Thoughts on 5HT1A antagonists?

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Tree
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Re: Thoughts on 5HT1A antagonists?

Unread post by Tree »

Gonzo wrote: Tue May 04, 2021 2:56 am
Tree wrote: Tue May 04, 2021 2:15 am
Calm Amygdala wrote: Mon May 03, 2021 4:55 pm

I thought that 5ht1a agonists tend to decrease serotoinin, as 5ht1a is an autoreceptor.
Presynaptic and postsynaptic 5ht1a receptors inhibit serotonin release. Agonists don't decrease serotonin. Most drugs/supplements that are 5ht1a agonists also increase serotonin.
So serotonin agonists may be dangerous?
Yes, taking them is very risky.
Calm Amygdala
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Re: Thoughts on 5HT1A antagonists?

Unread post by Calm Amygdala »

Tree wrote: Tue May 04, 2021 2:15 am
Calm Amygdala wrote: Mon May 03, 2021 4:55 pm
Tree wrote: Fri Feb 12, 2021 1:37 am 5ht1a antagonists will probably not sensitize the receptor because there is a large concentration of serotonin in our synapses from sert down regulation. Antagonists will just increase 5ht firing, by blocking 5ht1a receptors, which will worsen symptoms. We need to focus on finding ways to upregulate sert. All of the negative effects we experience are caused from down stream effects of permeant sert dysfunction induced by ssri. This seems to me like the most plausible explanation for why people have reported crashing from 5ht1a agonists. Most 5ht1a agonist medications/supplements not only target the 5ht1a receptor but they also increase serotonin. If sert is down regulated in pssd, and you take a 5ht1a agonist, serotonin will build up in your system until you crash (more 5ht1a desensitization).
I thought that 5ht1a agonists tend to decrease serotoinin, as 5ht1a is an autoreceptor.
Presynaptic and postsynaptic 5ht1a receptors inhibit serotonin release. Agonists don't decrease serotonin. Most drugs/supplements that are 5ht1a agonists also increase serotonin.
So if 5ht1a receptors inhibit serotonin release, wouldn't it follow that a 5ht1a agonist would inhibit serotonin release (decrease serotonin)?
Thomas
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Re: Thoughts on 5HT1A antagonists?

Unread post by Thomas »

Calm Amygdala wrote: Fri May 07, 2021 8:42 pm So if 5ht1a receptors inhibit serotonin release, wouldn't it follow that a 5ht1a agonist would inhibit serotonin release (decrease serotonin)?
Presynaptic agonists, yes. That’s what buspirone does, for instance.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
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