Yes, taking them is very risky.Gonzo wrote: ↑Tue May 04, 2021 2:56 amSo serotonin agonists may be dangerous?Tree wrote: ↑Tue May 04, 2021 2:15 amPresynaptic and postsynaptic 5ht1a receptors inhibit serotonin release. Agonists don't decrease serotonin. Most drugs/supplements that are 5ht1a agonists also increase serotonin.Calm Amygdala wrote: ↑Mon May 03, 2021 4:55 pm
I thought that 5ht1a agonists tend to decrease serotoinin, as 5ht1a is an autoreceptor.
Thoughts on 5HT1A antagonists?
Re: Thoughts on 5HT1A antagonists?
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Re: Thoughts on 5HT1A antagonists?
So if 5ht1a receptors inhibit serotonin release, wouldn't it follow that a 5ht1a agonist would inhibit serotonin release (decrease serotonin)?Tree wrote: ↑Tue May 04, 2021 2:15 amPresynaptic and postsynaptic 5ht1a receptors inhibit serotonin release. Agonists don't decrease serotonin. Most drugs/supplements that are 5ht1a agonists also increase serotonin.Calm Amygdala wrote: ↑Mon May 03, 2021 4:55 pmI thought that 5ht1a agonists tend to decrease serotoinin, as 5ht1a is an autoreceptor.Tree wrote: ↑Fri Feb 12, 2021 1:37 am 5ht1a antagonists will probably not sensitize the receptor because there is a large concentration of serotonin in our synapses from sert down regulation. Antagonists will just increase 5ht firing, by blocking 5ht1a receptors, which will worsen symptoms. We need to focus on finding ways to upregulate sert. All of the negative effects we experience are caused from down stream effects of permeant sert dysfunction induced by ssri. This seems to me like the most plausible explanation for why people have reported crashing from 5ht1a agonists. Most 5ht1a agonist medications/supplements not only target the 5ht1a receptor but they also increase serotonin. If sert is down regulated in pssd, and you take a 5ht1a agonist, serotonin will build up in your system until you crash (more 5ht1a desensitization).
Re: Thoughts on 5HT1A antagonists?
Presynaptic agonists, yes. That’s what buspirone does, for instance.Calm Amygdala wrote: ↑Fri May 07, 2021 8:42 pm So if 5ht1a receptors inhibit serotonin release, wouldn't it follow that a 5ht1a agonist would inhibit serotonin release (decrease serotonin)?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
Symptoms: sexual & emotional numbness
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