Substances worth further exploring/researching

Post any data on Treatments and experimentation.
Brain food
Posts: 348
Joined: Sat Aug 15, 2020 9:54 am
Contact:

Re: Substances worth further exploring/researching

Unread post by Brain food »

Ezogabine is another possible treatment. A recent study at the Icahn School of Medicine at Mount Sinai shows that it's effective in treating depression and anhedonia. "Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression." See links below:
https://www.mountsinai.org/about/newsro ... depression
https://www.psychcongress.com/article/e ... ent-target
https://scitechdaily.com/brain-ion-chan ... -symptoms/
User avatar
Meso
Posts: 1020
Joined: Tue Jan 22, 2019 3:00 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by Meso »

Brain food wrote: Tue Mar 09, 2021 10:36 pm Ezogabine is another possible treatment. A recent study at the Icahn School of Medicine at Mount Sinai shows that it's effective in treating depression and anhedonia. "Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression." See links below:
https://www.mountsinai.org/about/newsro ... depression
https://www.psychcongress.com/article/e ... ent-target
https://scitechdaily.com/brain-ion-chan ... -symptoms/
Very interesting!
I read about KCNQ2/3 and I really hope that newer (safe) antidepressants are developed based on this mechanism. I wonder if Ezogabine is available as an RC.
"The Research Zone" is permanently down.
You are welcome to join my Discord research server: Click Here
Brain food
Posts: 348
Joined: Sat Aug 15, 2020 9:54 am
Contact:

Re: Substances worth further exploring/researching

Unread post by Brain food »

Meso wrote: Wed Mar 10, 2021 8:04 am
Brain food wrote: Tue Mar 09, 2021 10:36 pm Ezogabine is another possible treatment. A recent study at the Icahn School of Medicine at Mount Sinai shows that it's effective in treating depression and anhedonia. "Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression." See links below:
https://www.mountsinai.org/about/newsro ... depression
https://www.psychcongress.com/article/e ... ent-target
https://scitechdaily.com/brain-ion-chan ... -symptoms/
Very interesting!
I read about KCNQ2/3 and I really hope that newer (safe) antidepressants are developed based on this mechanism. I wonder if Ezogabine is available as an RC.
Meso, what do you mean by an RC?
Frog
Posts: 292
Joined: Sun Feb 24, 2019 2:37 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by Frog »

Brain food wrote: Wed Mar 10, 2021 11:42 am
Meso wrote: Wed Mar 10, 2021 8:04 am
Brain food wrote: Tue Mar 09, 2021 10:36 pm Ezogabine is another possible treatment. A recent study at the Icahn School of Medicine at Mount Sinai shows that it's effective in treating depression and anhedonia. "Their study showed that ezogabine (also known as retigabine), a drug that opens KCNQ2/3 type of potassium channels in the brain, is associated with significant improvements in depressive symptoms and anhedonia in patients with depression." See links below:
https://www.mountsinai.org/about/newsro ... depression
https://www.psychcongress.com/article/e ... ent-target
https://scitechdaily.com/brain-ion-chan ... -symptoms/
Very interesting!
I read about KCNQ2/3 and I really hope that newer (safe) antidepressants are developed based on this mechanism. I wonder if Ezogabine is available as an RC.
Meso, what do you mean by an RC?
Research chemical
bockemossen
Posts: 26
Joined: Fri Apr 10, 2020 9:37 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by bockemossen »

Has anybody tried Chaihu-jia-Longgu-Muli or Yueju pill? Sounds promising for depression. I feel like I have to mention that they both have significant, perhaps strong CYP3a4 inhibition. At least in vitro. That means alot of drug interactions. I want to try it soon, I just have to change my regimen somewhat.
User avatar
Meso
Posts: 1020
Joined: Tue Jan 22, 2019 3:00 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by Meso »

Meso wrote: Sun Feb 07, 2021 5:50 am 16- Pitolisant: H3 receptor inverse agonist. This increases monoamine transmission by quite a bit.

17- Etifoxine: Multi-acting as a GABA-A positive allosteric modulator + increases natural production of neurosteroids + possible translocator protein (TSPO) agonist (helpful for chronic fatigue syndrome).
Added these 2 drugs to the list.
"The Research Zone" is permanently down.
You are welcome to join my Discord research server: Click Here
bockemossen
Posts: 26
Joined: Fri Apr 10, 2020 9:37 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by bockemossen »

Meso wrote: Sat Mar 20, 2021 12:57 am
Meso wrote: Sun Feb 07, 2021 5:50 am 16- Pitolisant: H3 receptor inverse agonist. This increases monoamine transmission by quite a bit.

17- Etifoxine: Multi-acting as a GABA-A positive allosteric modulator + increases natural production of neurosteroids + possible translocator protein (TSPO) agonist (helpful for chronic fatigue syndrome).
Added these 2 drugs to the list.
What about microdosing LSD/psilocybin? Maybe more for depression than PSSD. I’m thinking of combining the most active components of Chaihu-jia-Longgu-Muli (Bupleurum Chinense) and Yueju pill (gardenia jasminoides) with the semax I’m already using. Would that be overkill? And how could one combine that with microdosing psychedelics?
User avatar
Meso
Posts: 1020
Joined: Tue Jan 22, 2019 3:00 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by Meso »

bockemossen wrote: Fri Apr 02, 2021 11:28 pm
Meso wrote: Sat Mar 20, 2021 12:57 am
Meso wrote: Sun Feb 07, 2021 5:50 am 16- Pitolisant: H3 receptor inverse agonist. This increases monoamine transmission by quite a bit.

17- Etifoxine: Multi-acting as a GABA-A positive allosteric modulator + increases natural production of neurosteroids + possible translocator protein (TSPO) agonist (helpful for chronic fatigue syndrome).
Added these 2 drugs to the list.
What about microdosing LSD/psilocybin? Maybe more for depression than PSSD. I’m thinking of combining the most active components of Chaihu-jia-Longgu-Muli (Bupleurum Chinense) and Yueju pill (gardenia jasminoides) with the semax I’m already using. Would that be overkill? And how could one combine that with microdosing psychedelics?
It would be okay, I reckon. But keep in mind that excessive BDNF can cause hair loss.
"The Research Zone" is permanently down.
You are welcome to join my Discord research server: Click Here
Naczoz
Posts: 253
Joined: Fri Sep 18, 2020 4:37 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by Naczoz »

9-me-bc

Anybody? Looks like good symptomatic relief.
itsthe5ht2areceptor
Posts: 17
Joined: Sat Oct 24, 2020 1:18 pm
Contact:

Re: Substances worth further exploring/researching

Unread post by itsthe5ht2areceptor »

What do you guys think about androgen receptor facilitation?

-Weight Training
-L-Carnitine

Read some guy felt recovered after heavy weights + an AR receptor anabolic
Post Reply

Who is online

Users browsing this forum: Ahrefs [Bot] and 7 guests