Bupropion May have worsened me

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Markc1113
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Re: Bupropion May have worsened me

Unread post by Markc1113 »

So does that mean the Ed pills will not work for me now? How long with norepinephrine does it take to go down after taking something that increases it?
arahant
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Re: Bupropion May have worsened me

Unread post by arahant »

Markc1113 wrote:So does that mean the Ed pills will not work for me now? How long with norepinephrine does it take to go down after taking something that increases it?
Nope, I meant that the reason for sometimes ed pills might not work could be spikes of norepinephrine/epinephrine during sexual intercourse; it does not mean that 100% of the time It does not work.

Extreme worries can change norepinephrine/epinephrine much more than a single pill. It is a vicious cycle that can feed it all day long.

But when the parasympathetic nervous system is activated, the levels of norepinephrine/epinephrine reduces, naturally.
Also, there is another role that the parasympathetic nervous system plays is in sexual activity. In males, it stimulates smooth penile muscles to relax and allow blood to fill to the penis, making it rigid to prepare for sexual activity.

So, if you are worried before sex, there is no parasympathetic nervous system activation.
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BlackCat
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Re: Bupropion May have worsened me

Unread post by BlackCat »

When I was on Bupropion I had only mild improvements with libido, like 15%.
arahant
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Re: Bupropion May have worsened me

Unread post by arahant »

BlackCat wrote:When I was on Bupropion I had only mild improvements with libido, like 15%.
Low libido/energy is related to depression. These drugs are supposed to put a bit of arousal.

But for Buproprion, this effect is expected to kick in after a couple of weeks.
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Markc1113
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Re: Bupropion May have worsened me

Unread post by Markc1113 »

It helped me before which is why I took it again. This time it made it where I can’t get an erection 24hrs after taking it..
Markc1113
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Re: Bupropion May have worsened me

Unread post by Markc1113 »

But initially make it worse?
BlackCat
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Re: Bupropion May have worsened me

Unread post by BlackCat »

arahant wrote:
BlackCat wrote:When I was on Bupropion I had only mild improvements with libido, like 15%.
Low libido/energy is related to depression. These drugs are supposed to put a bit of arousal.

But for Buproprion, this effect is expected to kick in after a couple of weeks.
It's mostly from dopamine reuptake inhibition. Most stimulants give me better boners. I am obviously lacking in dopamine. Bupropion boosts norepinephrine and dopamine in the brain and both are important for sexual arousal.
Markc1113
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Re: Bupropion May have worsened me

Unread post by Markc1113 »

I think the norepinephrine made me not be able to get an erection? Day two of taking one pill and it did this
mrstaircase
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Re: Bupropion May have worsened me

Unread post by mrstaircase »

Bupropion causes rapid 5ht1a desinzitation. Much faster than any SSRI will do. Make of that what you will
Markc1113
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Re: Bupropion May have worsened me

Unread post by Markc1113 »

But it’s not supposed to do anything on 5ht1? Only mentions 5ht3 and weakly. I took one 150mg dose
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