PSSD ?

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arahant
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Re: PSSD ?

Unread post by arahant »

Vercingétorix wrote: Tue Dec 01, 2020 6:49 am
arahant wrote: Tue Dec 01, 2020 12:08 am
Buspirone is pre-synaptic in lower doses and post-synaptic like Flibanserin in higher doses...I think that gives you a clue.
I reduced from 60 to 30 mg/day and most of its benefits have "faded away", but they were much more intense than I had prior Sertraline. You can still hunt for a dose that works for you.
Yes, it is my plan to reach at least 30 mg. At witch dose did you start to have benefits ?

arahant wrote: Tue Dec 01, 2020 12:08 am If you have no arousal/ejaculatory problem, just an ED issue, if it comes from GAD, buspirone might help, and yes, anxiety disorders are associated with ED, and it was even a criterion for GAD diagnosis in the past.
Before those last years, I had never had any erection problem, even in the periods I had big anxiety or big depresssion, so I think it doesn't come from anxiety.
ED started when I abruptely lowered citalopram.

arahant wrote: Tue Dec 01, 2020 12:08 am But if it's not. There are other options like Viagra/Cialis/L-Citruline.
I take viagra/cialis but it doesn't work so well.
I'll give another try to citruline and arginine.
40-60 mg was the range that worked best, I think I have posted it on my thread like an year ago... I tapered because of sides (dizziness), and I was having food cravings like the ones people experience the hour after using weed.

Are you still on citalopram?
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Vercingétorix
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Re: PSSD ?

Unread post by Vercingétorix »

arahant wrote: Tue Dec 01, 2020 8:32 am
40-60 mg was the range that worked best, I think I have posted it on my thread like an year ago... I tapered because of sides (dizziness), and I was having food cravings like the ones people experience the hour after using weed.

Are you still on citalopram?
Yes I am still on citalopram, I 'm just finishing a very slow taper from 40 mg to 20 mg. It took 7 month.

You are currently at 30 mg of buspirone, and your pssd symptoms have not come back, right ?
BurgerMile
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Re: PSSD ?

Unread post by BurgerMile »

Vercingétorix wrote: Tue Dec 01, 2020 6:59 am
BurgerMile wrote: Tue Dec 01, 2020 1:33 am That's really interesting, arahant.

Too bad Buspirone was discontinued in my country eight years ago.
You cannot buy it online ?
Probably, but I doubt it. The websites I found that sell it look very sketchy, to say the least.
arahant
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Re: PSSD ?

Unread post by arahant »

Vercingétorix wrote: Tue Dec 01, 2020 9:53 am
arahant wrote: Tue Dec 01, 2020 8:32 am
40-60 mg was the range that worked best, I think I have posted it on my thread like an year ago... I tapered because of sides (dizziness), and I was having food cravings like the ones people experience the hour after using weed.

Are you still on citalopram?
Yes I am still on citalopram, I 'm just finishing a very slow taper from 40 mg to 20 mg. It took 7 month.

You are currently at 30 mg of buspirone, and your pssd symptoms have not come back, right ?
Not like without taking it, but 30 mg is not like 40 - 60 mg...but have to be cautious not to lose my reference, the response I got on the maximum dose range was better than even before taking sertraline, and putting that as the "new baseline" might not be a wise assumption. Because it's a response to a drug. I am still searching for anything close to a "natural" response that I don't feel dependent on a drug.
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Vercingétorix
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Re: PSSD ?

Unread post by Vercingétorix »

I will be soon reaching 30 mg of buspirone and still don't have any sign of improvement, so if it still doesn't work in a few months I'll have to find another thing. I plan to give a try to SJW, as some people had a good improvement on it, and make other mucuna cures.

If those natural products don't work on me I think I would be tempted to try bupropion, but the problem is in my country this medicine is not covered by social security. I could afford myself a 150 mg cure, but 300 mg would be too expansive. So I have a question for those who have experience or anowledge on this medicine : can it improve sexual function at 150 mg ? I have read some studies that conclude it can, and others that the dose must be 300, so I don't know which one I should believe.
arahant
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Re: PSSD ?

Unread post by arahant »

Vercingétorix wrote: Wed Dec 16, 2020 1:05 pm I will be soon reaching 30 mg of buspirone and still don't have any sign of improvement, so if it still doesn't work in a few months I'll have to find another thing.
The meaning of "improvement" can vary a lot from person to person.
Better adjust your expectations, for example, waiting for a viagra-like result from a drug that does not work like that.
Are you still taking SSRI?
The dose for people taking SSRI + buspirone was way higher than 30 mg/day as far as I know.
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Re: PSSD ?

Unread post by Vercingétorix »

arahant wrote: Wed Dec 16, 2020 1:43 pm
Vercingétorix wrote: Wed Dec 16, 2020 1:05 pm I will be soon reaching 30 mg of buspirone and still don't have any sign of improvement, so if it still doesn't work in a few months I'll have to find another thing.
The meaning of "improvement" can vary a lot from person to person.
Better adjust your expectations, for example, waiting for a viagra-like result from a drug that does not work like that.
Are you still taking SSRI?
The dose for people taking SSRI + buspirone was way higher than 30 mg/day as far as I know.

I meant no improvement on my erections, because it is my remaining problem. In fact I don't feel any change with buspirone, I am not less anxious and I don't have a better mood. I have more dreams, that's all. Maybe more libido too, but I am not sure it comes from buspirone, it could be just a natural fluctuation. Maybe this medicine doesn't work for me.

Yes I am still on citalopram, 20 mg currently, but I plan to make a new taper off to 0, because I think this drug doesn't help me any more for the mood. It will take months. And who knows, maybe my sexual function could be better when my body is citalopram-free.

So the dose of buspirone should be more than 30 mg ? I am a little tired of cutting my pills and wait for an hypothetical improvement, it is very long, but maybe I 'm gonna go up to 40 mg. I'll have to convince my doctor to increase the dose.
arahant
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Re: PSSD ?

Unread post by arahant »

Vercingétorix wrote: Wed Dec 16, 2020 3:03 pm
arahant wrote: Wed Dec 16, 2020 1:43 pm
Vercingétorix wrote: Wed Dec 16, 2020 1:05 pm I will be soon reaching 30 mg of buspirone and still don't have any sign of improvement, so if it still doesn't work in a few months I'll have to find another thing.
The meaning of "improvement" can vary a lot from person to person.
Better adjust your expectations, for example, waiting for a viagra-like result from a drug that does not work like that.
Are you still taking SSRI?
The dose for people taking SSRI + buspirone was way higher than 30 mg/day as far as I know.

I meant no improvement on my erections, because it is my remaining problem. In fact I don't feel any change with buspirone, I am not less anxious and I don't have a better mood. I have more dreams, that's all. Maybe more libido too, but I am not sure it comes from buspirone, it could be just a natural fluctuation. Maybe this medicine doesn't work for me.

Yes I am still on citalopram, 20 mg currently, but I plan to make a new taper off to 0, because I think this drug doesn't help me any more for the mood. It will take months. And who knows, maybe my sexual function could be better when my body is citalopram-free.

So the dose of buspirone should be more than 30 mg ? I am a little tired of cutting my pills and wait for an hypothetical improvement, it is very long, but maybe I 'm gonna go up to 40 mg. I'll have to convince my doctor to increase the dose.
If you are still taking SSRis, it can be just sexual side effects, which are known for decades.

Better not bothering much about having PSSD for obvious reasons.

For erection fanatics, I guess everyone agrees that Viagra or Cialis is the best available.

But wait,

Aren't you the guy who functioned better on high doses of citalopram? Why are you tapering it?

Discuss with your doctor if depression is playing a role.

Buspirone augmentation improved cognitive symptoms in this study.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449841/

Previous studies have suggested that doses of buspirone above 40 mg had antidepressant effects in MDD:

Robinson et al., 1990: https://europepmc.org/article/med/2198303
Rickels et al., 1991: https://psycnet.apa.org/record/1991-19576-001

Best of luck
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
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Vercingétorix
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Re: PSSD ?

Unread post by Vercingétorix »

arahant wrote: Wed Dec 16, 2020 4:34 pm
But wait,

Aren't you the guy who functioned better on high doses of citalopram? Why are you tapering it?

Discuss with your doctor if depression is playing a role.

Buspirone augmentation improved cognitive symptoms in this study.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449841/

Previous studies have suggested that doses of buspirone above 40 mg had antidepressant effects in MDD:

Robinson et al., 1990: https://europepmc.org/article/med/2198303
Rickels et al., 1991: https://psycnet.apa.org/record/1991-19576-001

Best of luck
Yes I am the guy who functionned better on high doses of citalopram. I used to. I had ED after lowering abruptely, and when I went back to a high dose the ED was improved only temporarily, 2 or 3 months. So now I am back to a low dose, and I want to taper off because I think this medicine doesn't help me any more, sexually and for depression.


Hypersexuality on ssri is rare, but it exists :

https://www.ncbi.nlm.nih.gov/pmc/articl ... 0treatment.
Although the mechanism of SSRI-induced hypersexuality is still speculative, SSRIs have been associated with hypersexuality both independently and in combination with bupropion. Clinicians should be aware of hypersexuality as a rare but distressing side effect of SSRI treatment.
arahant
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Re: PSSD ?

Unread post by arahant »

Interesting, but it says hypersexuality and combined with buproprion. Also considered distressing. I know a plenty who would sell their kidneys to get sexual life back.

The weird thing that I took the exact combo of Sertraline and buproprion like the link you posted, and here I am talking buspirone since Feb 2019.

If it's just Ed, no worries about having PSSD because you are still taking your SSRI. I think you can find a balance discussing a better regimen with your doctor.
Wellbutrin (2007 - 2018)
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Wellbutrin + Ritalin (2016 - 2018)
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