Postsynaptic AMPA receptor upregulation?

This is for hypothesis and even educated speculation.
CN9
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Re: Postsynaptic AMPA receptor upregulation?

Unread post by CN9 »

berberine instead of metformin?
Maxin
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Re: Postsynaptic AMPA receptor upregulation?

Unread post by Maxin »

nasibi wrote: Thu Apr 25, 2019 6:32 am I remember another compound IDRA-21. It is a positive allosteric modulator of the AMPA receptor. Would be a good combo with 7,8 DHF and maybe Cerebrolysine for those who can afford.

Other compounds like Etifoxine, 5a-DHP, Gelsemium
sempervirens, NSI-189
and BPC-157 can also help if your goal is neurogenesis. The first three work by increasing allopregnenalone. Regarding Metformin I think it suppresses mTOR. Not sure if that would be bad for our purposes.
Careful with bpc-157 lots of reports it’s causing irreversible anhedonia symptoms.
Calm Amygdala
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Re: Postsynaptic AMPA receptor upregulation?

Unread post by Calm Amygdala »

Any updates on this? Fascinating thread. Meso, are you saying that metformin would block the antidepressant effects of ketamine?
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