Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.nasibi wrote:Gut microbiome is BS. The epigentic modifications done by SSRIs is mainly DNA hypermethylation, which in turn attracts HDAC. You are right about SCFA acting as HDAC inhibitors. I have suggested Keto deit (ß-hydroxyButyrate) or Valproate for that purpose in my previous posts.
https://www.ncbi.nlm.nih.gov/pubmed/17012225