Ideas of what's involved with not getting boozed

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Semogomes
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Ideas of what's involved with not getting boozed

Unread post by Semogomes »

What is behind not getting the high of alcohol or even coffee anymore? Even the ease of nicotine I can't get anymore

This shit scares me af. And anyone here have this or had this after pssd and recovered?
Northern_Star
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Re: Ideas of what's involved with not getting boozed

Unread post by Northern_Star »

The buzz from alcohol is associated with an increase in allopregnanolone levels (e.g. https://pubmed.ncbi.nlm.nih.gov/12700685/).

"PFS" patients also report that they do not get the buzz from alcohol anymore. An assessment of levels of neuroactive steroids in "PFS" patients showed dramatically lower allopregnanolone levels compared to controls (https://pubmed.ncbi.nlm.nih.gov/28408350/). The whole causative chain in the generation of neurosteroids is subject to proper androgenic signaling, which we know is dysregulated in "PFS" patients. It is increasingly obvious that the same is properly true for "PSSD".
Semogomes
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Re: Ideas of what's involved with not getting boozed

Unread post by Semogomes »

Northern_Star wrote: Fri Sep 04, 2020 8:08 am The buzz from alcohol is associated with an increase in allopregnanolone levels (e.g. https://pubmed.ncbi.nlm.nih.gov/12700685/).

"PFS" patients also report that they do not get the buzz from alcohol anymore. An assessment of levels of neuroactive steroids in "PFS" patients showed dramatically lower allopregnanolone levels compared to controls (https://pubmed.ncbi.nlm.nih.gov/28408350/). The whole causative chain in the generation of neurosteroids is subject to proper androgenic signaling, which we know is dysregulated in "PFS" patients. It is increasingly obvious that the same is properly true for "PSSD".
Any idea of how can I overcome this?
Semogomes
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Re: Ideas of what's involved with not getting boozed

Unread post by Semogomes »

Semogomes wrote: Fri Sep 04, 2020 8:20 am
Northern_Star wrote: Fri Sep 04, 2020 8:08 am The buzz from alcohol is associated with an increase in allopregnanolone levels (e.g. https://pubmed.ncbi.nlm.nih.gov/12700685/).

"PFS" patients also report that they do not get the buzz from alcohol anymore. An assessment of levels of neuroactive steroids in "PFS" patients showed dramatically lower allopregnanolone levels compared to controls (https://pubmed.ncbi.nlm.nih.gov/28408350/). The whole causative chain in the generation of neurosteroids is subject to proper androgenic signaling, which we know is dysregulated in "PFS" patients. It is increasingly obvious that the same is properly true for "PSSD".
Any idea of how can I overcome this? I have several symptoms of androgen mess
Northern_Star
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Re: Ideas of what's involved with not getting boozed

Unread post by Northern_Star »

There is no way to overcome this currently. First, we need to understand this condition better, before we can think about effective treatments.
fema4psyciatrists
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Re: Ideas of what's involved with not getting boozed

Unread post by fema4psyciatrists »

I suddenly stopped getting beer buzz or high/happy feeling from alcohol since PSSD too! It is really strange. Drinking alcohol or (being drunk) is now a really weird experience. And not fun in any way at all.

They give people similar medications to stop them feeling nicotine addiction too for stopping smoking now. Things like Champix and Bupropion. Who knows maybe our dopamine type system has been crushed in some way.
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Halan
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Re: Ideas of what's involved with not getting boozed

Unread post by Halan »

Well, I feel the effect of caffeine and nicotine...
But yeah, alcohol stopped to have this nice buzz! I don't like alcohol nowadays.

Wow, that's interesting...
Semogomes wrote: Fri Sep 04, 2020 8:20 am
Northern_Star wrote: Fri Sep 04, 2020 8:08 am The buzz from alcohol is associated with an increase in allopregnanolone levels (e.g. https://pubmed.ncbi.nlm.nih.gov/12700685/).

"PFS" patients also report that they do not get the buzz from alcohol anymore. An assessment of levels of neuroactive steroids in "PFS" patients showed dramatically lower allopregnanolone levels compared to controls (https://pubmed.ncbi.nlm.nih.gov/28408350/). The whole causative chain in the generation of neurosteroids is subject to proper androgenic signaling, which we know is dysregulated in "PFS" patients. It is increasingly obvious that the same is properly true for "PSSD".
Any idea of how can I overcome this?
Well, if this is really caused by low allopregnanolone levels, then low dose SSRI might help.

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670606/
Trazohell
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Re: Ideas of what's involved with not getting boozed

Unread post by Trazohell »

Yes it's from low Allopregnanolone levels. When I started taking Fluoxetine, I drank alcohol at a party on the third day. It was the most wonderful buzz I've ever had, I was literally "floating" over the dance floor, I felt so light. In fact, studies have shown that Fluvoxamine and Fluoxetine increase the levels of Neurosteroids, which makes me think about risking either of them in low dose.
June 2015 - April 2016 Fluoxetine
April 2016 - March 2017 Fluvoxamine
December 2017 9 days Trazodone
After Trazodone PSSD: loss of libido & spontaneous/night/morning erections, prostate/pelvic pain, genital numbness, lower sperm count, Anhedonia
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