In this thread: people who don't even have pssd and are still on meds, tqlk about stuff that won't cure pssd and claim it as a cure.
But I read your palaver and sophistries in good faith and still fail to see the scientific ground of your theory.
Something something acetylcholine and nmda. Okay. What about them? What's your point? What proof and research do you have in your defense?
My theory
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Re: My theory
Agreed acetylcholine is a major factor here. All 3 transmitters: Serotonin, Dopamine, Acetylcholine. And less about quantity, more about signaling.Alex51 wrote: ↑Mon Nov 23, 2020 7:47 am But I still insist, read and study sinking acetylcholine. Let's think a little less about 5HTA receivers. Erection, memory, learning, mental alertness, motivation, repair of neurons and myelin sheath, sensitivity to physical contact ... Everything is or has the action of acetylcholine.
regarding the repair of SSRI, it is known that chronic use damages dopamine receptors, and one of the hypotheses of PSSD is precisely this dopamine defect. I'm not "selling miracles", just an alternative that can work, as it did for me and other people. Invest heavily in choline and cysteine, along with cofactors.
Good test!
Re: My theory
So if it’s more about signaling and not amount available how do we correct that? If you guys are right, what is to be done, what do we try? I think several of us would be willing to test this theory if we knew what to try.
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Re: My theory
I would have to monitor your results individually, after making a few suggestions, to dial in doses on said suggestions. PM me if you'd like.
But to be general: CDP Choline, Coluracetam, SJW, Bacopa, and Lecithin. Again though - one needs to monitor your responses to make adequate adjustment suggestions. Starting template would be: 75/15/1.5G/1G, 2G respectively, daily.
You'd be achieving: SERT upregulation (Bacopa), 1A/2A receptor binding optimization (SJW, Lecithin), acetylcholine concentration increases, DA release (CDP Choline), and high affinity choline uptake (shuttling choline into intracellular compartments - Coluracetam).
Supporting research:
Bacopa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564644/
CDP Choline: https://pubmed.ncbi.nlm.nih.gov/1839138/
Coluracetam: https://pubmed.ncbi.nlm.nih.gov/8740080/
SJW: https://journals.sagepub.com/doi/abs/10 ... 0101500109
Effects SHOULD be: Better EQ, increased tactile sensation, increased libido, better climax sensation. But - the timeframe necessary to achieve gains varies from person to person. I believe Lecithin is a critical element of PSSD recovery via optimization of receptor binding and expression of, at the very least, Serotonin and acetylcholine receptors.
In a PSSD recovery protocol, focus should also be on raising total/free test, and optimizing androgen receptor expression.
This would be one experiment to try for the brave.
Re: My theory
Thanks for the response on this. I’m going to start gathering these
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Re: My theory
Outstanding post. One of the best on this forum, I don't know how many people are aware of that. My question is about dosages. I notice you say that you suggest 1 full gram of bacopa. Why such a high dosage? What extract are you referring to? I am currently taking 1 Synapsa a day (320 mg, 55% bacosides). I find it to be noticeably anti-dopaminergic, but am sticking with it for its TH and SERT upregulating qualities. Is that sufficient?rmichaelballow wrote: ↑Sat Feb 13, 2021 8:28 amI would have to monitor your results individually, after making a few suggestions, to dial in doses on said suggestions. PM me if you'd like.
But to be general: CDP Choline, Coluracetam, SJW, Bacopa, and Lecithin. Again though - one needs to monitor your responses to make adequate adjustment suggestions. Starting template would be: 75/15/1.5G/1G, 2G respectively, daily.
You'd be achieving: SERT upregulation (Bacopa), 1A/2A receptor binding optimization (SJW, Lecithin), acetylcholine concentration increases, DA release (CDP Choline), and high affinity choline uptake (shuttling choline into intracellular compartments - Coluracetam).
Supporting research:
Bacopa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564644/
CDP Choline: https://pubmed.ncbi.nlm.nih.gov/1839138/
Coluracetam: https://pubmed.ncbi.nlm.nih.gov/8740080/
SJW: https://journals.sagepub.com/doi/abs/10 ... 0101500109
Effects SHOULD be: Better EQ, increased tactile sensation, increased libido, better climax sensation. But - the timeframe necessary to achieve gains varies from person to person. I believe Lecithin is a critical element of PSSD recovery via optimization of receptor binding and expression of, at the very least, Serotonin and acetylcholine receptors.
In a PSSD recovery protocol, focus should also be on raising total/free test, and optimizing androgen receptor expression.
This would be one experiment to try for the brave.
What would you say to those who find bacopa to be anti-dopaminergic?
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