Mirtazapine

Post any data on Treatments and experimentation.
Jaxx
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Re: Mirtazapine

Unread post by Jaxx »

Not saying you should go back on mirta, but as said the sedation is normal for 2 weeks but will decrease. Up to you if going back to an ssri is a better option, both has risks imo
Thomas
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Re: Mirtazapine

Unread post by Thomas »

sovietxrobot wrote: Thu Jun 11, 2020 11:59 am Mirtazapine, trazodone, or something similar should be a first-line treatment for PSSD. Sexual side effects from SSRIs are mostly linked to 5HT2 and possibly 5HT3.
I am quite surprised that so few people on this forum tried mirtazapine.
Its action is exactly what people believing in the "desensitization theory" would be looking for (directly by HT2A/C antagonism, indirectly on 5HT1 without increasing 5HT level!), in order to relieve symptoms (not to re-sensitize whatever).
There are some crash reports but:
1) Not that many and we have crash reports about everything!
2) I haven't see any scientific proof against it (but I haven't read everything :))

I did have some improvement of my slight PSSD with it (low dose: 7,5mg/day) before switching back to escitalopram. I am considering a trial if I don't improve in some months. Any advice / scientific feedback?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
sovietxrobot
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Re: Mirtazapine

Unread post by sovietxrobot »

Thomas wrote: Mon Feb 08, 2021 12:36 pm
sovietxrobot wrote: Thu Jun 11, 2020 11:59 am Mirtazapine, trazodone, or something similar should be a first-line treatment for PSSD. Sexual side effects from SSRIs are mostly linked to 5HT2 and possibly 5HT3.
I am quite surprised that so few people on this forum tried mirtazapine.
Its action is exactly what people believing in the "desensitization theory" would be looking for (directly by HT2A/C antagonism, indirectly on 5HT1 without increasing 5HT level!), in order to relieve symptoms (not to re-sensitize whatever).
There are some crash reports but:
1) Not that many and we have crash reports about everything!
2) I haven't see any scientific proof against it (but I haven't read everything :))

I did have some improvement of my slight PSSD with it (low dose: 7,5mg/day) before switching back to escitalopram. I am considering a trial if I don't improve in some months. Any advice / scientific feedback?
I have tried both in concert. Mirtazipine at 30mg gave me a modest benefit at first, but didnt have much lasting effect. I'm tapering off now because its made me put on a lot of weight. Trazodone has been pretty successful. Interestingly, I see a lot of benefits in the tapering period, even more so than at the initial dose.
Naczoz
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Re: Mirtazapine

Unread post by Naczoz »

Didnt you have muted orgasm after trazodone?
sovietxrobot
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Re: Mirtazapine

Unread post by sovietxrobot »

Naczoz wrote: Mon Feb 08, 2021 2:47 pm Didnt you have muted orgasm after trazodone?
Yes I have. I am hoping this resolves as I continue tapering down.
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