NAD+ deficiency?

This is for hypothesis and even educated speculation.
cdraham
Posts: 448
Joined: Thu Jul 04, 2019 10:39 am
Contact:

NAD+ deficiency?

Unread post by cdraham »

I came across this paper, any useful?

https://osf.io/z64pj/

Looks abit like bro-science. Anyways we could be deficient in NAD+?

Im taking Niacinamide + d-ribose now.

Also, I will try to avoid inflammatory triggers like wheat, sugar, alcohol

I also ordered black seed oil capsules, it promotes the conversion through SIRT1 -> AMPK

Or you could also do NAD+ IV, that might be the most effective way

https://www.vice.com/en_us/article/bn3v ... -injection
User avatar
kpavel
Posts: 323
Joined: Thu Aug 15, 2019 7:50 am
Contact:

Re: NAD+ deficiency?

Unread post by kpavel »

cdraham wrote: Sun May 24, 2020 10:28 am I came across this paper, any useful?

https://osf.io/z64pj/

Looks abit like bro-science. Anyways we could be deficient in NAD+?

Im taking Niacinamide + d-ribose now.

Also, I will try to avoid inflammatory triggers like wheat, sugar, alcohol

I also ordered black seed oil capsules, it promotes the conversion through SIRT1 -> AMPK

Or you could also do NAD+ IV, that might be the most effective way

https://www.vice.com/en_us/article/bn3v ... -injection
The paper is good, only it doesn't look written by a scientist
Here's basically the same by a professional, Rhonda Patrick, she's cool)
https://www.youtube.com/watch?v=hggLOXhFRxc
And have some to add on IV route;)
Acetyl-l-Carnitine in the Treatment of Anhedonia, Melancholic and Negative Symptoms in Alcohol Dependent Subjects
https://pubmed.ncbi.nlm.nih.gov/21256179/
Objective: Aim of this randomized, double-blind, placebo-controlled study was to evaluate the efficacy of Acetyl-l-Carnitine (ALC), at different dosages, on specific anhedonic symptoms in detoxified alcohol dependent subjects. Secondary endpoints were the effect of ALC on melancholic and negative symptoms.
Method: Sixty-four anhedonic alcohol dependent patients with minor or absent withdrawal symptoms were randomized: 23 received ALC at a dosage of 3g/day, 21 received ALC at a dosage of 1g/day, and 20 were given placebo. ALC was given intravenously for 10days, followed by 80days of oral treatment plus a follow-up period of 45days. The presence of anhedonic symptoms was determined by the SHAPS (Snaith-Hamilton Pleasure Scale) and the VASa (Visual Analogue Scale for Anhedonia); negative and melancholic symptoms were evaluated by the SANS (Scale for the Assessment of Negative Symptoms), and the BRMS (Bech-Rafaelsen Melancholia Scale).
Results: The natural course of anhedonia in the placebo group showed a decline until day 30 and remains stable for the rest of the study. Intravenously ALC accelerated the improvement of anhedonia reaching constant low levels early, on day 10. At this step levels of anhedonia (SHAPS, VASa) and melancholic symptoms (BRMES) resulted significantly reduced (p<0.05) in both the ALC 3g and ALC 1g groups with respect to placebo; SANS scores significantly reduced only in the ALC 1g respect to placebo (p=0.014). During oral treatment with ALC, anhedonia scores did not differ from placebo.
Conclusion: Intravenously ALC was effective in accelerating the abstinence-associated improvement of anhedonia, melancholic and negative symptoms, whereas oral ALC treatment starting on day 10 showed no further improvements. Accordingly, in alcohol dependent subjects, ALC may be considered as a new potentially useful drug for the treatment of anhedonia.
plus this recovery claim from a guy who had PFS
https://www.longecity.org/forum/topic/1 ... rventions/
cdraham
Posts: 448
Joined: Thu Jul 04, 2019 10:39 am
Contact:

Re: NAD+ deficiency?

Unread post by cdraham »

kpavel wrote: Mon May 25, 2020 2:15 am
cdraham wrote: Sun May 24, 2020 10:28 am I came across this paper, any useful?

https://osf.io/z64pj/

Looks abit like bro-science. Anyways we could be deficient in NAD+?

Im taking Niacinamide + d-ribose now.

Also, I will try to avoid inflammatory triggers like wheat, sugar, alcohol

I also ordered black seed oil capsules, it promotes the conversion through SIRT1 -> AMPK

Or you could also do NAD+ IV, that might be the most effective way

https://www.vice.com/en_us/article/bn3v ... -injection
The paper is good, only it doesn't look written by a scientist
Here's basically the same by a professional, Rhonda Patrick, she's cool)
https://www.youtube.com/watch?v=hggLOXhFRxc
And have some to add on IV route;)
Acetyl-l-Carnitine in the Treatment of Anhedonia, Melancholic and Negative Symptoms in Alcohol Dependent Subjects
https://pubmed.ncbi.nlm.nih.gov/21256179/
Objective: Aim of this randomized, double-blind, placebo-controlled study was to evaluate the efficacy of Acetyl-l-Carnitine (ALC), at different dosages, on specific anhedonic symptoms in detoxified alcohol dependent subjects. Secondary endpoints were the effect of ALC on melancholic and negative symptoms.
Method: Sixty-four anhedonic alcohol dependent patients with minor or absent withdrawal symptoms were randomized: 23 received ALC at a dosage of 3g/day, 21 received ALC at a dosage of 1g/day, and 20 were given placebo. ALC was given intravenously for 10days, followed by 80days of oral treatment plus a follow-up period of 45days. The presence of anhedonic symptoms was determined by the SHAPS (Snaith-Hamilton Pleasure Scale) and the VASa (Visual Analogue Scale for Anhedonia); negative and melancholic symptoms were evaluated by the SANS (Scale for the Assessment of Negative Symptoms), and the BRMS (Bech-Rafaelsen Melancholia Scale).
Results: The natural course of anhedonia in the placebo group showed a decline until day 30 and remains stable for the rest of the study. Intravenously ALC accelerated the improvement of anhedonia reaching constant low levels early, on day 10. At this step levels of anhedonia (SHAPS, VASa) and melancholic symptoms (BRMES) resulted significantly reduced (p<0.05) in both the ALC 3g and ALC 1g groups with respect to placebo; SANS scores significantly reduced only in the ALC 1g respect to placebo (p=0.014). During oral treatment with ALC, anhedonia scores did not differ from placebo.
Conclusion: Intravenously ALC was effective in accelerating the abstinence-associated improvement of anhedonia, melancholic and negative symptoms, whereas oral ALC treatment starting on day 10 showed no further improvements. Accordingly, in alcohol dependent subjects, ALC may be considered as a new potentially useful drug for the treatment of anhedonia.
plus this recovery claim from a guy who had PFS
https://www.longecity.org/forum/topic/1 ... rventions/
Very interesting, I might try this myself.
alteredhomeostasis
Posts: 196
Joined: Sat Sep 23, 2017 5:21 pm
Contact:

Re: NAD+ deficiency?

Unread post by alteredhomeostasis »

There’s like at least 10 essential cellular processes that use these and if anything went wrong with them u would probably die.
cdraham
Posts: 448
Joined: Thu Jul 04, 2019 10:39 am
Contact:

Re: NAD+ deficiency?

Unread post by cdraham »

alteredhomeostasis wrote: Mon May 25, 2020 11:21 am There’s like at least 10 essential cellular processes that use these and if anything went wrong with them u would probably die.
So you think NAD+ is ok in us?
Post Reply

Who is online

Users browsing this forum: No registered users and 5 guests