I agree, let me rephrase, instead of designed, I would say expected effect. And the OP is clearly overdosing a drug that brought a lot of us here. That's freaking concerning.JakeLawe wrote: ↑Sun Dec 19, 2021 2:11 pmI don't think anybody "designed" sertraline.. ssris i think are accidental.. that's exactly the thing, no one really seems to knows what they do or not if anything at all in many cases. My impression is we're all in the dark regarding "mechanisms" .. it's a pill someone said helped him feel better in and pharma went from there. Most drugs we probably have no idea. Accidental.arahant wrote: ↑Sun Dec 19, 2021 11:52 amDude, seriously, you are really abusing sertraline like a street junkie expecting some "immediate high effect", be careful with this drug... This drug has slow metabolism and long half life, some paradoxical and immediate effect might happen, like you had "prior pssd", and many had reported paradoxical anxiety and energy increase after a single pill, which can even be placebo or some mild hypomanic during the first doses, but it probably faded as that's is not what sertraline is designed to do. But instead a numbing effect long term.FindGoodNickname wrote: ↑Sat Dec 18, 2021 10:06 pm I can take 500 mg of Sertraline and still not feel any big side effects. Sorry, I just had to try it...
So obviously, I am relatively immune / insensitive to it.
Before PSSD, 25 mg would already put me to the edge, I would be really nervous.
Perhaps that is an important information and could possibly explain PSSD? But that would go into the speculation forum...
I will write Dr. Healy about it.
How you doing regarding genital numbness these days, arahant?
You still taking methylphenidate and buspirone?
Ps. I am still taking both with constant effects, numbness doesn't bother me anymore.