Transcriptional dysregulation of 5-HT1A autoreceptors

[iull1k]

https://molecularbrain.biomedcentral.co ... -6606-4-21

Just check this study carefully.

"Interestingly, 5-HT1A agonists downregulate GR in raphe cells in culture, which would lead to an increase in 5-HT1A autoreceptors [172]."
" Conversely, knockdown of GR abrogates the down-regulation of 5-HT1A autoreceptors induced by chronic mild stress in mice [173]"
" Since glucocorticoids are dys-regulated in depression, the chronic elevation of cortisol may ultimately desensitize GR and could contribute to increase 5-HT1A autoreceptor expression in depression."

This is opposite to what Ghost post here :
http://www.pssdforum.com/viewtopic.php? ... vels#p5203
"With Elevated Glucocorticoid (Cortisol (or hydrocortisone) is the most important human glucocorticoid) levels are elevated (From sleep loss or chronic stress), Glucocorticoid levels appear to repress 5HT ARs. Additionally, Glucocorticoids can uncouple 5HT ARs by reducing GIRK2 RNA levels. This should strike you as very important, because as stated earlier, GIRK2 is used by 5HT1A ARs to hyperpolarize the presynaptic cell, and inhibit 5HT release."

Licorice Root elevates Cortisol, so if this afirmation is correct, that means that chronic licorice root consumption increase 5-HT1A autoreceptor expression. So, cured guy maybe tell us true story? : ) He used licorice root for extended time enough to increase 5-HT1A Autoreceptors?

[iull1k]

https://www.ncbi.nlm.nih.gov/pubmed/22826341

"A functional polymorphism, rs6295 in the Htr1a promoter region, blocks the function of specific repressors Hes1, Hes5 and Deaf1, resulting in increased 5-HT(1A) autoreceptor expression in animal models and humans."

[Ghost]

Yea this is Dr. Albert's work. I think he's from Canada if I remember right. He's the go-to guy for the 5HT1A receptor from the genetic standpoint.

[Tree]

Is there evidence to support over expression of GR induced by ssri?