AnhedonicApe - Intro

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Meso
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Re: AnhedonicApe - Intro

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DrugsAreBad wrote: @Mesolimbo: Any idea for how long the regimen should be kept up? And why, so far, positive effects have not been permanent?
You need to look into potentiating long-term potentiation (LTP) more. Your next step should be to restore HPA axis reactivity by downregulating GR. Licorice or a corticosteroid would do that, in theory.
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DrugsAreBad
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Re: AnhedonicApe - Intro

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Mesolimbo wrote:
DrugsAreBad wrote: @Mesolimbo: Any idea for how long the regimen should be kept up? And why, so far, positive effects have not been permanent?
You need to look into potentiating long-term potentiation (LTP) more. Your next step should be to restore HPA axis reactivity by downregulating GR. Licorice or a corticosteroid would do that, in theory.
Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
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Meso
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Re: AnhedonicApe - Intro

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DrugsAreBad wrote: Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
Yes, until you feel potent cortisol effect from the licorice. Then slowly withdraw from it. It has to be slow to prevent rebound upregulation of GR. Also, keep in mind that licorice is a phytoestrogen, so don't dose high.
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Re: AnhedonicApe - Intro

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Mesolimbo wrote:
DrugsAreBad wrote: Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
Yes, until you feel potent cortisol effect from the licorice. Then slowly withdraw from it. It has to be slow to prevent rebound upregulation of GR. Also, keep in mind that licorice is a phytoestrogen, so don't dose high.
What does a potent cortisol effect feel like? Licorice seems to have a mild anxiolytic effect that lasts a few hours. I don't know if that's the effect or if it's indicative of an appropriate dose.
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Meso
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Re: AnhedonicApe - Intro

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DrugsAreBad wrote:
Mesolimbo wrote:
DrugsAreBad wrote: Psilocybin combined with licorice then. Let's say psilocybin every 3 days at barely perceptible doses and a teaspoon of licorice root power a day for a few weeks. Sounds reasonable?
Yes, until you feel potent cortisol effect from the licorice. Then slowly withdraw from it. It has to be slow to prevent rebound upregulation of GR. Also, keep in mind that licorice is a phytoestrogen, so don't dose high.
What does a potent cortisol effect feel like? Licorice seems to have a mild anxiolytic effect that lasts a few hours. I don't know if that's the effect or if it's indicative of an appropriate dose.
An energy boost with either hypomania or mild depression. Increased aggression or irritability.
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Meso
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Re: AnhedonicApe - Intro

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@AnhedonicApe Have you tried Saint John's Wort before?
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AnhedonicApe
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Re: AnhedonicApe - Intro

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Mesolimbo wrote:@AnhedonicApe Have you tried Saint John's Wort before?

Not yet, was a little scared to try. I will start the sarcosine first, after that probably the baclofen to test the 5ht theory.
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Meso
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Re: AnhedonicApe - Intro

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AnhedonicApe wrote:
Mesolimbo wrote:@AnhedonicApe Have you tried Saint John's Wort before?

Not yet, was a little scared to try. I will start the sarcosine first, after that probably the baclofen to test the 5ht theory.
Keep in mind that SJW raises both GABA and glutamate, albeit mildly. Maybe it would be helpful as a last-stand option.
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AnhedonicApe
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Re: AnhedonicApe - Intro

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Mesolimbo wrote:
AnhedonicApe wrote:
Mesolimbo wrote:@AnhedonicApe Have you tried Saint John's Wort before?

Not yet, was a little scared to try. I will start the sarcosine first, after that probably the baclofen to test the 5ht theory.
Keep in mind that SJW raises both GABA and glutamate, albeit mildly. Maybe it would be helpful as a last-stand option.
allright i will remember
umapinha
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Re: AnhedonicApe - Intro

Unread post by umapinha »

@Mesolimbo, can you help me too?
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