PSSD ?

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Vercingétorix
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Re: PSSD ?

Unread post by Vercingétorix »

arahant wrote: Interesting, but it says hypersexuality and combined with buproprion. Also considered distressing. I know a plenty who would sell their kidneys to get sexual life back.
The case studied here is a man who is on sertraline+bupropion, but the article says also hypersexuality car occur with an ssri alone. I guess it may be distressing if the sexual drive is extremely high.

arahant wrote: The weird thing that I took the exact combo of Sertraline and buproprion like the link you posted, and here I am talking buspirone since Feb 2019.
It didn't work on you, so you tried another medicine. That's not weird.

arahant wrote: If it's just Ed, no worries about having PSSD because you are still taking your SSRI. I think you can find a balance discussing a better regimen with your doctor.
What do you mean by balance ?
arahant
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Re: PSSD ?

Unread post by arahant »

Vercingétorix wrote: Thu Dec 17, 2020 12:02 pm
arahant wrote: Interesting, but it says hypersexuality and combined with buproprion. Also considered distressing. I know a plenty who would sell their kidneys to get sexual life back.
The case studied here is a man who is on sertraline+bupropion, but the article says also hypersexuality car occur with an ssri alone. I guess it may be distressing if the sexual drive is extremely high.
arahant wrote: The weird thing that I took the exact combo of Sertraline and buproprion like the link you posted, and here I am talking buspirone since Feb 2019.
It didn't work on you, so you tried another medicine. That's not weird.

arahant wrote: If it's just Ed, no worries about having PSSD because you are still taking your SSRI. I think you can find a balance discussing a better regimen with your doctor.
What do you mean by balance ?
I was hypersexual before, Sertraline + Buproprion basically destroyed it.

It's a matter of perspective, maybe the man on the study had near-zero sexual life, then this combo may put him functioning.

Balance -> finding a regimen that works for you.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
Vercingétorix
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Re: PSSD ?

Unread post by Vercingétorix »

A quick update :

After 5 month on buspirone I decided to start a slow decrease because there was no improvement at all. I went until 30 mg.

The good new is that this month I had very good results with yohimbe, I took it about 3 times a week at high dose (15 mg yohimbine if the percentage on the bottle is right), and it worked very well for 3 weeks. I could be very horny watching porn, and my erection was strong like in the good old days. The side effects were not so bad, the main one is a rapid heart rate, and i had also tremors when I was cold (I must be careful when I take yohimbe in the winter).
It seems that I started building a tolerance after these 3 weeks, it doesn't work well, so I will wait for one month before taking it again. It's a better treatement than cialis/viagra for me, especially now I can handle a high dose. When I tried it the first times I could not take more than 5 mg at a time, and the improvement was not so big. One strange thing about yohimbe is the delayed action : the effects come 2 hours after I took the pills. Not very practical, but manageable. From what I've read, it can be very different for one person to another, some people got the effects after only 45 minutes.

My plan for february : try cordyceps.
arahant
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Re: PSSD ?

Unread post by arahant »

Have you taken your SSRI+buspirone+yohimbine at high doses during this period?
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
Vercingétorix
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Re: PSSD ?

Unread post by Vercingétorix »

Do you really think buspirone can help every man on this forum ?
arahant
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Re: PSSD ?

Unread post by arahant »

Vercingétorix wrote: Sun Jan 24, 2021 10:29 am Do you really think buspirone can help every man on this forum ?
I am just asking details of your last regimen, I have considered yohimbine in the past but I skipped it. You said something interesting about its results. And if you are still taking an SSRI, I really don't know why you are here. It sounds misleading for the majority of people who come here without taking any SSRIs and still experiencing it's side effects. Go back to your high dose SSRi regimen with no sexual sides and be happy.
Last edited by arahant on Sun Jan 24, 2021 11:12 am, edited 4 times in total.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
Thomas
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Joined: Thu Jul 09, 2020 6:32 am
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Re: PSSD ?

Unread post by Thomas »

Vercingétorix wrote: Sun Jan 24, 2021 10:29 am Do you really think buspirone can help every man on this forum ?
Let's split people on this forum in two groups:
1) Those who are still taking SSRIs. In this case there are lots of scientific studies and buspirone is one of the few drugs (yohimbine too) with a proven efficiency against SD while on SSRIs. I undestand you are in this group, for which buspirone would be one of the common thing to try. You did.
2) Those with SD without taking anything (PSSD). In this case there is almost no study and no clear solution.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
arahant
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Re: PSSD ?

Unread post by arahant »

Thomas wrote: Sun Jan 24, 2021 11:07 am 1) Those who are still taking SSRIs. In this case there are lots of scientific studies and buspirone is one of the few drugs (yohimbine too) with a proven efficiency against SD while on SSRIs.
That's one reason I put yohimbine on hold, because it would be like taking two 5HT1a agonists at the same time. The other was its pharmacokinetics, acute absorption and fast elimination (about 30 min half life), but it can be something also positive if someone consider taking yohimbine "as needed" just before sex. But,
Yohimbine is still on my "alternatives radar"
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
Vercingétorix
Posts: 106
Joined: Tue Apr 14, 2020 4:23 am
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Re: PSSD ?

Unread post by Vercingétorix »

Thomas wrote: Sun Jan 24, 2021 11:07 am
Vercingétorix wrote: Sun Jan 24, 2021 10:29 am Do you really think buspirone can help every man on this forum ?
Let's split people on this forum in two groups:
1) Those who are still taking SSRIs. In this case there are lots of scientific studies and buspirone is one of the few drugs (yohimbine too) with a proven efficiency against SD while on SSRIs. I undestand you are in this group, for which buspirone would be one of the common thing to try. You did.
2) Those with SD without taking anything (PSSD). In this case there is almost no study and no clear solution.
Things are not always so simple. In my case, ED and genital anesthesia appeared after I lowered the ssri. If it were just common side effects, it should have occured when I was on the highest dose, and then improved when I decreased the dose, right ?
Obviously after a while I asked my doctor to go back to a higher dose, the result was an immediate improvement in sexual function, but only temporary for the ED, that still remains today.

arahant wrote: Sun Jan 24, 2021 11:05 am
Vercingétorix wrote: Sun Jan 24, 2021 10:29 am Do you really think buspirone can help every man on this forum ?
And if you are still taking an SSRI, I really don't know why you are here. It sounds misleading for the majority of people who come here without taking any SSRIs and still experiencing it's side effects.

Well, the products I 've tried (inositol, maca, buspirone, yohimbe,...) are the same as most of men who suffer of pssd, so I don't think it can mislead anyone here. Every case is different, a product that works very well on someone can lead another to a crash, so I don't think I can mislead someone more than you or other people here. And the most of my messages are in this thread, so it's easy for a reader to find my story if he wants to know my case.
Thomas
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Re: PSSD ?

Unread post by Thomas »

Vercingétorix wrote: Sun Jan 24, 2021 1:02 pm Things are not always so simple. In my case, ED and genital anesthesia appeared after I lowered the ssri. If it were just common side effects, it should have occured when I was on the highest dose, and then improved when I decreased the dose, right ?
Obviously after a while I asked my doctor to go back to a higher dose, the result was an immediate improvement in sexual function, but only temporary for the ED, that still remains today.
You might suffer from PSSD the day you stop SSRIs. But you won't know for sure if your SD is (rare) PSSD or (common) side effects until you stop SSRIs. One way to be sure without risking depression would we switching from SSRIs to another class of antidepressants. You could speak with your doc about this.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
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