Wellbutrin and 5HTA1

This is for hypothesis and even educated speculation.
PSSD_Throwaway28
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Wellbutrin and 5HTA1

Unread post by PSSD_Throwaway28 »

Hi guys,

Browsing the forums, it seems that the most popular theory regarding PSSD is that, in certain cases, use of SNRI's/SSRI's causes desensitization of the 5HTA1 receptors that persists even after the drug is discontinued. However, I'm having a little bit of trouble squaring this hypothesis with the fact that: (1) Wellbutrin typically resolves the sexual side effects of SSRI's that occur while people are taking them and (2) Wellbutrin seems to be the most promising drug in terms of improving the condition of people with PSSD - either temporarily or permanently.

The reason I have trouble squaring these two things is that Wellbutrin has also been shown to cause desensitization of the 5HTA1 receptor early on. In fact, this is part of the reason why it is sometimes recommended as an adjunct therapy to increase the effectiveness of SSRI's. Given this, if sexual side-effects were caused by 5HTA1 desensitization, wouldn't Wellbutrin tend to make things worse?

Am I missing something here?
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Lusitanic
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Re: Wellbutrin and 5HTA1

Unread post by Lusitanic »

Wellbutrin is overrated, for me, it made things worse.
work good for smoke cessation and appetite supressant....
clong4324
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Re: Wellbutrin and 5HTA1

Unread post by clong4324 »

Agreed there's got to be something to this since Wellbutrin directly reinstated my pssd. history: Prozac 2 months-->overnight light switch-like pssd, 6 months later tried zoloft which reinstated all sexual normalcy 100% for 2.5 years. Stopped zoloft w/ 2 week taper, crashed into debilitating withdrawal (inhuman depression) which would not let up after 6 weeks, for which i took wellbutrin just to get out of bed and finish school. Within a few weeks maybe a month on wellbutrin, hit with the very same "light switch" like overnight pssd.
arahant
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Re: Wellbutrin and 5HTA1

Unread post by arahant »

clong4324 wrote: Sun Nov 01, 2020 11:14 am tried zoloft which reinstated all sexual normalcy 100% for 2.5 years. Stopped zoloft w/ 2 week taper, crashed into debilitating withdrawal (inhuman depression) which would not let up after 6 weeks.
Wait, are you claiming Zoloft gave your normal sex life for 2.5 years?
That's impressive.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
CN9
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Re: Wellbutrin and 5HTA1

Unread post by CN9 »

Lusitanic wrote: Tue May 05, 2020 6:29 pm Wellbutrin is overrated
This!
sovietxrobot
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Re: Wellbutrin and 5HTA1

Unread post by sovietxrobot »

PSSD_Throwaway28 wrote: Tue May 05, 2020 5:44 pm Hi guys,

Browsing the forums, it seems that the most popular theory regarding PSSD is that, in certain cases, use of SNRI's/SSRI's causes desensitization of the 5HTA1 receptors that persists even after the drug is discontinued. However, I'm having a little bit of trouble squaring this hypothesis with the fact that: (1) Wellbutrin typically resolves the sexual side effects of SSRI's that occur while people are taking them and (2) Wellbutrin seems to be the most promising drug in terms of improving the condition of people with PSSD - either temporarily or permanently.

The reason I have trouble squaring these two things is that Wellbutrin has also been shown to cause desensitization of the 5HTA1 receptor early on. In fact, this is part of the reason why it is sometimes recommended as an adjunct therapy to increase the effectiveness of SSRI's. Given this, if sexual side-effects were caused by 5HTA1 desensitization, wouldn't Wellbutrin tend to make things worse?

Am I missing something here?
someone else made this claim and I couldn't find any good evidence that Wellbutrin effects 5HT1A. its a dopamine reuptake inhibitor, I dont see how it would interact with 5HT1A. I am not sold on the 5HT1A desensitization theory either.
arahant
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Re: Wellbutrin and 5HTA1

Unread post by arahant »

sovietxrobot wrote: Mon Nov 02, 2020 12:52 pm
PSSD_Throwaway28 wrote: Tue May 05, 2020 5:44 pm Hi guys,

Browsing the forums, it seems that the most popular theory regarding PSSD is that, in certain cases, use of SNRI's/SSRI's causes desensitization of the 5HTA1 receptors that persists even after the drug is discontinued. However, I'm having a little bit of trouble squaring this hypothesis with the fact that: (1) Wellbutrin typically resolves the sexual side effects of SSRI's that occur while people are taking them and (2) Wellbutrin seems to be the most promising drug in terms of improving the condition of people with PSSD - either temporarily or permanently.

The reason I have trouble squaring these two things is that Wellbutrin has also been shown to cause desensitization of the 5HTA1 receptor early on. In fact, this is part of the reason why it is sometimes recommended as an adjunct therapy to increase the effectiveness of SSRI's. Given this, if sexual side-effects were caused by 5HTA1 desensitization, wouldn't Wellbutrin tend to make things worse?

Am I missing something here?
someone else made this claim and I couldn't find any good evidence that Wellbutrin effects 5HT1A. its a dopamine reuptake inhibitor, I dont see how it would interact with 5HT1A. I am not sold on the 5HT1A desensitization theory either.
An amphetamine substituted (bupropion) being put alongside SSRIs as desensitization agents?
It's kinda weird that some theories have become the number one agent of psychological terror among sufferers. :o This one has become so strong that these days one poster on Reddit was completely hopeless because after his "internet self-research", he realized that cigarettes cause desensitization of these receptors, according to some rat studies, so that's why he was feeling shit... But he couldn't understand that the study was to evaluate tobacco addiction, cravings due to this hypothetical desensitization...The layman cannot understand the hierarchy in biomedical research...they don't imagine that the majority mechanisms in vitro are not confirmed in animals and the same happens from rats to human beings...from thousands of drug candidates, sometimes zero passes the test of the same action in humans.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
clong4324
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Re: Wellbutrin and 5HTA1

Unread post by clong4324 »

arahant wrote: Sun Nov 01, 2020 3:13 pm
clong4324 wrote: Sun Nov 01, 2020 11:14 am tried zoloft which reinstated all sexual normalcy 100% for 2.5 years. Stopped zoloft w/ 2 week taper, crashed into debilitating withdrawal (inhuman depression) which would not let up after 6 weeks.
Wait, are you claiming Zoloft gave your normal sex life for 2.5 years?
That's impressive.
Yes--6 weeks 20mg prozac, age 17, pssd overnight. Lasted 5-6 months. Took zoloft, 50mg, everything resumed normal for 2.5 years. Even tapered and withdrew completely for 4 months during that time, and remained 100% normal. Then resumed zoloft again (purely to deal with the debilitating withdrawal--oh the irony) and remained normal. About 6 month later, quit cold turkey. Immediately crashed into a depression unlike anything I could ever describe or imagine. If I lacked the presence of mind to know it was just the drug withdrawal, I'm sure I would have killed myself. After a month of that, I took wellbutrin simply as a means to literally be able to get out of bed (which was nothing I had ever experienced pre-SSRI of course, so this "it's just our disease returning" is total b.s.). After about a month or so +/- on wellbutrin, it all came back like a light switch, overnight. Hypogonadism, ED, everything, weird dark-looking veins appeared in my dick when flacid where previously none were visible in that state. Docs of course just dismissed it and prescribed viagra, which did nothing.
Markc1113
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Re: Wellbutrin and 5HTA1

Unread post by Markc1113 »

Wait, so I don’t obviously know this, as no one will, but I’ve seen you blame wellebutrin for this on several social posts, yet your saying a month prior to your crash you had cold turkeyed Zoloft? I mean I hate to point it out but it could have just as easily been cold turkeying the Zoloft. I was a hundred percent fine when taking viibryd, yet when I quit it cold turkey I got pssd and it didn’t happen immediately, it took 2-3 weeks before it happened. So while I do think a lot of drugs can cause pssd and it could have possibly been the wellebutrin(even though several including myself have had help from it), as much as you have pointed to it, I do think you might consider the alternative that cold turkeying an ssri could have contributed.
Markc1113
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Re: Wellbutrin and 5HTA1

Unread post by Markc1113 »

Even if it was delayed, as a lot of people have had it happen like that.
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