High dose magnesium and detoxing

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cdraham
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Re: High dose magnesium and detoxing

Unread post by cdraham »

fellow1 wrote: Mon Jul 06, 2020 12:28 pm confirming this. Magnesium helps erection quality and libido, even though i am not deficient
How much did you take for those benefits?
john099
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Re: High dose magnesium and detoxing

Unread post by john099 »

It would make sense that magnesium helps sexual issues - because it helps relax the pelvic floor - a lot of the sexual dysfunction we experience is due to tight pelvic floor. There are people on a CPPS forum that also experience benefits to sexual issues from magnesium. I just ordered some and will see if it helps.
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kpavel
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Re: High dose magnesium and detoxing

Unread post by kpavel »

Lithium by the way directly works with magnesium
https://pubmed.ncbi.nlm.nih.gov/11162580/
Magnesium notably helps cardiac arrhythmia.

And if interesting, I completely forgot it regulates receptor sensitivity

Agonist and Antagonist Binding to Rabbit Cortical 5-HT2A Receptors: Opposite Effects of Magnesium
Serotonin 5-HT2A and/or 5-HT2C receptors have been implicated in modulating the acquisition of the classically conditioned nictitating membrane response in the rabbit.1 Thus, we have undertaken the characterization of the 5-HT 2A receptor in rabbit brain using the agonist [125I]DOI, and the antagonists [3H]ketanserin and [3H]MDL 100,907. Autoradiographic studies using both [125I]DOI and [3H]ketanserin demonstrate a high density of 5-HT 2A receptors in adult New Zealand rabbit cortex. Therefore, binding studies were performed using membranes prepared from the frontal cortex. (3H]Ketanserin (New England Nuclear) and [3H]MDL 100,907 (Amersham) binding assays were performed at 25° C in 20 mM Tris HCl pH 7.4. Nonspecific binding was defined by 1 µM methysergide and I µM spiperone [3H]ketanserin and [3H]MDL 100,907, respectively. Ketanserin binding (in the presence of 100 nM prazosin) was consistent with 2 classes of binding sites. The high affinity ketanserin site had a Kd of approximately 1 nM, which is consistent with its reported affinity at 5-HT 2A receptors. The GTP analogue, Gpp(NH)p, at concentrations up to 100 mM had no effect on ketanserin binding. In contrast, magnesium dose-dependently inhibited ketanserin binding. The IC50 for DOI displacement of bound [3H]ketanserin was decreased approximately fourfold in the presence of 5 mM MgSO4. More extensive studies were carried out with the highly selective 5-HT 2A receptor antagonist, MDL 100,907. Saturation analysis demonstrated that the binding of MDL 100,907 was consistent with a single class of sites with a Kd of approximately 0.1 nM. As for ketanserin, Gpp(NH)p at concentrations up to 100 mM had no effect, whereas magnesium dose-dependently inhibited MDL 100,907 binding. MgSO4 (5 mM) decreased the affinity of [3H]MDL 100,907 by approximately fourfold. The IC50 for DOI displacement of bound [3H]MDL 100,907 was decreased in the presence of 5 mM MgSO4. As expected, Mg++ shifts the 5HT2A receptor toward the agonist high affinity state as demonstrated by the increased affinity of the agonist, DOI. Unexpectedly, Mg++ decreases the binding of the putative neutral antagonists ketanserin and MDL 100,907, suggesting that these compounds may actually be inverse agonists at the 5-HT2A receptor.

Many other things possible.

High fat food is more harmful for kidneys on low Mg2+ diet.
https://pubmed.ncbi.nlm.nih.gov/30848940/
Lithium can harm kidneys.
FrankG1178
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Re: High dose magnesium and detoxing

Unread post by FrankG1178 »

I’m also going to start pelvic floor PT. I sense some of my lack of pleasure is due to tightness given that my glutes are killing me - and they have since I got floxed and had some med changes. I’m hoping this is all physical as I’m still on 10mg lexapro and 150mg Wellbutrin xl.
john099
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Re: High dose magnesium and detoxing

Unread post by john099 »

There are a lot of drugs that can induce pelvic floor dysfunction - SSRI, Finasteride, Accutane, steroids, illegal drugs, antibiotics just to name a few. They must disturb some delicate process that keeps the pelvic floor muscles relaxed. Physcial therapy could maybe overide this fuckup but to what degree is the question. There have been some success stories from people with pelvic floor therapy. Of course its not addressing the underlying imbalance but at least can provide some benefit with no risk of getting worse.
Kratjebier
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Re: High dose magnesium and detoxing

Unread post by Kratjebier »

kpavel wrote: Mon Jul 06, 2020 1:38 pm Ketanserin binding (in the presence of 100 nM prazosin) was consistent with 2 classes of binding sites. The high affinity ketanserin site had a Kd of approximately 1 nM, which is consistent with its reported affinity at 5-HT 2A receptors. The GTP analogue, Gpp(NH)p, at concentrations up to 100 mM had no effect on ketanserin binding. In contrast, magnesium dose-dependently inhibited ketanserin binding. The IC50 for DOI displacement of bound [3H]ketanserin was decreased approximately fourfold in the presence of 5 mM MgSO4.
High fat food is more harmful for kidneys on low Mg2+ diet.
https://pubmed.ncbi.nlm.nih.gov/30848940/
Lithium can harm kidneys.
How works Prazosin for you in this case? I use now a Alpha blocker its calls Alfuzosin, but I red here Prazosin works better for anxiety too?
Cant found the study or proof of this, hope you can tell me more about this medication and how feels your body?
UKContributor
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Re: High dose magnesium and detoxing

Unread post by UKContributor »

I have PFS also taken Roaccutane, posted on PropHelp but recently took Glucosamine and radically relaxed pelvic floor although only issue related to that I had was urinary leakage after finishing peeing. It has stopped in a way and duration it hasn’t in two years of this. Still a tiny bit after but about 10% and I can feel the difference.
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kpavel
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Re: High dose magnesium and detoxing

Unread post by kpavel »

Kratjebier wrote: Sun Jul 12, 2020 2:47 am
kpavel wrote: Mon Jul 06, 2020 1:38 pm Ketanserin binding (in the presence of 100 nM prazosin) was consistent with 2 classes of binding sites. The high affinity ketanserin site had a Kd of approximately 1 nM, which is consistent with its reported affinity at 5-HT 2A receptors. The GTP analogue, Gpp(NH)p, at concentrations up to 100 mM had no effect on ketanserin binding. In contrast, magnesium dose-dependently inhibited ketanserin binding. The IC50 for DOI displacement of bound [3H]ketanserin was decreased approximately fourfold in the presence of 5 mM MgSO4.
High fat food is more harmful for kidneys on low Mg2+ diet.
https://pubmed.ncbi.nlm.nih.gov/30848940/
Lithium can harm kidneys.
How works Prazosin for you in this case? I use now a Alpha blocker its calls Alfuzosin, but I red here Prazosin works better for anxiety too?
Cant found the study or proof of this, hope you can tell me more about this medication and how feels your body?
Hi, in this quote above prazosin was used just to make ketanserin more selective. I never used prazosin. What I can speculate is if you have anxiety it might help, and it will help with erections. But I will have in mind some things:
1) Side effects https://www.drugs.com/sfx/prazosin-side-effects.html
2) Prazosin may cause problems with ejaculation (and with bladder function). Possibly with sensation?
3) In hypoxia alpha1adr can be upregulated.https://pubmed.ncbi.nlm.nih.gov/2539399/ I think problems with breathing and low oxygen in cells are characteristic for anxiety disorders, certainly for panic disorder. And alpha blockers mess with breathing https://jcsm.aasm.org/doi/10.5664/jcsm.8296
4) Nicotinamide helps anxiety and blood oxygenation and it could be it regulates excess contraction in a healthy way
https://pubmed.ncbi.nlm.nih.gov/10699482/
Go to my topic in research subforum, many of those sups really help to exclude excessive tension and overthinking.
Magnesium can be helpful too. Like for tremors or arrhythmia.
Kratjebier
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Re: High dose magnesium and detoxing

Unread post by Kratjebier »

[/quote]

How works Prazosin for you in this case? I use now a Alpha blocker its calls Alfuzosin, but I red here Prazosin works better for anxiety too?
Cant found the study or proof of this, hope you can tell me more about this medication and how feels your body?
[/quote]
Hi, in this quote above prazosin was used just to make ketanserin more selective. I never used prazosin. What I can speculate is if you have anxiety it might help, and it will help with erections. But I will have in mind some things:
1) Side effects https://www.drugs.com/sfx/prazosin-side-effects.html
2) Prazosin may cause problems with ejaculation (and with bladder function). Possibly with sensation?
3) In hypoxia alpha1adr can be upregulated.https://pubmed.ncbi.nlm.nih.gov/2539399/ I think problems with breathing and low oxygen in cells are characteristic for anxiety disorders, certainly for panic disorder. And alpha blockers mess with breathing https://jcsm.aasm.org/doi/10.5664/jcsm.8296
4) Nicotinamide helps anxiety and blood oxygenation and it could be it regulates excess contraction in a healthy way
https://pubmed.ncbi.nlm.nih.gov/10699482/
Go to my topic in research subforum, many of those sups really help to exclude excessive tension and overthinking.
Magnesium can be helpful too. Like for tremors or arrhythmia.
[/quote]
Sorry for misunderstanding, I dont know were too find else.
My problems are low libido, overactive pelvic floor and maybe too much adrenaline in hole my body?, depressed periods and anxiety.
I think Anxiety are worser because I feel not confidence cause my body gives me that feeling.

I have now Alfuzosin, but hearded Prazosin works better? but that medication we dont have anymore on the market.
I need proof, too import that stuff with permission of my doctor.
maybe JayR knows more?
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kpavel
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Re: High dose magnesium and detoxing

Unread post by kpavel »

Kratjebier wrote: Mon Jul 13, 2020 5:03 am
How works Prazosin for you in this case? I use now a Alpha blocker its calls Alfuzosin, but I red here Prazosin works better for anxiety too?
Cant found the study or proof of this, hope you can tell me more about this medication and how feels your body?
[/quote]
Hi, in this quote above prazosin was used just to make ketanserin more selective. I never used prazosin. What I can speculate is if you have anxiety it might help, and it will help with erections. But I will have in mind some things:
1) Side effects https://www.drugs.com/sfx/prazosin-side-effects.html
2) Prazosin may cause problems with ejaculation (and with bladder function). Possibly with sensation?
3) In hypoxia alpha1adr can be upregulated.https://pubmed.ncbi.nlm.nih.gov/2539399/ I think problems with breathing and low oxygen in cells are characteristic for anxiety disorders, certainly for panic disorder. And alpha blockers mess with breathing https://jcsm.aasm.org/doi/10.5664/jcsm.8296
4) Nicotinamide helps anxiety and blood oxygenation and it could be it regulates excess contraction in a healthy way
https://pubmed.ncbi.nlm.nih.gov/10699482/
Go to my topic in research subforum, many of those sups really help to exclude excessive tension and overthinking.
Magnesium can be helpful too. Like for tremors or arrhythmia.
[/quote]
Sorry for misunderstanding, I dont know were too find else.
My problems are low libido, overactive pelvic floor and maybe too much adrenaline in hole my body?, depressed periods and anxiety.
I think Anxiety are worser because I feel not confidence cause my body gives me that feeling.

I have now Alfuzosin, but hearded Prazosin works better? but that medication we dont have anymore on the market.
I need proof, too import that stuff with permission of my doctor.
maybe JayR knows more?
[/quote]
Yes, he certainly knows more on these drugs, maybe even experimented with prazosin.
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