Thoughts on 5HT1A antagonists?

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Matthias66
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Thoughts on 5HT1A antagonists?

Unread post by Matthias66 »

I've been looking a lot into 5HT1a antagonists, and how they have the strong potential to reverse sexual side effects, and reverse the desensitization of the autoreceptors of 5HT1a receptor sites:

5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats:

https://academic.oup.com/ijnp/article/12/8/1045/677907

The 5-HT(1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing:

https://pubmed.ncbi.nlm.nih.gov/10528148/

There are a couple other articles I couldn't find, but seem to show a lot of promise in regards to 5HT1A antagonists, which from my understanding, similar to the SARI Trazodone, release more
Serotonin in the Post-Synaptic Cleft because of the blockage of the 5HT1A receptors.

The problem I am running into is that there are plenty of 5HT1A agonists, 5HT1A partial agonists, agonists of 5HT1B, 5HT1C, etc, but very few 5HT1a antagonists. Most are either discontinued or are experimental, and are not open for usage.

I hear good things about CBG oil as a medium strength 5HT1a antagonist.

Have you guys heard anything, or have any suggestions? I have a good feeling about this 5HT1a antagonist, but there needs to be more options for it.
Thomas
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Re: Thoughts on 5HT1A antagonists?

Unread post by Thomas »

https://en.wikipedia.org/wiki/5-HT1A_receptor
Cyproheptadine is frequently quoted here giving some relief (directly or with rebound) but having strong side effects.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | insomnia
Thomas
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Re: Thoughts on 5HT1A antagonists?

Unread post by Thomas »

Besides, some people had improvements with buspirone, which is a 5HT1A agonist.
Last edited by Thomas on Wed Sep 09, 2020 8:26 am, edited 1 time in total.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | insomnia
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dann888
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Re: Thoughts on 5HT1A antagonists?

Unread post by dann888 »

Thomas wrote: Wed Sep 09, 2020 4:03 am Besides, some people had improvements with buspirone, which is a 5HT1A antagonist.
Buspirone is an Agonist of 5ht1
Thomas
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Re: Thoughts on 5HT1A antagonists?

Unread post by Thomas »

Sorry, typo corrected
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | insomnia
Trazohell
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Re: Thoughts on 5HT1A antagonists?

Unread post by Trazohell »

Always the same discussions, we turn in circles...
June 2015 - April 2016 Fluoxetine
April 2016 - March 2017 Fluvoxamine
December 2017 9 days Trazodone
After Trazodone PSSD: loss of libido & spontaneous/night/morning erections, prostate/pelvic pain, genital numbness, lower sperm count, Anhedonia
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capitalCK
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Re: Thoughts on 5HT1A antagonists?

Unread post by capitalCK »

Matthias66 wrote: Tue Sep 08, 2020 10:04 pm I've been looking a lot into 5HT1a antagonists, and how they have the strong potential to reverse sexual side effects, and reverse the desensitization of the autoreceptors of 5HT1a receptor sites:

5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats:

https://academic.oup.com/ijnp/article/12/8/1045/677907

The 5-HT(1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing:

https://pubmed.ncbi.nlm.nih.gov/10528148/

There are a couple other articles I couldn't find, but seem to show a lot of promise in regards to 5HT1A antagonists, which from my understanding, similar to the SARI Trazodone, release more
Serotonin in the Post-Synaptic Cleft because of the blockage of the 5HT1A receptors.

The problem I am running into is that there are plenty of 5HT1A agonists, 5HT1A partial agonists, agonists of 5HT1B, 5HT1C, etc, but very few 5HT1a antagonists. Most are either discontinued or are experimental, and are not open for usage.

I hear good things about CBG oil as a medium strength 5HT1a antagonist.

Have you guys heard anything, or have any suggestions? I have a good feeling about this 5HT1a antagonist, but there needs to be more options for it.
I read that Lecozotan is a 5ht1-a antagonist but I don't know how to source it.

You mentioned CBG oil is also a 5ht1-a antagonist, so I wanted to thank you for that. That's rather easy to purchase!

Also, read that pindolol is a 5ht1a antagonist.
finities infinities
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Re: Thoughts on 5HT1A antagonists?

Unread post by finities infinities »

I'm also looking for a 5ht1a postsynaptic antagonist. But I can't find any herbal supplements that do.
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capitalCK
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Re: Thoughts on 5HT1A antagonists?

Unread post by capitalCK »

finities infinities wrote: Thu Sep 10, 2020 5:26 pm I'm also looking for a 5ht1a postsynaptic antagonist. But I can't find any herbal supplements that do.
CBG (not CBD). Comes from Hemp plant, so it is herbal.
Lokzo55
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Re: Thoughts on 5HT1A antagonists?

Unread post by Lokzo55 »

I am so SOOOO glad I found this thread.


I am a guy who can be CURED 6 hours after taking St. John's Wort Ze 117 extract.

I did a thread about it here:
https://raypeatforum.com/community/thre ... ine.33599/


NOW.... I am also a guy who gets CURED from a Cyproheptadine REBOUND.... That is, 1mg of cypro will make me NUMB and anhedonic, for 4 days. Then i get a miraculous rebound where I am cured.

So this means that my PSSD is very likely driven by the mofo 5-HT1A receptors. Because ALL MY ISSUES STARTED FROM ASHWAGANDHA. Ash desensitises the 5-ht1a.

So now that you mentioned CBG oil as a medium strength 5HT1a antagonist, this then means that if I respond to this, for SURE my issue is 5-HT1a.

I also get a window with ALCAR (Which is a 5-HT1A agonist... and then I crash).
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