Alcohol

This is for hypothesis and even educated speculation.
Joe1992
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Joined: Tue Jun 15, 2021 9:26 am
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Alcohol

Unread post by Joe1992 »

Guys, I have a low libido and issues with my erection. When I sit too long i feel a strange pain on my butt (pelvic floor). I only get very good erections the day(s) when I am hungover and I can masturbate several times. How is this? Does alcohol relax the muscles in the region of the pelvic floor? Did someone made the same experience?
CN9
Posts: 61
Joined: Sun May 17, 2020 1:49 pm
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Re: Alcohol

Unread post by CN9 »

me too. I'm sure there is a connection. I have a inflammation with edema at the https://en.wikipedia.org/wiki/Ischium.
Joe1992
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Joined: Tue Jun 15, 2021 9:26 am
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Re: Alcohol

Unread post by Joe1992 »

There has to be a connection. I don't want to be always hungover to be able to have sex.

Can you recommend something to improve the issues with the pelvic floor? Any supplement, medication or treatments?
CN9
Posts: 61
Joined: Sun May 17, 2020 1:49 pm
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Re: Alcohol

Unread post by CN9 »

no, I still live with it.

the question is, is there a connection to pssd?

you could make a mrt scan to check if the pudendus is affected by it.
ErgogenicHealth
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Re: Alcohol

Unread post by ErgogenicHealth »

5-HT1A agonists: alcohol drinking in rats and squirrel monkeys
Rationale: Increased alcohol intake after administration of low doses of 5-HT(1A )agonists is thought to be due to a reduction in 5-HT impulse flow due to activation of 5-HT(1A) somatodendritic receptors, whereas decreased alcohol drinking found after administration of higher doses of 5-HT(1A) agonists may be mediated by action at postsynaptic 5-HT(1A) receptors.

Objective: This study compares Long-Evans rats and squirrel monkeys to examine the hypothesis that low doses of the 5-HT(1A) selective agonists, 8-OH-DPAT and alnespirone, will preferentially increase, and at higher doses decrease alcohol drinking, and whether these effects can be antagonized by WAY 100635.

Methods: Male Long-Evans rats were induced to drink from two bottles, one containing a solution of 10% ethanol and 1% sucrose (w/v), the other containing an equally preferred concentration of sucrose. Squirrel monkeys also drank from two bottles, one containing a solution of 2% ethanol and 15% sucrose (w/v), the other, water.

Results: In rats, low doses of both 8-OH-DPAT (0.018-0.03 mg/kg) and alnespirone (0.3-3.0 mg/kg) increased alcohol drinking by ca. 100% without altering sucrose intake. The highest dose of 8-OH-DPAT (0.1 mg/kg) suppressed intake of both solutions without significant motor impairment. Pretreatment with WAY 100635 (0.1 mg/kg), shifted the entire dose-effect curve of 8-OH-DPAT to the right, and antagonized the effects of the 0.56 mg/kg dose of alnespirone. In the monkeys, administration of both agonists dose-dependently decreased alcohol intake and were behaviorally sedative.

Conclusions: These results support the hypothesis that in rats, 5-HT(1A) receptor stimulation activates somatodendritic receptors at lower doses and postsynaptic receptors at higher doses, each with opposite effects on alcohol intake. The absence of such biphasic dose-effect curves in monkeys suggests a different function of 5-HT(1A) somatodendritic receptors in rats and monkeys, at least with regard to alcohol drinking.
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