Ghost: regarding PSSD subtypes

This is for hypothesis and even educated speculation.
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Ghost
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Re: Ghost: regarding PSSD subtypes

Unread post by Ghost »

I'm racking my brain trying to think this through a bit more - thinking of the different types of PSSD as I had imagined it for a while now. These don't really overlap easily with your categories, but maybe they help. I usually thought of things based on what helped with treatments, and not as much with causes. This is a really rough sketch of things, just kinda spitballing.

- Dopamine-induced cures. Wellbutrin is the oldest one in the book. Then some others came along with other Dopamine Agonists

- Testosterone or other hormone cures: Usually someone would notice "whoops, this hormone is wrong" and then a few T shots later they are better.

- Inositol - It's cured a few people throughout the years. Usually in the people it helps, it first makes their memory SHIT. I assumed through 5ht2c receptors was the mechanism.

- Antibiotics/antifungals: Would come if symptoms were from an overgrowth of a parasite or something similar. There was a day where my numbness was totally cured on nystatin. Maybe also inflammatory.

- Depression: I think some people simply go into a deeper depression off of SSRIs, and only when they go back on a drug does their libido come back. This is a minority, but it exists.

- SJW/ Low dose reinstatement. I assumed through some sort of neurosteroid process.

- Pelvic floor/nerve entrapment / peripheral fibers or maybe a gut connection. Also possible inflammatory cause.

That's how I came up with the idea of splitting into:

Psychological, Physical, hormonal, neurological.

---
- Medical Student & Friendly poltergeist - Lexapro Sept '14. [Hx] [PSSD Lab] [r/PSSD] [Treatment Plan] - Add "Ghost" in replies so I see it :)
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Ghost
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Re: Ghost: regarding PSSD subtypes

Unread post by Ghost »

As for me, I'm still thinking of the things you posted on my log a few weeks ago - work on my end has been a standstill while studying.

I've thought of some sort of similarity to autism-spectrum disorders (something I've always been a bit close to but always tested out of due to my social skills). More curious here about the repetitive behaviors and the immune dysfunction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243332/

More on GR down-regulation: I think this could be important. Prednisolone wouldn't be a bad idea. But maybe we could use something longer-lasting. Has anyone on the forum taken one of these since PSSD? I'm assuming the answer will be yes, they are pretty common meds.
https://www.ncbi.nlm.nih.gov/pubmed/8574285

"After 24 h treatment with 1 x 10(-5) M cortisol, GR mRNA levels were only marginally suppressed (90% of the control), while prednisolone and dexamethasone suppressed GR mRNA levels to 67 and 57%, respectively. These differences may relate to the biological activities of these glucocorticoids. In time course studies, GR mRNA levels of the cells treated with cortisol and prednisolone decreased to the minimum levels within 4 h and then recovered gradually, while those treated with dexamethasone reached the minimum level at 8 h and remained suppressed for more than 24 h. These differences may relate to the biological half-lives of these glucocorticoids."

I haven't tried Sarcosine before...Not a bad idea for OCD as well.
I still have forskolin, and am game to do anything with chilis whenever, I love spicy food.
and obviously I still have psilocybin.

Hmm. I might move some of this over to my intro thread at some point but thought it fit the mold here for now.
First step: To restore LTP, glutamatergic function has to be restored. The most straightforward step is restoring HPA axis reactivity in order to restore LTP/LTD balance through cortisol's glutamate releasing effect + endocannabinoid interaction. Reversal of antidepressant-induced upregulation of GR is essential.

Second step: To keep neurogenesis enhanced, in order to prevent re-emergent depression and anxiety. TrkB upregulation should be enough, but boosting BDNF won't hurt.

Third step: To restore nerve conductance, reversing antidepressant-induced desensitization of transient receptor potential (TRP) channels. The affected channels are: TRPV1, TRPV3 and TRPV4, with possible involvement of TRPC4 since it colocalizes with 5HT2B. Oral capsaicin can cause central sensitization and paradoxical sensitization of TRPV1 downstream. Inositol can upregulate 5HT2 receptors.

So, final regimen would look something like this:
- Prednisolone: GR downregulation (any long acting corticosteroid could work).
- Metformin: TrkB upregulation + BDNF boost (10 mg boron to keep SHBG down). Preventing Prednisolone's toxic effect on neurogenesis. For 1-3 months, then withdraw very slowly from the corticosteroid.

After that:
- Metformin: Still taking it.
- Psilocybin: Low dose, for further glutamate disinhibition, further AMPA activation.
- Sarcosine: NMDA potentiation.
- Inositol: 18 g. 5HT2A/B upregulation. We'll deal with 2C downregulation later.
- Forkskolin: SERT activation, to keep serotonin from desensitizing receptors again.
- Adding hot chili powder to 2 meals per day. The hotter, the better.
- Medical Student & Friendly poltergeist - Lexapro Sept '14. [Hx] [PSSD Lab] [r/PSSD] [Treatment Plan] - Add "Ghost" in replies so I see it :)
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Meso
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Re: Ghost: regarding PSSD subtypes

Unread post by Meso »

@Ghost, categorizing PSSD is going to be difficult since with adding more variants we will end up with 15+ subtypes. Most people don't have free access to medications, so I think it's better to try and make an educated guess regarding the cause/etiology, so people would have to go out of their way to get drugs that could be the most helpful for their situation based on their symptoms.

I'm currently taking licorice root extract in my attempt to curing my PSSD. I dislike its estrogenic effects but I'm using a low dose. I hope this works.
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kamikaz3
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Re: Ghost: regarding PSSD subtypes

Unread post by kamikaz3 »

Ghost wrote:There was a day where my numbness was totally cured on nystatin.
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Nystatin reduces cortisol.

I think this is similiar to cushings syndrome.

Anyone have lots of stretch marks?

My body is covered in them, they were purple when younger.

Cortisol --> Translates into excess nor adrenaline

Adrenaline = Vasoconstriction
Cortisol = makes you numb, it's a stress hormone.

Coffee raises Cortisol, it's the reason it has no effect now.

SSRI's raise Cortisol.

Cortisol effects 5ht1a auto receptor sensitivity.

This could effect the natural homeostasis, we might be stuck in some loop where the receptor is causing chronic cortisol elevation.

I also have sleep apnoea since I was 16, this further raises cortisol and contributes to my cognitive decline.

SSRI's reduce nNOS expression. I took Paxil, it's the worst offender regarding this.

The elevated noradrenaline, cortisol, and reduced nNOS expression causes vasoconstriction. You need some type of 'blood' response to feel excited. No doubt there are cognitive factors in play but taking a Cialis definitely helps in becoming aroused as there is a response.

Seems pretty s1mple.


Licrorice increases Cortisol, I doubt this would help... instead make things worse.

Who has high blood pressure?
finities infinities
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Re: Ghost: regarding PSSD subtypes

Unread post by finities infinities »

I agree with you hypothesis! I have extreme vasoconstriction but my blood pressure is low.
angeloinvolo
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Re: Ghost: regarding PSSD subtypes

Unread post by angeloinvolo »

PSSD + cognitive
My PSSD had some improvements. I recognize the last types of pssd you wrote in the first steps of my PSSD story.
I had no anxiety, no emotions, sleepless nights and other physical problems.
In this 2 years this problems had solved but I still have problems with sex and memory and sense of time.
Someone knows the origin of this change and improvements in the emotional area while perhaps the memory got worse? Have you got any theory about It?
Thank you
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Seriouslyseeking
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Re: Ghost: regarding PSSD subtypes

Unread post by Seriouslyseeking »

Pure Pssd seems to be my subtype.is there any supplements or any way I can reverse it? Any help would be greatly appreciated..
defmyst
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Re: Ghost: regarding PSSD subtypes

Unread post by defmyst »

Seriouslyseeking wrote: Thu Jun 04, 2020 9:03 pm Pure Pssd seems to be my subtype.is there any supplements or any way I can reverse it? Any help would be greatly appreciated..
Same with me.

I have severe erectile dysfunction (plus overall smaller erections compared to pre-PSSD) and almost no libido.

I am taking tadalafil (cialis) which only marginally improved things. I am also taking L-citrulline (which is supposed to help with erections) and a Saffron extract for libido. Haven't noticed any significant changes yet.
Trazohell
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Re: Ghost: regarding PSSD subtypes

Unread post by Trazohell »

Type 3 PSSD fit perfect to me.
But what explain pelvic floor symptoms? Adrenals? Hormones? Brain dysfunction?
June 2015 - April 2016 Fluoxetine
April 2016 - March 2017 Fluvoxamine
December 2017 9 days Trazodone
After Trazodone PSSD: loss of libido & spontaneous/night/morning erections, prostate/pelvic pain, genital numbness, lower sperm count, Anhedonia
JLo22
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Re: Ghost: regarding PSSD subtypes

Unread post by JLo22 »

We're currently in the process of sending emails to everyone who has reported PSSD or PGAD to us via a RxISK Report. This is still ongoing and will probably take a few more days.

If you know some PSSD sufferers who would like their details passed onto the new research group, but who haven't yet completed reports, they can still complete a report on this link and we'll contact them in due course.

We received your email and will forward your details to the research group.

The RxISK Team

https://rxisk.org/experiencing-a-drug-side-effect/
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