Histamine's involvement in PSSD: research
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Re: Histamine's involvement in PSSD: research
Seems I have to withdraw my points about taking antihistamines. When I took Kutaj/Kutaja as an H3-antagonist, which raises histamine (fpr H1 and H2), I truly didn't feel that well, but libido seemed unaffected or normal, in other words "not bad". When I then took the antihistamines to normalize myself, I took a deep slump in libido and motivation. There might also have been other causes, but it seems related. Now when I took again a bit of Kutaj, my motivation and also libido seem to improve, without an adverse effects yet.
Re: Histamine's involvement in PSSD: research
Mast Cell activation syndrome is something I think I’ve been dealing with since I started getting pssd. I suspect there’s a large number of us who have an underlying connective tissue disorder like ehlers danlos or joint hypermobility syndrome which is commonly paired with mast cell activation and histamine issues.Meso wrote: ↑Fri May 24, 2019 8:18 pm Post migrated to:
https://www.theresearchzone.com/post/wh ... ay-in-pssd
Thanks for understanding.
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Re: Histamine's involvement in PSSD: research
I actually have a mild case of ehlers danlos. What does this mean? If you cure the mast cell activation syndrome, you cure the pssd?pubh12 wrote: ↑Thu Jun 11, 2020 2:27 amMast Cell activation syndrome is something I think I’ve been dealing with since I started getting pssd. I suspect there’s a large number of us who have an underlying connective tissue disorder like ehlers danlos or joint hypermobility syndrome which is commonly paired with mast cell activation and histamine issues.Meso wrote: ↑Fri May 24, 2019 8:18 pm Post migrated to:
https://www.theresearchzone.com/post/wh ... ay-in-pssd
Thanks for understanding.
Re: Histamine's involvement in PSSD: research
I remember one person on propecia recovered with l-histidine.
https://www.ncbi.nlm.nih.gov/pmc/articl ... pressin%2CIt is well documented that an administration of histamine via either the iv or icv route produces an HPA response 13 14 15 16 17 18, and that the HPA activation induced by histamine seems to be caused indirectly via activation of hypothalamic neurons or release of neurotransmitters, including CRF, arginin-vasopressin, and oxytocin
Re: Histamine's involvement in PSSD: research
I doubt it’s that simple. It could help but it might only play a small part I really have no idea. Having EDS means tight muscles anyway since out hips and everything are so lax, pelvic floor dysfunction seems like it would be so common in it.HereToHeal wrote: ↑Thu Jun 11, 2020 11:43 amI actually have a mild case of ehlers danlos. What does this mean? If you cure the mast cell activation syndrome, you cure the pssd?pubh12 wrote: ↑Thu Jun 11, 2020 2:27 amMast Cell activation syndrome is something I think I’ve been dealing with since I started getting pssd. I suspect there’s a large number of us who have an underlying connective tissue disorder like ehlers danlos or joint hypermobility syndrome which is commonly paired with mast cell activation and histamine issues.Meso wrote: ↑Fri May 24, 2019 8:18 pm Post migrated to:
https://www.theresearchzone.com/post/wh ... ay-in-pssd
Thanks for understanding.
Re: Histamine's involvement in PSSD: research
I also have MCAS / EDS / POTS since getting PSSD - or do I even have PSSD or is it those issues triggered by certain drugs supplements and mold exposure? I think that it also explains my pelvic floor dysfunction. MCAS can really explain a ton of PSSD symptoms. But I feel like if that was what we all were experiencing then people on this forum would have figured that out already.
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