flows in the nerves given by a chain of shifts of potassium (K +) and sodium (Na +) cations from the outside to the inside of the cell membrane of the neuron and vice versa.

In fact, in the rest situation (ie without having received a stimulus, be it excitatory or inhibitory), the neuron reaches stability with a potential difference between the inside and the outside of the cell membrane of -70mV (millivolts), said resting potential. This exists given the different ratio of charged particles between inside the membrane and outside. On the outside, the Na + ion is kept in quantities 10 times higher than the inside and every 30 K + ions in the intracellular fluid there is 1 in the extracellular fluid. The membrane is in fact maintained, by special pumps, 50 times more permeable to potassium than to sodium. But when the membrane undergoes an adequate stimulus, the threshold stimulus becomes 500 times more permeable to sodium than to potassium in the stimulated area. A more intense stimulus does not produce a greater reaction and a less intense one produces no reaction. Sodium ions, attracted by internal charges (-70mV) cross, now easily, the membrane in the stimulated area. The flow, towards the cytoplasm of the neuron of the Na + ions, reaches an apex and while it is diminishing, that of the K + ions in the opposite direction begins. Then the situation in that area of ​​the neuron returns to normal when the pump returns to function. These processes constitute a short-term modification called pulse or bioelectric signal. However, this impulse does not stop only at the stimulated zone, in fact the transit of charges essentially creates another stimulus for another zone of the membrane in which the pump that was in operation modifies its behavior. The passage of charges through the membrane causes a potential difference of + 30mV between the inside and the outside to be reached, at the apex: defined action potential.
looks very interesting this topic

let's wait full text of the study
arahant
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Re: "Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

Unread post by arahant »

anacleta wrote:https://www.liebertpub.com/doi/abs/10.1 ... lCode=bioe

Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?

David Healy, Joshua LaPalme, and Michael Levin

Published Online:12 Dec 2019 https://doi.org/10.1089/bioe.2019.0010

Abstract
Selective serotonin reuptake inhibitor (SSRI) drugs, targeting serotonin transport, are widely used. A puzzling and biomedically important phenomenon concerns the persistent sexual dysfunction following SSRI use seen in some patients. What could be the mechanism of a persistent physiological state brought on by a transient exposure to serotonin transport blockers? In this study, we briefly review the clinical facts concerning this side effect of serotonin reuptake inhibitors and suggest a possible mechanism. Bioelectric circuits (among neural or non-neural cells) could persistently maintain alterations of bioelectric cell properties (resting potential), resulting in long-term changes in electrophysiology and signaling. We present new data revealing this phenomenon in planarian flatworms, in which brief SSRI exposures induce long-lasting changes in resting potential profile. We also briefly review recent data linking neurotransmitter signaling to developmental bioelectrics. Further study of tissue bioelectric memory could enable the design of ionoceutical interventions to counteract side effects of SSRIs and similar drugs
I had access to the full text.

It seems to be a promising research area.
In summary, it shows that SSRI changes several ion channels, mainly the resting potential (Vmem).

It tests this hypothesis on an animal model (Planaria husbandry) using Fluoxetine.
It shows that differences in Vmem persist after a week of drug withdrawal.

But:

"Bioelectric memory has not yet been demonstrated in human patient tissues, representing an important area for subsequent work, which could be addressed in vivo and in human organoid systems in vitro"

Tang-Schomer MD, White JD, Tien LW, et al. Bioengineered functional brain-like cortical tissue. Proc Natl Acad Sci U S A 2014;111:13811–13816. Crossref, Medline, Google Scholar


And it proposes another approach to deal with persistent SSRI symptoms like genital anesthesia.

Instead of fix the brain serotonin system, something that may not work, and the paper cites the example of tardive effects of antipsychotics:

"This is similar to research efforts on tardive dyskinesia which for four decades have focused on the dopamine system without finding an answer."

And proposes:

"it's possible that the negative effects of SSRI exposure could someday be mitigated by rationally designed cocktails of already human-approved drugs acting as ionoceuticals"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308252/
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anacleta
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Re: "Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

Unread post by anacleta »

for the full text
go here http://scihub.bban.top/
and past this: doi.org/10.1089/bioe.2019.0010
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Re: "Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?" D. Healy 2019

Unread post by kpavel »

BUMP for sure, nothing is infinite under the Moon/the Sun, even pssd.
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